Xeris Biopharma (XERS) Drops 9.3% Following XP-8121 Patent Milestone Announcement – Is the Bullish Outlook Still Valid?
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 06 2025
0mins
Source: Yahoo Finance
Patent Milestone: Xeris Biopharma Holdings received a Notice of Allowance from the USPTO for its patent application on XP-8121, a once-weekly, subcutaneous levothyroxine formulation, enhancing its intellectual property protection in the levothyroxine market.
Investment Outlook: The patent approval is seen as a positive long-term catalyst for Xeris, potentially reducing reliance on existing products, but investors should remain cautious about the company's current dependence on its commercial drugs and the risks associated with rising R&D and SG&A costs.
Revenue Projections: Xeris is projected to achieve $440.9 million in revenue and $84.8 million in earnings by 2028, necessitating significant annual growth, while current valuations among analysts vary widely, indicating differing expectations for the company's future performance.
Research and Analysis: Simply Wall St offers a comprehensive analysis of Xeris Biopharma, highlighting key rewards and risks, and emphasizes the importance of evaluating the company's financial health and market position before making investment decisions.
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Analyst Views on XERS
Wall Street analysts forecast XERS stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for XERS is 11.00 USD with a low forecast of 8.00 USD and a high forecast of 18.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
6 Analyst Rating
5 Buy
1 Hold
0 Sell
Strong Buy
Current: 7.240
Low
8.00
Averages
11.00
High
18.00
Current: 7.240
Low
8.00
Averages
11.00
High
18.00
About XERS
Xeris Biopharma Holdings, Inc. is a biopharmaceutical company focused on improving patient lives by developing and commercializing products across a range of therapies. It has three commercially available products: Recorlev, Gvoke, and Keveyis. Recorlev is for the treatment of endogenous Cushing’s syndrome. Gvoke is a ready-to-use liquid glucagon for the treatment of severe hypoglycemia. Keveyis is a therapy for primary periodic paralysis. It also has a pipeline of development programs led by XP-8121, a phase III-ready, once-weekly subcutaneous injection for hypothyroidism. It is pursuing formulation and development partnerships to apply its XeriSol and XeriJect formulation technologies to enhance the drug delivery and clinical profile of other companies’ proprietary drugs and biologics. Recorlev is a cortisol synthesis inhibitor approved for the treatment of endogenous hypercortisolemia in adults with Cushing's syndrome for whom surgery is not an option or has not been curative.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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Xeris Anticipates 2025 Revenue of $292 Million, Exceeding Guidance
- Revenue Growth: Xeris anticipates total revenue of $292 million for 2025, exceeding the guidance range of $285-$290 million and reflecting a 44% increase from the previous year, indicating strong market demand and product performance.
- Product Performance: Recorlev® achieved net revenue of $45 million in Q4 2025 and $139 million for the full year, demonstrating increasing market acceptance in treating endogenous Cushing's syndrome.
- Patient Base Expansion: By the end of 2025, approximately 700 patients were on Recorlev® therapy, while Gvoke® saw revenue growth of over 13% year-over-year, showcasing the company's success in patient treatment and market penetration.
- Financial Stability: Xeris delivered positive adjusted EBITDA in every quarter, reinforcing the company's financial foundation and positioning it for sustained growth in the future.
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