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CRNX Overview

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ET
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Intellectia

Loading chart...

High
36.230
Open
35.780
VWAP
35.52
Vol
1.93M
Mkt Cap
3.75B
Low
34.790
Amount
68.60M
EV/EBITDA(TTM)
--
Total Shares
105.44M
EV
2.51B
EV/OCF(TTM)
--
P/S(TTM)
192.92
Crinetics Pharmaceuticals, Inc. is a clinical-stage pharmaceutical company focused on the discovery, development and commercialization of therapeutics for rare endocrine diseases and endocrine-related tumors. Its lead development candidate, PALSONIFY (paltusotine), is the first investigational once-daily, oral, selective somatostatin receptor type 2 (SST2) nonpeptide agonist that is in clinical development for acromegaly and carcinoid syndrome associated with neuroendocrine tumors. Its second product candidate is Atumelnant, which is in clinical development for congenital adrenal hyperplasia (CAH) and patients with either Cushing's disease or Ectopic ACTH Syndrome (EAS). Its drug candidates are orally delivered, small molecule new chemical entities resulting from in-house drug discovery efforts, including other programs addressing a variety of endocrine conditions such as hyperparathyroidism, polycystic kidney disease, Graves' disease, thyroid eye disease, diabetes and obesity.
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Events Timeline

(ET)
2026-05-07
17:30:00
Crinetics Q1 Revenue $10.73M, Beats Expectations
select
2026-04-27 (ET)
2026-04-27
17:20:00
Crinetics Receives EU Approval for Palsonify in Adult Acromegaly
select
2026-04-13 (ET)
2026-04-13
09:00:00
ALX Oncology Appoints Jeff Knight as Chief Development and Operating Officer
select
2026-03-26 (ET)
2026-03-26
16:40:00
Crinetics Submits Marketing Authorization Application for Palsonify in Brazil
select

News

Fool
8.5
05-18Fool
ADAR1 Capital Increases Stake in Crinetics Pharmaceuticals
  • Share Increase: ADAR1 Capital Management disclosed a purchase of 829,963 shares of Crinetics Pharmaceuticals in Q1 2026, with an estimated trade value of $37.07 million, indicating strong confidence in the company.
  • Stake Growth: Following this acquisition, ADAR1's stake in Crinetics now stands at 2.44%, highlighting its significance within the fund's asset management strategy.
  • Financial Performance: The quarter-end value of Crinetics increased by $26.98 million due to both the share addition and price changes, despite the company facing a quarterly cash burn of approximately $150 million for R&D and commercialization.
  • Market Outlook: Crinetics recently launched its first commercial drug, Palsonify, and while Q1 revenue exceeded expectations, the stock price still fell, reflecting market concerns regarding its future profitability.
seekingalpha
9.5
05-08seekingalpha
Crinetics Pharmaceuticals Q1 2026 Earnings Call Highlights
  • Patient Enrollment Surge: Crinetics reported 232 new patient enrollments in Q1 2026, driving net product revenue to $10.3 million, indicating increasing market acceptance of Palsonify, which is on track to become the preferred treatment for acromegaly.
  • International Regulatory Progress: The company received MAA approval from the European Commission and submitted applications in Japan and Brazil, demonstrating a strategic push for international market expansion that is expected to lay the groundwork for future revenue growth.
  • Reimbursement Coverage Improvement: Approximately 70% of patients were reimbursed by the end of Q1, with a goal to exceed 75% coverage by Q3 2026, which will enhance market competitiveness and increase patient adoption.
  • Stable Financial Outlook: Despite R&D expenses reaching $100.1 million in Q1, the company projects that its existing cash and investments will fund operations into 2030, reflecting financial health and ongoing investment capability.
Yahoo Finance
8.5
05-02Yahoo Finance
Crinetics Pharmaceuticals: Stock Potential Analysis
  • Investment Return Potential: Crinetics Pharmaceuticals (NASDAQ:CRNX) first appeared in Farallon Capital's 13F portfolio in Q3 2018 with over 141,000 shares, indicating early confidence in the investment.
  • Holding Dynamics: By early 2019, the fund completely sold off its stake, but reopened a position in Q3 2023, with the latest disclosure showing nearly 500,000 shares in Q2 2024, reflecting sustained interest in the company.
  • Optimistic Market Outlook: Crinetics' PALSONIFY received European Commission approval, becoming the only once-daily oral treatment on the market, with projected revenues of $62 million in 2026, significantly exceeding original consensus estimates, indicating rapid market acceptance of its product.
  • Increased Hedge Fund Confidence: Early data shows a 5% adoption rate for PALSONIFY within months of launch, suggesting that hedge funds are optimistic about Crinetics' future growth, which could drive stock price increases.
NASDAQ.COM
8.5
04-30NASDAQ.COM
Latest Developments in the Biotech Sector
  • Regulatory Approvals: Crinetics received European Commission approval for PALSONIFY to treat acromegaly in adults, becoming the first once-daily oral therapy in Europe, covering 27 EU member states, which is expected to significantly enhance market share.
  • Acquisition Expansion: Teva is acquiring Emalex Biosciences for $700 million, bolstering its neuroscience pipeline and potentially accelerating the NDA submission for Ecopipam, thereby strengthening Teva's competitive position in the CNS disorders market.
  • Clinical Trial Progress: Biomea Fusion's Icovamenib showed a 52% increase in mean C-peptide AUC in its Phase 2 trial for Type 1 Diabetes, indicating potential efficacy in early-stage patients, which may drive further development efforts.
  • Market Reactions: Despite multiple approvals, AstraZeneca and Novartis saw their stock prices decline by 0.79% and 1.76% respectively, reflecting a cautious investor sentiment towards the biotech sector.
NASDAQ.COM
8.5
04-28NASDAQ.COM
Crinetics' PALSONIFY Receives EU Approval for Acromegaly Treatment
  • Drug Approval: Crinetics Pharmaceuticals announced that its oral drug PALSONIFY (Paltusotine) has received approval from the European Commission for the treatment of adult patients with acromegaly, marking its legal launch across 27 EU member states and 3 EEA countries.
  • Clinical Trial Results: The approval of PALSONIFY is based on data from two pivotal Phase 3 trials, PATHFNDR-1 and PATHFNDR-2, which demonstrated rapid onset, reliable biochemical control, and sustained efficacy in both medically untreated and previously treated patients.
  • Market Potential: Following FDA approval in Q4 2025, PALSONIFY generated net product revenue of $5.4 million, indicating strong market potential, while Crinetics reported cash and investment securities totaling $1.0 billion, providing ample funding for future R&D.
  • Stock Performance: CRNX shares have traded between $25.83 and $57.99 over the past year, closing at $38.62 on Monday with a 0.76% increase, although down 1.61% to $38.00 in after-hours trading, reflecting a positive market response to the new drug approval.
Newsfilter
8.5
04-27Newsfilter
PALSONIFY Approved in EU for Acromegaly Treatment
  • First Approval: Crinetics' PALSONIFY becomes the first once-daily oral therapy approved in the EU for acromegaly, marking a significant step in establishing the company's leadership in the global endocrinology sector.
  • Clinical Data Support: The approval is based on pivotal Phase 3 trials, PATHFNDR-1 and PATHFNDR-2, demonstrating significant biochemical control and symptom relief, enhancing its competitive edge in the market.
  • Market Launch Plans: Crinetics plans initial commercialization efforts in Germany and Austria, which are expected to rapidly address the treatment needs for acromegaly in these regions, thereby increasing the company's influence in the European market.
  • International Collaboration: Crinetics is partnering with Japan's Sanwa Kagaku Kenkyusho to develop PALSONIFY, having applied for orphan drug designation in Japan, reflecting its strategic intent for global expansion.
Wall Street analysts forecast CRNX stock price to rise
11 Analyst Rating
Wall Street analysts forecast CRNX stock price to rise
11 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
67.00
Averages
89.40
High
105.00
Current: 0.000
sliders
Low
67.00
Averages
89.40
High
105.00
Evercore ISI
Gavin Clark-Gartner
Outperform
to
Outperform
downgrade
$89 -> $88
AI Analysis
2026-05-15
Reason
Evercore ISI
Gavin Clark-Gartner
Price Target
$89 -> $88
AI Analysis
2026-05-15
downgrade
Outperform
to
Outperform
Reason
Evercore ISI analyst Gavin Clark-Gartner lowered the firm's price target on Crinetics to $88 from $89 and keeps an Outperform rating on the shares.
Oppenheimer
Oppenheimer
Outperform
to
Outperform
downgrade
$87 -> $84
2026-05-11
Reason
Oppenheimer
Oppenheimer
Price Target
$87 -> $84
2026-05-11
downgrade
Outperform
to
Outperform
Reason
Oppenheimer lowered the firm's price target on Crinetics to $84 from $87 and keeps an Outperform rating on the shares following quarterly results. Phase 3 trial in carcinoid syndrome continues its enrollment, and atumelnant is moving along in its respective pivotal and Phase 2 trials in adult and pediatric CAH with a Phase 2/3 to soon begin in ACTH-dependent Cushing syndrome. Oppenheimer has its eye on CRN09682's initial clinical reveal in neuroendocrine tumors, which the firm believes will come toward year-end. Current levels may reflect a relative paucity of upcoming catalysts, but Oppenheimer thinks today's buyers will be rewarded as Crinetics' growing endocrine portfolio marks commercial and clinical success.
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Valuation Metrics

The current forward P/E ratio for Crinetics Pharmaceuticals Inc (CRNX.O) is 0.00, compared to its 5-year average forward P/E of -8.31. For a more detailed relative valuation and DCF analysis to assess Crinetics Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-8.31
Current PE
0.00
Overvalued PE
-5.43
Undervalued PE
-11.19

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-5.28
Current EV/EBITDA
-1.65
Overvalued EV/EBITDA
-2.08
Undervalued EV/EBITDA
-8.48

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
942.88
Current PS
21.95
Overvalued PS
2194.10
Undervalued PS
-308.34

Financials

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Whales Holding CRNX

N
Novo Holdings A/S
Holding
CRNX
+20.39%
3M Return
D
Driehaus Capital Management LLC
Holding
CRNX
+14.26%
3M Return
F
Farallon Capital Management, L.L.C.
Holding
CRNX
+11.81%
3M Return
A
Artal Group S.A.
Holding
CRNX
+11.24%
3M Return
P
Paradigm Biocapital Advisors LP
Holding
CRNX
+8.52%
3M Return
G
GW&K Investment Management, LLC
Holding
CRNX
+8.00%
3M Return

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Frequently Asked Questions

What is Crinetics Pharmaceuticals Inc (CRNX) stock price today?

The current price of CRNX is 35.55 USD — it has decreased -1.28

What is Crinetics Pharmaceuticals Inc (CRNX)'s business?

Crinetics Pharmaceuticals, Inc. is a clinical-stage pharmaceutical company focused on the discovery, development and commercialization of therapeutics for rare endocrine diseases and endocrine-related tumors. Its lead development candidate, PALSONIFY (paltusotine), is the first investigational once-daily, oral, selective somatostatin receptor type 2 (SST2) nonpeptide agonist that is in clinical development for acromegaly and carcinoid syndrome associated with neuroendocrine tumors. Its second product candidate is Atumelnant, which is in clinical development for congenital adrenal hyperplasia (CAH) and patients with either Cushing's disease or Ectopic ACTH Syndrome (EAS). Its drug candidates are orally delivered, small molecule new chemical entities resulting from in-house drug discovery efforts, including other programs addressing a variety of endocrine conditions such as hyperparathyroidism, polycystic kidney disease, Graves' disease, thyroid eye disease, diabetes and obesity.

What is the price predicton of CRNX Stock?

Wall Street analysts forecast CRNX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for CRNX is89.40 USD with a low forecast of 67.00 USD and a high forecast of 105.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Crinetics Pharmaceuticals Inc (CRNX)'s revenue for the last quarter?

Crinetics Pharmaceuticals Inc revenue for the last quarter amounts to 10.73M USD, increased 2873.41

What is Crinetics Pharmaceuticals Inc (CRNX)'s earnings per share (EPS) for the last quarter?

Crinetics Pharmaceuticals Inc. EPS for the last quarter amounts to -1.23 USD, increased 18.27

How many employees does Crinetics Pharmaceuticals Inc (CRNX). have?

Crinetics Pharmaceuticals Inc (CRNX) has 594 emplpoyees as of May 31 2026.

What is Crinetics Pharmaceuticals Inc (CRNX) market cap?

Today CRNX has the market capitalization of 3.75B USD.