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CRNX Overview

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Intellectia

Loading chart...

High
36.010
Open
35.820
VWAP
35.57
Vol
1.32M
Mkt Cap
3.72B
Low
35.130
Amount
46.81M
EV/EBITDA(TTM)
--
Total Shares
104.71M
EV
2.70B
EV/OCF(TTM)
--
P/S(TTM)
434.71
Crinetics Pharmaceuticals, Inc. is a clinical-stage pharmaceutical company focused on the discovery, development and commercialization of therapeutics for rare endocrine diseases and endocrine-related tumors. Its lead development candidate, PALSONIFY (paltusotine), is the first investigational once-daily, oral, selective somatostatin receptor type 2 (SST2) nonpeptide agonist that is in clinical development for acromegaly and carcinoid syndrome associated with neuroendocrine tumors. Its second product candidate is Atumelnant, which is in clinical development for congenital adrenal hyperplasia (CAH) and patients with either Cushing's disease or Ectopic ACTH Syndrome (EAS). Its drug candidates are orally delivered, small molecule new chemical entities resulting from in-house drug discovery efforts, including other programs addressing a variety of endocrine conditions such as hyperparathyroidism, polycystic kidney disease, Graves' disease, thyroid eye disease, diabetes and obesity.
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Events Timeline

(ET)
2026-02-26
17:10:00
Crinetics Reports Q4 Revenue of $6.16M, Exceeding Expectations
select
2026-01-22 (ET)
2026-01-22
16:30:00
Crinetics Doses First Patient in BALANCE-CAH Trial
select
2026-01-07 (ET)
2026-01-07
12:10:00
Crinetics Stock Rises 14.7% to $52.70
select
2026-01-07
12:00:00
Major Averages Mixed Ahead of Key Economic Data Release
select

News

seekingalpha
9.5
02-27seekingalpha
Crinetics Pharmaceuticals Q4 2025 Earnings Call Highlights
  • Successful Product Launch: Crinetics' first commercial product, PALSONIFY, was successfully launched, with CEO Struthers noting over 200 enrollment forms received in Q4, indicating strong market demand and positioning the drug as the preferred treatment for acromegaly, thereby solidifying the company's market position in endocrinology.
  • Strong Financial Performance: In Q4 2025, Crinetics reported total net revenue of $6.2 million, with $5.4 million from PALSONIFY's U.S. commercial sales and $0.8 million from a licensing agreement with a Japanese partner, showcasing a solid start in its commercialization efforts.
  • Ongoing R&D Investment: Although R&D expenses for 2025 were $85.1 million, down from $90.5 million in Q3, the company plans to increase operating expenses in 2026 to support new clinical trials and PALSONIFY's commercialization, reflecting confidence in future growth.
  • Healthy Cash Flow Position: By the end of 2025, Crinetics had over $1 billion in cash and cash equivalents, and with the January 2026 public offering, total funds are expected to reach approximately $1.4 billion, ensuring sufficient capital to fund operations into 2030 and supporting long-term growth potential.
NASDAQ.COM
8.5
01-29NASDAQ.COM
Analyst Target Prices Indicate Potential for Pharmaceuticals ETF
  • ETF Upside Potential: The iShares U.S. Pharmaceuticals ETF (IHE) has an implied analyst target price of $96.28 per unit, while trading at $86.15, indicating an 11.76% upside, reflecting market optimism about the ETF's future performance.
  • MBX Stock Analysis: MBX BIOSCIENCES INC (MBX) trades at $35.83, with an analyst target price of $60.55, suggesting a potential upside of 69.01%, showcasing investor confidence in its future prospects.
  • CRNX Stock Outlook: Crinetics Pharmaceuticals Inc (CRNX) has a current price of $51.32 and an analyst target of $83.46, indicating a 62.63% upside, reflecting positive market sentiment regarding its product and R&D advancements.
  • XERS Investment Opportunity: Xeris Biopharma Holdings Inc (XERS) is priced at $7.14, with an analyst target of $11.14, showing a 56.05% upside, indicating analysts' optimism about its growth potential.
Globenewswire
8.5
01-07Globenewswire
Crinetics Prices 7.62M Share Offering at $45.95, Raising $350M
  • Offering Size: Crinetics Pharmaceuticals announced the pricing of 7.62 million shares at $45.95 each, expected to raise approximately $350 million, enhancing the company's financial capacity for future growth initiatives.
  • Use of Proceeds: The proceeds will fund commercial activities related to PALSONIFY™, research and development of new product candidates, and other general corporate purposes, ensuring ongoing innovation in endocrine disease treatment.
  • Underwriter Lineup: The offering is managed by Leerink Partners, J.P. Morgan, Evercore ISI, Piper Sandler, and Cantor, reflecting strong market confidence and support for Crinetics.
  • Market Outlook: With its lead product PALSONIFY™ approved by the FDA, Crinetics is positioned to drive growth in the endocrine tumor treatment market, further solidifying its industry standing.
Benzinga
9.0
01-05Benzinga
Crinetics Pharmaceuticals Reports Significant Results in CAH Study with Atumelnant
  • Rapid Efficacy Demonstrated: In the fourth cohort study, atumelnant resulted in a rapid average reduction of 67% in androstenedione levels among eight patients, indicating significant efficacy in treating congenital adrenal hyperplasia (CAH), which could transform patient treatment protocols.
  • Successful Dose Adjustment: Among patients treated with an 80 mg dose, 88% were able to reduce glucocorticoid doses to physiological replacement levels after 12 weeks, enhancing patient quality of life while potentially reducing long-term side effect risks.
  • Good Safety Profile: Atumelnant showed no serious adverse events during the study, with no participants discontinuing treatment due to adverse events, indicating strong tolerability and enhancing its marketability.
  • Broad Market Potential: Crinetics recognized over $5 million in revenue from Palsonify in Q4 2025, demonstrating strong market acceptance and demand for its products, further solidifying the company's position in the endocrine disease treatment sector.
NASDAQ.COM
9.0
01-05NASDAQ.COM
Crinetics Pharmaceuticals Updates on Atumelnant Phase 2 Trial Results and PALSONIFY Commercialization
  • Clinical Trial Progress: Crinetics Pharmaceuticals announced positive topline results from the Phase 2 trial of Atumelnant for Congenital Adrenal Hyperplasia in January 2025, demonstrating up to an 80% mean reduction in androstenedione levels across three dose cohorts, significantly improving patient health and indicating strong market potential for the drug.
  • New Drug Development: Atumelnant, an oral medication, aims to treat CAH by blocking the MC2R receptor on the adrenal gland, thereby reducing excess cortisol and androgen production, further enhancing Crinetics' innovative capabilities in the endocrine disease sector.
  • Subsequent Trial Initiation: Following the positive Phase 2 results, Crinetics has initiated the Phase 3 CALM-CAH trial to evaluate Atumelnant's ability to normalize adrenal androgen levels while reducing glucocorticoid levels, showcasing the company's ongoing progress in drug development.
  • Market Response: Crinetics' stock rose 0.39% to $46.73 in Friday's trading, reflecting investor optimism regarding the company's drug development advancements and bolstering market confidence in its future growth potential.
Globenewswire
1.0
01-04Globenewswire
Crinetics Pharmaceuticals to Update PALSONIFY™ Commercialization and Phase 2 Trial Results on January 5, 2026
  • Conference Call Announcement: Crinetics Pharmaceuticals will host a conference call on January 5, 2026, at 8:30 a.m. ET to update on PALSONIFY™ (paltusotine) commercialization and disclose topline results from the fourth cohort of the Phase 2 trial, aiming to bolster investor confidence in the company's product pipeline.
  • Product Highlight: PALSONIFY™ is the first once-daily oral treatment approved by the U.S. FDA for adults with acromegaly who have had an inadequate response to surgery, which is expected to enhance the company's market share in the endocrine disease treatment sector.
  • Clinical Development Progress: The ongoing Phase 2 trial of atumelnant for congenital adrenal hyperplasia will provide critical data that could lay the groundwork for future product line expansion, further solidifying Crinetics' leadership in the treatment of endocrine tumors.
  • Investor Engagement: The conference will include a live Q&A session aimed at strengthening communication with investors and enhancing transparency, thereby boosting market confidence in Crinetics' long-term growth potential.
Wall Street analysts forecast CRNX stock price to rise
11 Analyst Rating
Wall Street analysts forecast CRNX stock price to rise
11 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
67.00
Averages
89.40
High
105.00
Current: 0.000
sliders
Low
67.00
Averages
89.40
High
105.00
Citizens
Outperform
to
NULL
downgrade
$105 -> $96
AI Analysis
2026-03-02
Reason
Citizens
Price Target
$105 -> $96
AI Analysis
2026-03-02
downgrade
Outperform
to
NULL
Reason
Citizens lowered the firm's price target on Crinetics to $96 from $105 and keeps an Outperform rating on the shares. Commentary on the Palsonify launch was consistent with management's January preannouncement while the pipeline execution continues at a steady pace, the analyst tells investors in a research note.
Stifel
Alex Thompson
Buy
downgrade
$84 -> $83
2026-02-27
Reason
Stifel
Alex Thompson
Price Target
$84 -> $83
2026-02-27
downgrade
Buy
Reason
Stifel analyst Alex Thompson lowered the firm's price target on Crinetics to $83 from $84 and keeps a Buy rating on the shares.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for CRNX
Unlock Now

Valuation Metrics

The current forward P/E ratio for Crinetics Pharmaceuticals Inc (CRNX.O) is -8.36, compared to its 5-year average forward P/E of -8.23. For a more detailed relative valuation and DCF analysis to assess Crinetics Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-8.23
Current PE
-8.36
Overvalued PE
-5.39
Undervalued PE
-11.08

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-5.64
Current EV/EBITDA
-7.04
Overvalued EV/EBITDA
-2.68
Undervalued EV/EBITDA
-8.60

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
982.03
Current PS
129.59
Overvalued PS
2245.88
Undervalued PS
-281.81

Financials

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Whales Holding CRNX

P
Paradigm Biocapital Advisors LP
Holding
CRNX
+4.86%
3M Return
D
Driehaus Capital Management LLC
Holding
CRNX
+4.55%
3M Return
A
Artal Group S.A.
Holding
CRNX
+4.39%
3M Return
G
GW&K Investment Management, LLC
Holding
CRNX
+2.75%
3M Return
E
EcoR1 Capital, LLC
Holding
CRNX
-2.66%
3M Return
P
Progeny 3, Inc.
Holding
CRNX
-4.37%
3M Return

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Frequently Asked Questions

What is Crinetics Pharmaceuticals Inc (CRNX) stock price today?

The current price of CRNX is 35.57 USD — it has decreased -0.7

What is Crinetics Pharmaceuticals Inc (CRNX)'s business?

Crinetics Pharmaceuticals, Inc. is a clinical-stage pharmaceutical company focused on the discovery, development and commercialization of therapeutics for rare endocrine diseases and endocrine-related tumors. Its lead development candidate, PALSONIFY (paltusotine), is the first investigational once-daily, oral, selective somatostatin receptor type 2 (SST2) nonpeptide agonist that is in clinical development for acromegaly and carcinoid syndrome associated with neuroendocrine tumors. Its second product candidate is Atumelnant, which is in clinical development for congenital adrenal hyperplasia (CAH) and patients with either Cushing's disease or Ectopic ACTH Syndrome (EAS). Its drug candidates are orally delivered, small molecule new chemical entities resulting from in-house drug discovery efforts, including other programs addressing a variety of endocrine conditions such as hyperparathyroidism, polycystic kidney disease, Graves' disease, thyroid eye disease, diabetes and obesity.

What is the price predicton of CRNX Stock?

Wall Street analysts forecast CRNX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for CRNX is89.40 USD with a low forecast of 67.00 USD and a high forecast of 105.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Crinetics Pharmaceuticals Inc (CRNX)'s revenue for the last quarter?

Crinetics Pharmaceuticals Inc revenue for the last quarter amounts to 6.16M USD, decreased

What is Crinetics Pharmaceuticals Inc (CRNX)'s earnings per share (EPS) for the last quarter?

Crinetics Pharmaceuticals Inc. EPS for the last quarter amounts to -1.29 USD, increased 46.59

How many employees does Crinetics Pharmaceuticals Inc (CRNX). have?

Crinetics Pharmaceuticals Inc (CRNX) has 594 emplpoyees as of March 22 2026.

What is Crinetics Pharmaceuticals Inc (CRNX) market cap?

Today CRNX has the market capitalization of 3.72B USD.