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CRNX Overview

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Intellectia

Loading chart...

High
36.790
Open
36.340
VWAP
35.90
Vol
2.01M
Mkt Cap
3.78B
Low
35.050
Amount
72.31M
EV/EBITDA(TTM)
--
Total Shares
105.44M
EV
2.49B
EV/OCF(TTM)
--
P/S(TTM)
192.17
Crinetics Pharmaceuticals, Inc. is a clinical-stage pharmaceutical company focused on the discovery, development and commercialization of therapeutics for rare endocrine diseases and endocrine-related tumors. Its lead development candidate, PALSONIFY (paltusotine), is the first investigational once-daily, oral, selective somatostatin receptor type 2 (SST2) nonpeptide agonist that is in clinical development for acromegaly and carcinoid syndrome associated with neuroendocrine tumors. Its second product candidate is Atumelnant, which is in clinical development for congenital adrenal hyperplasia (CAH) and patients with either Cushing's disease or Ectopic ACTH Syndrome (EAS). Its drug candidates are orally delivered, small molecule new chemical entities resulting from in-house drug discovery efforts, including other programs addressing a variety of endocrine conditions such as hyperparathyroidism, polycystic kidney disease, Graves' disease, thyroid eye disease, diabetes and obesity.
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Events Timeline

(ET)
2026-06-14
17:00:00
Crinetics Pharmaceuticals Presents Atumelnant Study Data at Endocrine Society Annual Meeting
select
2026-06-14
17:00:00
Crinetics Pharmaceuticals Announces Long-Term Data for Palsonify
select
2026-05-07 (ET)
2026-05-07
17:30:00
Crinetics Q1 Revenue $10.73M, Beats Expectations
select
2026-04-27 (ET)
2026-04-27
17:20:00
Crinetics Receives EU Approval for Palsonify in Adult Acromegaly
select

News

NASDAQ.COM
9.0
06-15NASDAQ.COM
Crinetics Presents Phase 2 Data for Atumelnant at ENDO 2026
  • Clinical Trial Progress: Crinetics presented Phase 2 data for Atumelnant in congenital adrenal hyperplasia (CAH) at ENDO 2026, showing a significant 67% average reduction in A4 morning serum levels among 38 participants, indicating strong efficacy of the drug.
  • Safety Assessment: In the CAH trial, 88% of participants achieved a physiological daily dose of glucocorticoids, and Atumelnant was generally well tolerated with no treatment-related severe adverse events, highlighting its potential for clinical use.
  • Cushing's Syndrome Study: In the Phase 1b/2a study for ACTH-dependent Cushing's syndrome, Atumelnant rapidly lowered early morning serum cortisol levels over a 10-day treatment period, with 3 out of 6 participants maintaining 24-hour urine free cortisol levels below the upper limit of normal, demonstrating promising efficacy.
  • Future Development Direction: Based on these positive clinical trial results, Crinetics plans to advance Atumelnant into late-phase clinical development, further validating its application potential in treating rare endocrine diseases.
Newsfilter
2.0
06-14Newsfilter
Crinetics' Atumelnant Significantly Reduces Androgens in CAH Treatment
  • Significant Androgen Reduction: Crinetics' atumelnant demonstrated an average 67% reduction in morning serum androstenedione levels over 12 weeks in adults with classic CAH, highlighting its potential as a new treatment option for patients needing effective androgen control.
  • Glucocorticoid Dose Reduction: In the Phase 2 trial, 88% of participants maintained physiological glucocorticoid levels despite dose reductions, indicating atumelnant's efficacy in managing hormone levels without compromising treatment outcomes, enhancing its clinical applicability.
  • Rapid Cortisol Lowering: In the Phase 1b/2a trial for ACTH-dependent Cushing's syndrome, atumelnant rapidly lowered early morning serum cortisol levels within 10 days, with 3 out of 6 participants maintaining urinary free cortisol within normal limits, showcasing its therapeutic effectiveness.
  • Good Tolerability: Atumelnant exhibited good tolerability across all participants, with no severe adverse events reported, indicating its safety profile and paving the way for broader clinical use in endocrine disorders.
Newsfilter
9.5
06-14Newsfilter
PALSONIFY Shows Long-Term Efficacy in Acromegaly at ENDO 2026
  • Long-Term Efficacy: Data from the PATHFNDR-1 and PATHFNDR-2 open-label extension studies show that after two years of treatment, PALSONIFY effectively maintains IGF-1 levels and stable symptoms, highlighting its potential in treating acromegaly patients.
  • Tumor Volume Stability: In the PATHFNDR-1 study, 93% of 53 participants entered the ongoing trial, with pituitary tumor volumes remaining stable at 48 weeks, indicating PALSONIFY's effectiveness in tumor control.
  • Combination Therapy Benefits: In the ACROBAT study, the combination of PALSONIFY with oral cabergoline further improved IGF-1 levels in patients whose levels had not yet normalized, demonstrating the potential advantages of combination therapy and its good tolerability.
  • Safety Profile: Among 167 participants, the most common adverse events were diarrhea (15.6%) and arthralgia (11.4%), with no new safety signals identified, indicating that long-term use of PALSONIFY is safe.
Yahoo Finance
9.5
06-14Yahoo Finance
Crinetics Releases Long-Term Data on PALSONIFY for Acromegaly
  • Clinical Trial Results: Data from the PATHFNDR-1 and PATHFNDR-2 open-label extension studies show that after two years of treatment, PALSONIFY effectively maintained IGF-1 levels and stable symptoms, highlighting its potential in treating acromegaly patients.
  • Tumor Volume Changes: In the PATHFNDR-2 study, 114 patients had a baseline IGF-1 level of 1.64×ULN, which decreased to 1.06×ULN after 48 weeks of treatment, with 7 patients experiencing over a 20% reduction in pituitary tumor volume, demonstrating PALSONIFY's efficacy.
  • Safety Assessment: Among 167 participants, the most common adverse events included diarrhea (15.6%) and arthralgia (11.4%), with no new safety signals identified, indicating that long-term use of PALSONIFY is safe.
  • Combination Therapy Benefits: In the ACROBAT study, the combination of PALSONIFY with oral cabergoline further improved IGF-1 levels, suggesting that combination therapy may offer enhanced management options for acromegaly patients, potentially providing better treatment outcomes.
Newsfilter
8.5
06-02Newsfilter
Crinetics Presents New Data on PALSONIFY™ at ENDO 2026
  • Clinical Data Presentation: Crinetics will showcase six abstracts at the 2026 Endocrine Society Annual Meeting, including long-term safety and efficacy data for PALSONIFY™, emphasizing its best-in-class potential in treating acromegaly, which is expected to boost market confidence and drive sales growth.
  • New Drug Research Progress: Full Phase 2 study results for atumelnant will be presented, demonstrating its effectiveness in congenital adrenal hyperplasia, potentially introducing new treatment options in this field and enhancing Crinetics' competitive edge in endocrine disease management.
  • Diverse Presentation Formats: Crinetics will conduct oral reports and poster presentations covering the long-term safety and efficacy of PALSONIFY in combination with cabergoline, as well as its real-world application in managing acromegaly, further solidifying its market position.
  • Patient Engagement Activity: Crinetics will host a product theater on June 15, inviting patients to share their experiences with PALSONIFY, aiming to enhance interaction with healthcare professionals through patient stories, thereby increasing brand awareness and patient loyalty.
Yahoo Finance
8.5
06-02Yahoo Finance
Crinetics Presents New Data on PALSONIFY™ at ENDO 2026
  • Clinical Data Showcase: Crinetics will present six abstracts at the 2026 ENDO Annual Meeting, including long-term safety and efficacy data for PALSONIFY™, emphasizing its best-in-class potential in treating acromegaly, which could enhance market recognition and drive sales growth.
  • Rich Research Findings: The studies on PALSONIFY include results from open-label extension studies lasting up to two years, demonstrating its effectiveness in controlling IGF-1 levels, potentially providing patients with optimized treatment options and enhancing the company's competitiveness in the endocrine disease sector.
  • Atumelnant Progress: Crinetics will also showcase full Phase 2 study data for atumelnant in congenital adrenal hyperplasia, indicating its potential to lower glucocorticoid doses, which may offer new solutions for treating ACTH-dependent Cushing's syndrome.
  • Product Promotion Event: Crinetics will host a product theater on June 15 titled “Advancing Acromegaly Management,” which aims to enhance PALSONIFY's market awareness by bridging clinical evidence with the patient journey, thereby improving patient treatment experiences.
Wall Street analysts forecast CRNX stock price to rise
11 Analyst Rating
Wall Street analysts forecast CRNX stock price to rise
11 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
67.00
Averages
89.40
High
105.00
Current: 0.000
sliders
Low
67.00
Averages
89.40
High
105.00
Leerink
Joseph Schwartz
Outperform
maintain
AI Analysis
2026-06-11
Reason
Leerink
Joseph Schwartz
Price Target
AI Analysis
2026-06-11
maintain
Outperform
Reason
Leerink analyst Joseph Schwartz notes that Camurus received a complete response letter for Oclaiz in acromegaly. The firm sees positive readthrough to Crinetics, as the CRL at least delays a potential competitor's entry into the U.S. market during the important early innings of the Palsonify launch in acromegaly. Camurus indicated that the CRL relates to observations from a September 2024 cGMP inspection at a third-party manufacturer. This marks the second CRL for the application, with both related to a September 2024 cGMP inspection. For Crinetics, Leerink thinks the readthrough is favorable, as Palsonify should now have additional time to build physician familiarity, progress payer onboarding, and convert early patient interest without a new branded competitor entering the U.S. acromegaly market during this critical launch period. The firm reiterates an Outperform on Crinetics.
Evercore ISI
Gavin Clark-Gartner
Outperform
to
Outperform
downgrade
$89 -> $88
2026-05-15
Reason
Evercore ISI
Gavin Clark-Gartner
Price Target
$89 -> $88
2026-05-15
downgrade
Outperform
to
Outperform
Reason
Evercore ISI analyst Gavin Clark-Gartner lowered the firm's price target on Crinetics to $88 from $89 and keeps an Outperform rating on the shares.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for CRNX
Unlock Now

Valuation Metrics

The current forward P/E ratio for Crinetics Pharmaceuticals Inc (CRNX.O) is 0.00, compared to its 5-year average forward P/E of -8.33. For a more detailed relative valuation and DCF analysis to assess Crinetics Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-8.33
Current PE
0.00
Overvalued PE
-5.43
Undervalued PE
-11.22

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-5.24
Current EV/EBITDA
-1.64
Overvalued EV/EBITDA
-2.01
Undervalued EV/EBITDA
-8.46

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
943.11
Current PS
21.79
Overvalued PS
2194.16
Undervalued PS
-307.93

Financials

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Whales Holding CRNX

D
Driehaus Capital Management LLC
Holding
CRNX
+18.55%
3M Return
G
GW&K Investment Management, LLC
Holding
CRNX
+18.13%
3M Return
N
Novo Holdings A/S
Holding
CRNX
+17.23%
3M Return
F
Farallon Capital Management, L.L.C.
Holding
CRNX
+12.80%
3M Return
R
RTW Investments, LP
Holding
CRNX
+10.61%
3M Return
B
Baker Bros. Advisors LP
Holding
CRNX
+10.49%
3M Return

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Frequently Asked Questions

What is Crinetics Pharmaceuticals Inc (CRNX) stock price today?

The current price of CRNX is 35.87 USD — it has increased 0.34

What is Crinetics Pharmaceuticals Inc (CRNX)'s business?

Crinetics Pharmaceuticals, Inc. is a clinical-stage pharmaceutical company focused on the discovery, development and commercialization of therapeutics for rare endocrine diseases and endocrine-related tumors. Its lead development candidate, PALSONIFY (paltusotine), is the first investigational once-daily, oral, selective somatostatin receptor type 2 (SST2) nonpeptide agonist that is in clinical development for acromegaly and carcinoid syndrome associated with neuroendocrine tumors. Its second product candidate is Atumelnant, which is in clinical development for congenital adrenal hyperplasia (CAH) and patients with either Cushing's disease or Ectopic ACTH Syndrome (EAS). Its drug candidates are orally delivered, small molecule new chemical entities resulting from in-house drug discovery efforts, including other programs addressing a variety of endocrine conditions such as hyperparathyroidism, polycystic kidney disease, Graves' disease, thyroid eye disease, diabetes and obesity.

What is the price predicton of CRNX Stock?

Wall Street analysts forecast CRNX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for CRNX is89.40 USD with a low forecast of 67.00 USD and a high forecast of 105.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Crinetics Pharmaceuticals Inc (CRNX)'s revenue for the last quarter?

Crinetics Pharmaceuticals Inc revenue for the last quarter amounts to 10.73M USD, increased 2873.41

What is Crinetics Pharmaceuticals Inc (CRNX)'s earnings per share (EPS) for the last quarter?

Crinetics Pharmaceuticals Inc. EPS for the last quarter amounts to -1.23 USD, increased 18.27

How many employees does Crinetics Pharmaceuticals Inc (CRNX). have?

Crinetics Pharmaceuticals Inc (CRNX) has 594 emplpoyees as of June 20 2026.

What is Crinetics Pharmaceuticals Inc (CRNX) market cap?

Today CRNX has the market capitalization of 3.78B USD.