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RNA Overview

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Intellectia

Loading chart...

High
15.840
Open
14.700
VWAP
15.08
Vol
738.69K
Mkt Cap
227.60M
Low
14.600
Amount
11.14M
EV/EBITDA(TTM)
--
Total Shares
15.51M
EV
9.60B
EV/OCF(TTM)
--
P/S(TTM)
534.60
Avidity Biosciences, Inc. is a biopharmaceutical company. The Company is engaged in delivering a new class of ribonucleic acid (RNA) therapeutics called antibody oligonucleotide conjugates (AOCs). The AOCs are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies. Its advancing and expanding pipeline has three programs in clinical development. The Del-desiran is designed to treat people with myotonic dystrophy type 1 (DM1) and is in the global Phase III HARBOR trial and in the ongoing MARINA-OLE trial in people with DM1. The Delpacibart braxlosiran is the first investigational therapy designed to directly target DUX4 in people living with facioscapulohumeral muscular dystrophy (FSHD). The Del-zota is designed for people with Duchenne muscular dystrophy (DMD) and is in development with the Phase II EXPLORE44 open-label extension (OLE) study.
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Events Timeline

(ET)
2026-03-11
08:50:00
Significant Borrow Rate Increases Among Liquid Option Names
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2026-03-08 (ET)
2026-03-08
22:30:00
KKR Plans to Sell CoolIT Systems for Over $3B
select
2026-03-08
17:00:00
Dr. Vinay Prasad to Leave Agency at End of April
select
link
2026-02-27 (ET)
2026-02-27
09:30:00
Atrium Therapeutics Launches as Independent Company Focused on RNA Therapies
select
2026-02-27
09:10:00
Novartis Completes Acquisition of Avidity, Valued at Approximately $12 Billion
select
2026-02-03 (ET)
2026-02-03
05:50:00
Avidity Biosciences Sets Record Date for February 12
select

News

PRnewswire
8.5
02-27PRnewswire
Atrium Therapeutics Launches as Independent Company Advancing Precision Cardiology
  • Independent Launch: Atrium Therapeutics, Inc. officially launched today as an independent company focused on delivering RNA therapeutics for patients with rare genetic cardiomyopathies, starting with approximately $270 million in cash, marking a significant milestone in the precision cardiology sector.
  • Clinical Trial Candidates: The company's lead candidates, ATR 1072 and ATR 1086, target PRKAG2 syndrome and PLN cardiomyopathy, respectively, and are expected to enter clinical trials, addressing the unmet medical needs for effective treatments for these severe conditions.
  • Technological Platform Advantage: Atrium's RNA delivery platform combines the tissue selectivity of monoclonal antibodies with the precision of oligonucleotides, aiming to directly target the biological drivers of cardiac diseases, thereby enhancing therapeutic efficacy and overcoming limitations of traditional delivery methods.
  • Market Potential: With an estimated 1,000-2,000 patients suffering from PRKAG2 syndrome and 2,000-4,000 from PLN cardiomyopathy in the U.S., Atrium's innovative treatment solutions are poised to meet the urgent demand for effective therapies, potentially increasing the company's market share in precision cardiology.
Newsfilter
8.5
02-27Newsfilter
Atrium Therapeutics Launches as Independent Company Advancing Precision Cardiology
  • Independent Launch: Atrium Therapeutics, Inc. officially launched today as an independent company focused on delivering RNA therapeutics for patients with rare genetic cardiomyopathies, starting with approximately $270 million in cash, marking a significant milestone in precision cardiology.
  • Clinical Trial Candidates: The company's lead candidates, ATR 1072 and ATR 1086, target PRKAG2 syndrome and PLN cardiomyopathy respectively, with IND submissions expected in the second half of 2026, addressing a significant unmet need in the market with no approved therapies.
  • Platform Advantage: Atrium's RNA delivery platform combines the tissue selectivity of monoclonal antibodies with the precision of oligonucleotides, aiming to effectively target the biological drivers of cardiac diseases, thus paving the way for RNA therapies in precision cardiology with vast potential.
  • Future Development Plans: Atrium plans to initiate IND-enabling preclinical studies for ATR 1086 in 2026, targeting an IND submission in 2027, and anticipates advancing both programs into clinical trials based on Phase 1 trial results, while expanding its precision cardiology pipeline.
Benzinga
9.5
02-27Benzinga
Applied Optoelectronics Reports Strong Q4, Shares Surge
  • Earnings Beat: Applied Optoelectronics reported a fourth-quarter loss of only $0.01 per share, significantly better than the analyst consensus estimate of a $0.11 loss, indicating improvements in cost management and market demand, which boosts investor confidence.
  • Strong Sales Performance: The company achieved quarterly sales of $134.274 million, surpassing the analyst consensus estimate of $134.120 million, suggesting that its products continue to gain competitive traction in the market, potentially driving future revenue growth.
  • Stock Surge: Following the earnings report, Applied Optoelectronics shares jumped 20.4% to $64.69 in pre-market trading, reflecting market optimism about the company's future performance and likely attracting more investor interest.
  • Positive Guidance: The company issued first-quarter sales guidance above market expectations, further solidifying its market position in the optoelectronics sector and indicating stable growth potential for the upcoming quarters.
PRnewswire
2.0
02-18PRnewswire
Avidity Biosciences Reports Del-desiran Clinical Trial Results
  • Clinical Trial Results: Avidity Biosciences' del-desiran demonstrated efficacy in the Phase 1/2 MARINA trial for patients with myotonic dystrophy type 1, achieving approximately 40% mean reduction in DMPK mRNA, providing new hope for treatment.
  • Multiple Improvement Metrics: The treatment showed significant improvements across various measures including muscle function, strength, mobility, and patient-reported outcomes, indicating that del-desiran could become a transformational therapy for patients, addressing the urgent need for effective treatments.
  • Safety and Tolerability: The trial results indicated that del-desiran has an acceptable safety and tolerability profile, with most adverse events being mild or moderate, laying a solid foundation for its future clinical applications and boosting confidence among investors and patients.
  • Future Research Plans: Avidity is advancing the global Phase 3 HARBOR trial, with topline data expected in the second half of 2026, and if results are positive, it could become the first approved drug for DM1, representing significant market potential.
Newsfilter
9.0
02-18Newsfilter
Avidity Biosciences Reports Del-desiran Clinical Trial Results
  • Significant Efficacy: Del-desiran effectively delivered siRNA to muscle, resulting in an approximately 40% mean reduction in DMPK mRNA across all treated participants, indicating the potential clinical value of this therapy for myotonic dystrophy type 1 (DM1).
  • Functional Improvements: Participants exhibited significant improvements in multiple functional assessments post-treatment, including hand function, muscle strength, and activities of daily living, highlighting del-desiran's potential to enhance patient quality of life.
  • Good Safety Profile: Most treatment-emergent adverse events were mild or moderate and did not lead to participant discontinuation, indicating that del-desiran has an acceptable safety and tolerability profile, which bolsters its credibility as a potential treatment option.
  • Future Research Plans: Avidity is advancing the global Phase 3 HARBOR study, which is expected to be the first approved drug for DM1, further validating the efficacy and safety of del-desiran.
Newsfilter
8.5
02-03Newsfilter
Avidity Biosciences Announces Share Distribution for Spin-Off
  • Share Distribution Announcement: Avidity Biosciences has announced a share distribution on February 12, 2026, where holders of Avidity common stock will receive one share of Atrium Therapeutics for every ten shares held, aimed at enhancing company value through the spin-off.
  • Merger Progress: This share distribution is linked to Avidity's acquisition by Novartis, with completion contingent on specific conditions including shareholder approval, indicating the company's strategic positioning in merger integration.
  • Innovative Drug Platform: Avidity's Antibody Oligonucleotide Conjugates (AOCs™) platform is advancing clinical projects targeting rare muscle diseases, showcasing its innovative capabilities in RNA therapeutics, which could yield long-term growth potential for the company.
  • Market Outlook: Through collaboration with Novartis, Avidity plans to expand its pipeline in cardiology and immunology, further enhancing its market competitiveness and addressing the growing healthcare demands.
Wall Street analysts forecast RNA stock price to rise
9 Analyst Rating
Wall Street analysts forecast RNA stock price to rise
2 Buy
7 Hold
0 Sell
Hold
Current: 0.000
sliders
Low
72.00
Averages
75.63
High
96.00
Current: 0.000
sliders
Low
72.00
Averages
75.63
High
96.00
Wells Fargo
Yanan Zhu
Overweight
initiated
$25
AI Analysis
2026-03-10
New
Reason
Wells Fargo
Yanan Zhu
Price Target
$25
AI Analysis
2026-03-10
New
initiated
Overweight
Reason
Wells Fargo analyst Yanan Zhu initiated coverage of Atrium Therapeutics with an Overweight rating and $25 price target. The firm sees a "significant" opportunity for the company's' antibody oligonucleotide conjugates platform in genetic cardiomyopathy. Atrium's lead programs for PRKAG2 syndrome and phospholamban cardiomyopathy are addressing high unmet needs and have shown "compelling" preclinical data, the analyst tells investors in a research note.
TD Cowen
Ritu Baral
Buy -> Hold
downgrade
$78 -> $74
2025-10-28
Reason
TD Cowen
Ritu Baral
Price Target
$78 -> $74
2025-10-28
downgrade
Buy -> Hold
Reason
TD Cowen analyst Ritu Baral downgraded Avidity Biosciences (RNA) to Hold from Buy with a price target of $74, down from $78, after the company entered into a merger agreement with Novartis (NVS) for $72 per share.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for RNA
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Valuation Metrics

The current forward P/E ratio for Avidity Biosciences, Inc (RNA.O) is -13.80, compared to its 5-year average forward P/E of -7.27. For a more detailed relative valuation and DCF analysis to assess Avidity Biosciences, Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-7.27
Current PE
-13.80
Overvalued PE
-3.68
Undervalued PE
-10.86

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-4.52
Current EV/EBITDA
-12.22
Overvalued EV/EBITDA
-1.11
Undervalued EV/EBITDA
-7.92

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
245.02
Current PS
958.74
Overvalued PS
484.55
Undervalued PS
5.49

Financials

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Whales Holding RNA

P
Polar Capital Holdings Plc
Holding
RNA
+15.19%
3M Return
L
LMR Partners LLP
Holding
RNA
+12.40%
3M Return
P
Polar Asset Management Partners Inc.
Holding
RNA
+9.74%
3M Return
F
Frazier Life Sciences Management, LP
Holding
RNA
+9.72%
3M Return
T
Tudor Investment Corporation
Holding
RNA
+7.46%
3M Return
M
Magnetar Capital Partners, LP
Holding
RNA
+4.72%
3M Return

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Frequently Asked Questions

What is Avidity Biosciences, Inc (RNA) stock price today?

The current price of RNA is 14.8 USD — it has increased 0.89

What is Avidity Biosciences, Inc (RNA)'s business?

Avidity Biosciences, Inc. is a biopharmaceutical company. The Company is engaged in delivering a new class of ribonucleic acid (RNA) therapeutics called antibody oligonucleotide conjugates (AOCs). The AOCs are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies. Its advancing and expanding pipeline has three programs in clinical development. The Del-desiran is designed to treat people with myotonic dystrophy type 1 (DM1) and is in the global Phase III HARBOR trial and in the ongoing MARINA-OLE trial in people with DM1. The Delpacibart braxlosiran is the first investigational therapy designed to directly target DUX4 in people living with facioscapulohumeral muscular dystrophy (FSHD). The Del-zota is designed for people with Duchenne muscular dystrophy (DMD) and is in development with the Phase II EXPLORE44 open-label extension (OLE) study.

What is the price predicton of RNA Stock?

Wall Street analysts forecast RNA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for RNA is75.63 USD with a low forecast of 72.00 USD and a high forecast of 96.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Avidity Biosciences, Inc (RNA)'s revenue for the last quarter?

Avidity Biosciences, Inc revenue for the last quarter amounts to 859.00K USD, decreased -71.11

What is Avidity Biosciences, Inc (RNA)'s earnings per share (EPS) for the last quarter?

Avidity Biosciences, Inc. EPS for the last quarter amounts to -1.70 USD, increased 153.73

How many employees does Avidity Biosciences, Inc (RNA). have?

Avidity Biosciences, Inc (RNA) has 47 emplpoyees as of March 11 2026.

What is Avidity Biosciences, Inc (RNA) market cap?

Today RNA has the market capitalization of 227.60M USD.