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MBX Overview

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$
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0.000(0.000%)
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0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
28.915
Open
28.400
VWAP
28.20
Vol
434.38K
Mkt Cap
1.35B
Low
27.250
Amount
12.25M
EV/EBITDA(TTM)
--
Total Shares
47.51M
EV
989.84M
EV/OCF(TTM)
--
P/S(TTM)
--
MBX Biosciences, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on the discovery and development of novel precision peptide therapies for the treatment of endocrine and metabolic disorders. It has built its proprietary Precision Endocrine Peptide platform to develop precision peptide therapies that are designed to overcome key limitations of current peptide therapies. Its product candidates and programs include MBX 2109, MBX 1416 and Obesity portfolio. MBX 2109 is a parathyroid hormone peptide prodrug that is designed as a potential long-acting hormone replacement therapy for the treatment of chronic hypoparathyroidism. MBX 1416 is designed to be a long-acting glucagon-like peptide-1 (GLP-1), receptor antagonist, as a potential therapy for post-bariatric hypoglycemia, a chronic complication of bariatric surgery. MBX 4291 is designed to be a long-acting and highly potent GLP-1 and glucose-dependent insulinotropic polypeptide, receptor co-agonist prodrug.
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Events Timeline

(ET)
2026-03-12
16:20:00
MBX Biosciences Files Automatic Mixed Securities Shelf
select
2026-03-12
08:10:00
MBX Biosciences CEO Discusses Clinical Progress in 2025
select
2026-03-10 (ET)
2026-03-10
08:20:00
MBX Biosciences Appoints Karen Basbaum as Chief Business Officer
select
2026-03-09 (ET)
2026-03-09
08:10:00
MBX Biosciences Completes FDA Meeting, Advances Phase 3 Trial for Chronic Hypoparathyroidism
select
2026-01-22 (ET)
2026-01-22
08:20:00
MBX Biosciences Appoints Laurie Stelzer as Independent Director
select
2026-01-11 (ET)
2026-01-11
17:20:00
MBX Biosciences Updates 2026 Outlook
select
2026-01-11
17:20:00
Estimated $373.7 Million Cash to Fund Operations into 2029 as of December 31, 2025
select

News

seekingalpha
9.5
03-12seekingalpha
MBX Biosciences Reports Q4 2025 Financial Results
  • Financial Performance: MBX Biosciences reported a GAAP EPS of -$0.49 for Q4 2025, indicating ongoing challenges in profitability and reflecting competitive pressures in the market.
  • Cash Position: As of December 31, 2025, MBX had cash, cash equivalents, and marketable securities totaling $373.7 million, and subsequently raised an additional $85.4 million through its ATM program on February 4, 2026, enhancing liquidity.
  • Net Loss Analysis: The net loss for Q4 2025 was $22.1 million, compared to a net loss of $15.6 million in the same period of 2024, highlighting difficulties in cost control and revenue generation.
  • Annual Loss Comparison: The total net loss for 2025 reached $87.0 million, significantly up from $61.9 million in 2024, indicating that the company needs to implement more effective strategies for business expansion and profitability.
NASDAQ.COM
2.0
03-09NASDAQ.COM
Mbx Biosciences Shares Hit Oversold Signal
  • Oversold Signal: Mbx Biosciences Inc (Ticker: MBX) saw its RSI drop to 29.1 during Monday's trading, indicating an oversold condition as shares hit a low of $27.98, suggesting that the recent heavy selling may be nearing exhaustion, prompting bullish investors to consider buying opportunities.
  • Market Comparison: Compared to the S&P 500 ETF (SPY) with an RSI of 44.9, MBX's 29.1 RSI indicates relative weakness, potentially attracting investors looking for rebounds, especially amid increasing market volatility.
  • Historical Performance: MBX's 52-week low stands at $4.8069 per share, with a high of $44.89, and the last trade at $27.94 reflects significant price fluctuations over the past year, necessitating careful risk assessment by investors.
  • Investor Sentiment: Although the current stock price is in the oversold territory, investor sentiment may be influenced by short-term market fluctuations, requiring close monitoring of future market trends to determine entry points.
Newsfilter
9.0
03-09Newsfilter
MBX Biosciences Completes EOP2 Meeting with FDA for Canvuparatide
  • Successful EOP2 Meeting: MBX Biosciences successfully completed an End-of-Phase 2 meeting with the FDA, discussing the Phase 3 trial design for canvuparatide aimed at chronic hypoparathyroidism, marking a significant milestone in the drug development process.
  • Phase 3 Trial Design: The planned Phase 3 trial, set to initiate in Q3 2026, will enroll approximately 160 patients randomized in a 3:1 ratio to evaluate the efficacy and safety of canvuparatide, potentially offering patients a more convenient treatment option.
  • Drug Design Advantages: Canvuparatide is designed as a long-acting hormone replacement therapy that aims to restore physiological PTH activity with a once-weekly dosing regimen, which is expected to significantly enhance patients' quality of life and meet the urgent market demand for new treatment options.
  • Orphan Drug Designation: The drug has received orphan drug designation from the European Medicines Agency, further supporting its clinical development in Europe and demonstrating MBX's strategic focus on the global market and chronic hypoparathyroidism.
Newsfilter
9.0
03-09Newsfilter
MBX Biosciences Completes FDA Meeting, Advances New Drug Trial
  • Clinical Trial Progress: MBX Biosciences successfully completed an End-of-Phase 2 meeting with the FDA to discuss the Phase 3 trial design for canvuparatide, marking a significant milestone in the company's drug development journey.
  • Patient Recruitment Plan: The company plans to initiate recruitment of approximately 160 patients for a Phase 3 double-blind placebo-controlled trial in Q3 2026, with a 3:1 randomization ratio aimed at assessing the efficacy and safety of canvuparatide.
  • Drug Design Advantages: Canvuparatide is designed as a long-acting hormone replacement therapy that aims to restore physiological PTH activity through a convenient once-weekly dosing regimen, which is expected to set a new standard of care for hypoparathyroidism, addressing patient needs for less burdensome treatment options.
  • European Market Recognition: The drug has received orphan drug designation from the European Medicines Agency, further supporting its clinical development in Europe and demonstrating MBX's potential for global market expansion.
Yahoo Finance
2.0
02-21Yahoo Finance
Overview of 13D Filings
  • Definition of 13D Filings: 13D filings are disclosures required to be submitted to the SEC within 10 days when an entity acquires more than 5% of any class of a company's securities, aimed at enhancing market transparency.
  • Purpose of Disclosure: The primary purpose of these filings is to inform investors about the holdings of major shareholders and their potential impact on corporate governance and strategic decisions, thereby aiding market participants in making more informed investment choices.
  • Compliance Requirements: Under U.S. securities law, any investor holding more than 5% must timely submit a 13D filing to ensure that all market participants have access to relevant information, thus maintaining market fairness.
  • Market Impact: The disclosure of 13D filings can trigger market interest in the related companies, influencing their stock price volatility, especially when investors speculate on the intentions and future plans of major shareholders.
NASDAQ.COM
8.5
01-29NASDAQ.COM
Analyst Target Prices Indicate Potential for Pharmaceuticals ETF
  • ETF Upside Potential: The iShares U.S. Pharmaceuticals ETF (IHE) has an implied analyst target price of $96.28 per unit, while trading at $86.15, indicating an 11.76% upside, reflecting market optimism about the ETF's future performance.
  • MBX Stock Analysis: MBX BIOSCIENCES INC (MBX) trades at $35.83, with an analyst target price of $60.55, suggesting a potential upside of 69.01%, showcasing investor confidence in its future prospects.
  • CRNX Stock Outlook: Crinetics Pharmaceuticals Inc (CRNX) has a current price of $51.32 and an analyst target of $83.46, indicating a 62.63% upside, reflecting positive market sentiment regarding its product and R&D advancements.
  • XERS Investment Opportunity: Xeris Biopharma Holdings Inc (XERS) is priced at $7.14, with an analyst target of $11.14, showing a 56.05% upside, indicating analysts' optimism about its growth potential.
Wall Street analysts forecast MBX stock price to rise
8 Analyst Rating
Wall Street analysts forecast MBX stock price to rise
7 Buy
0 Hold
1 Sell
Strong Buy
Current: 0.000
sliders
Low
31.97
Averages
59.33
High
80.00
Current: 0.000
sliders
Low
31.97
Averages
59.33
High
80.00
Barclays
Overweight
initiated
$66
AI Analysis
2026-01-27
Reason
Barclays
Price Target
$66
AI Analysis
2026-01-27
initiated
Overweight
Reason
Barclays initiated coverage of MBX Biosciences with an Overweight rating and $66 price target. Barclays initiated coverage of 12 biotech stocks and assumed coverage of 11 with a positive view of the industry. The analyst likes the setup for the group in 2026. Many biotech stocks remain undervalued, the analyst tells investors in a research note. The firm expects continued mergers and acquisitions, "strong" underlying fundamentals, and less of a focus on drug pricing to act as "significant tailwinds."
Guggenheim
Buy
maintain
$77 -> $88
2026-01-16
Reason
Guggenheim
Price Target
$77 -> $88
2026-01-16
maintain
Buy
Reason
Guggenheim raised the firm's price target on MBX Biosciences to $88 from $77 and keeps a Buy rating on the shares after the company reiterated plans to release Phase 1b data in Q4 for its once-monthly obesity drug MBX 4291. The firm now "conservatively" forecasts non-risk adjusted sales of $1.6B in 2040 for MBX 4291 and a "modest" odds of success of 20%.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for MBX
Unlock Now

Valuation Metrics

The current forward P/E ratio for MBX Biosciences Inc (MBX.O) is -9.62, compared to its 5-year average forward P/E of -5.81. For a more detailed relative valuation and DCF analysis to assess MBX Biosciences Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-5.81
Current PE
-9.62
Overvalued PE
-3.23
Undervalued PE
-8.40

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-3.05
Current EV/EBITDA
-7.06
Overvalued EV/EBITDA
-0.23
Undervalued EV/EBITDA
-5.87

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
0.00
Current PS
0.00
Overvalued PS
0.00
Undervalued PS
0.00

Financials

AI Analysis
Annual
Quarterly

Whales Holding MBX

T
TCG Crossover Management, LLC
Holding
MBX
+0.43%
3M Return
K
Kynam Capital Management, LP
Holding
MBX
-0.06%
3M Return
E
EcoR1 Capital, LLC
Holding
MBX
-0.80%
3M Return
B
Braidwell LP
Holding
MBX
-1.16%
3M Return
F
Frazier Life Sciences Management, LP
Holding
MBX
-1.16%
3M Return
O
OrbiMed Advisors LLC
Holding
MBX
-4.95%
3M Return

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Frequently Asked Questions

What is MBX Biosciences Inc (MBX) stock price today?

The current price of MBX is 28.43 USD — it has decreased -0.94

What is MBX Biosciences Inc (MBX)'s business?

MBX Biosciences, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on the discovery and development of novel precision peptide therapies for the treatment of endocrine and metabolic disorders. It has built its proprietary Precision Endocrine Peptide platform to develop precision peptide therapies that are designed to overcome key limitations of current peptide therapies. Its product candidates and programs include MBX 2109, MBX 1416 and Obesity portfolio. MBX 2109 is a parathyroid hormone peptide prodrug that is designed as a potential long-acting hormone replacement therapy for the treatment of chronic hypoparathyroidism. MBX 1416 is designed to be a long-acting glucagon-like peptide-1 (GLP-1), receptor antagonist, as a potential therapy for post-bariatric hypoglycemia, a chronic complication of bariatric surgery. MBX 4291 is designed to be a long-acting and highly potent GLP-1 and glucose-dependent insulinotropic polypeptide, receptor co-agonist prodrug.

What is the price predicton of MBX Stock?

Wall Street analysts forecast MBX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for MBX is59.33 USD with a low forecast of 31.97 USD and a high forecast of 80.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is MBX Biosciences Inc (MBX)'s revenue for the last quarter?

MBX Biosciences Inc revenue for the last quarter amounts to -25.80M USD, increased 38.61

What is MBX Biosciences Inc (MBX)'s earnings per share (EPS) for the last quarter?

MBX Biosciences Inc. EPS for the last quarter amounts to -19094000.00 USD, increased 18.38

How many employees does MBX Biosciences Inc (MBX). have?

MBX Biosciences Inc (MBX) has 63 emplpoyees as of March 20 2026.

What is MBX Biosciences Inc (MBX) market cap?

Today MBX has the market capitalization of 1.35B USD.