What’s Behind the Surge in Caribou Biosciences Stock Today?
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 03 2025
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Source: Benzinga
Caribou Biosciences Stock Surge: Caribou Biosciences Inc. (NASDAQ: CRBU) experienced a stock increase of 17.56% after announcing promising results from its CAR-T therapy for advanced B-cell lymphoma, showing a 64% complete response rate in patients.
ANTLER Phase 1 Trial Results: The ongoing ANTLER phase 1 trial of vispacabtagene regedleucel (vispa-cel) demonstrated an overall response rate of 82% and a one-year progression-free survival rate of 51%, confirming its efficacy compared to traditional autologous CAR-T therapies.
CB-011 Clinical Data: Caribou also reported positive results from the CaMMouflage Phase 1 trial of CB-011, an anti-BCMA CAR-T therapy for multiple myeloma, with a 92% overall response rate and 75% complete response rate, alongside a manageable safety profile.
Future Plans: The FDA has advised Caribou to conduct a randomized controlled trial for vispa-cel in specific patient populations, and the company plans to initiate a dose expansion for CB-011 by the end of the year, with data expected in 2026.
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Analyst Views on CRBU
Wall Street analysts forecast CRBU stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for CRBU is 8.00 USD with a low forecast of 6.00 USD and a high forecast of 10.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
5 Analyst Rating
5 Buy
0 Hold
0 Sell
Strong Buy
Current: 1.520
Low
6.00
Averages
8.00
High
10.00
Current: 1.520
Low
6.00
Averages
8.00
High
10.00
About CRBU
Caribou Biosciences, Inc. is a clinical-stage clustered regularly interspaced short palindromic repeats (CRISPR) genome-editing biopharmaceutical company engaged in developing transformative therapies for patients with devastating diseases. The Company’s genome-editing platform, including its Cas12a chRDNA technology, enables superior precision to develop cell therapies that are armored to potentially improve activity against disease. Caribou is advancing a pipeline of off-the-shelf cell therapies from its CAR-T platform to offer broad access and rapid availability of treatments for patients with hematologic malignancies and autoimmune diseases. Its genome-editing platform, including its novel chRDNA technology, enables more precise genome editing of allogeneic cell therapies. It is advancing its pipeline of allogeneic CAR-T cell therapies with clinical development programs targeting the treatment of hematologic malignancies and autoimmune diseases.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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Caribou Biosciences Hosts Panel on vispa-cel to Broaden Patient Access for CAR-T Therapy
- Expert Panel Discussion: Caribou Biosciences will host a panel on December 6, 2025, to discuss how vispa-cel can promote CAR-T therapy in community hospitals, thereby expanding patient access and enhancing the company's influence in oncology treatment.
- Clinical Trial Progress: As of September 2025, 84 patients have been treated in the ANTLER trial, demonstrating that vispa-cel's safety and efficacy are comparable to autologous CAR-T therapies, which is expected to bolster the company's competitive position in the market.
- Innovative Treatment Approach: Vispa-cel is the first allogeneic CAR-T therapy in clinical use with a PD-1 knockout, aimed at improving therapeutic efficacy, potentially transforming the treatment landscape for patients with large B-cell lymphoma and increasing market appeal for the company's products.
- Regulatory Recognition: The FDA has granted vispa-cel several key designations, including Regenerative Medicine Advanced Therapy (RMAT) and Orphan Drug status, further enhancing its market potential and investment attractiveness.
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