Vyome Holdings Publishes Preclinical Data for VT-1908
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 1 day ago
0mins
Should l Buy HIND?
Vyome Holdings announced the publication of its preclinical data validating the efficacy and safety of VT-1908 as a potential treatment for uveitis in the peer-reviewed Journal of Ophthalmic Inflammation and Infection, a Springer-Nature journal. Uveitis refers to the immune-inflammation of the eye, and accounts for 10%-15% of all cases of blindness in the developed world. In the United States alone, it is associated with an estimated 30,000 new cases of legal blindness annually, and represents an estimated $3B market opportunity by 2032. In this publication, topical eye drops of VT-1908 resulted in the desired concentration of the active drug being achieved in the eye without any irritation or signs of toxicity. VT-1908-treated eyes showed a significant reduction in the uveitis score with reduced lymphocyte counts in the anterior chamber compared to vehicle control. VT-1908 was found to be as effective as topical prednisone in the preclinical model.
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About HIND
Vyome Holdings, Inc. is a clinical-stage healthcare holding company. The Company is focused on leveraging its clinical-stage assets to transform the lives of patients with immuno-inflammatory conditions. Its clinical program VT1953 Gel is focused on cancer patients who are suffering from malignant fungating wounds (MFW). Its preclinical development program, VT1908, is a non-steroidal eye drop, which is focused on Uveitis. Its other business unit is focused on offering artificial intelligence (AI)-driven healthcare solutions across mental health and inflammation care, digital therapeutics and psychoneuroimmunology.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Vyome Publishes Preclinical Data for VT-1908
- Preclinical Data Release: Vyome Holdings, Inc. published preclinical data in the Journal of Ophthalmic Inflammation and Infection, validating the efficacy and safety of VT-1908 for treating uveitis, highlighting its potential as a steroid alternative to meet the urgent market demand for safe therapies.
- Significant Market Opportunity: Uveitis accounts for 10-15% of blindness cases in developed countries, with an estimated market opportunity of $3 billion by 2032, positioning VT-1908 for a substantial market share if successfully developed.
- Clinical Development Plans: Vyome intends to leverage the India innovation corridor to advance VT-1908 into clinical development in a highly cost-efficient manner, aiming to generate critical human clinical data that could lead to significant value inflection for the company.
- Focus on Core Programs: While advancing the Phase 3 study of VT-1953, Vyome maintains its capital deployment plan unchanged, ensuring resources are concentrated on the treatment of malignant fungating wounds, which represents a $2.2 billion market opportunity in the U.S.
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Vyome's VT-1953 Treatment Significantly Improves Malodor in Malignant Wounds
- Clinical Trial Success: Vyome's VT-1953 treatment achieved statistically significant improvements in malodor associated with malignant wounds within 14 days (P=0.002), laying the groundwork for entering a $1 billion market opportunity.
- Quality of Life Enhancement: The significant improvement in the patient-reported impact of malodor on quality of life (P=0.0256) not only boosts patient mental health but also potentially enhances Vyome's competitive position in the market.
- Pain Relief Effectiveness: VT-1953 demonstrated significant pain reduction (P=0.002), indicating its potential in improving overall patient health outcomes and satisfaction.
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Vyome Publishes Preclinical Data for VT-1908
- Preclinical Data Release: Vyome Holdings, Inc. published preclinical data in the Journal of Ophthalmic Inflammation and Infection, validating the efficacy and safety of VT-1908 for treating uveitis, highlighting its potential as a steroid alternative to meet the urgent market demand for safe therapies.
- Significant Market Opportunity: Uveitis accounts for 10-15% of blindness cases in developed countries, with an estimated market opportunity of $3 billion by 2032, positioning VT-1908 for a substantial market share if successfully developed.
- Clinical Development Plans: Vyome intends to leverage the India innovation corridor to advance VT-1908 into clinical development in a highly cost-efficient manner, aiming to generate critical human clinical data that could lead to significant value inflection for the company.
- Focus on Core Programs: While advancing the Phase 3 study of VT-1953, Vyome maintains its capital deployment plan unchanged, ensuring resources are concentrated on the treatment of malignant fungating wounds, which represents a $2.2 billion market opportunity in the U.S.
See More
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- Annual Reinvested Distributions: Harvest Portfolios Group has announced the final annual reinvested distributions for its ETFs for the 2025 tax year, with all distributions being non-cash, ensuring that the number of units held and the net asset value of the ETFs remain unchanged, thereby maintaining asset stability for investors.
- Tax Implications Explained: The distributions will be reported as taxable, which will increase each unitholder's adjusted cost base, impacting future tax handling and ensuring investors are aware of their tax responsibilities.
- Distribution Details Update: All final reinvested capital gain and income distributions for Harvest ETFs are reported as zero, reflecting the company's cautious strategy in the current market environment aimed at protecting investor interests.
- Enhanced Information Transparency: Harvest commits to reporting the actual taxable amounts and nature of distributions to brokers through CDS in early 2026, enhancing transparency and aiding investors in making informed decisions.
See More
Harvest Announces Final Annual Reinvested Distributions for 2025 Tax Year
- Reinvestment Distribution Announcement: Harvest Portfolios Group Inc. announces the final annual reinvested distributions for its ETFs for the 2025 tax year, with all distributions being non-cash, ensuring that the number of units held and the net asset value of the ETFs remain unchanged.
- Tax Implications Explained: The distributions will be reported as taxable, expected to be communicated to brokers through CDS in early 2026, which will increase each unitholder's adjusted cost base and impact future tax considerations.
- Distribution Details Update: All Harvest ETFs report zero reinvested capital gain and income distributions, indicating no distributable earnings for the year, which may affect investor return expectations.
- Record Date Set: December 31, 2025, is established as the ex-dividend date for all unitholders of record, ensuring investors are informed of distribution details to make timely investment decisions.
See More
Harvest ETFs Updates 2025 Estimated Reinvested Distributions
- Distribution Amount Revision: Harvest has announced a revision of the estimated reinvested distributions for 2025, which will be reported to brokers through CDS in early 2026, ensuring investors are informed about tax implications.
- Non-Cash Distribution Mechanism: The annual distributions for all Harvest ETFs will be reinvested in a non-cash format, ensuring that the number of units held and the net asset value remain unchanged, thereby maintaining asset stability for investors.
- Tax Implications Explained: The reinvested distributions will be treated as taxable distributions, increasing each unitholder's adjusted cost base, which will impact future tax planning.
- Final Distribution Announcement: Harvest expects to announce the final year-end reinvested distribution amounts around December 31, 2025, ensuring investors receive timely access to critical information.
See More
Vyome's VT-1953 Treatment Significantly Improves Malodor in Malignant Wounds
- Clinical Trial Success: Vyome's VT-1953 treatment achieved statistically significant improvements in malodor associated with malignant wounds within 14 days (P=0.002), laying the groundwork for entering a $1 billion market opportunity.
- Quality of Life Enhancement: The significant improvement in the patient-reported impact of malodor on quality of life (P=0.0256) not only boosts patient mental health but also potentially enhances Vyome's competitive position in the market.
- Pain Relief Effectiveness: VT-1953 demonstrated significant pain reduction (P=0.002), indicating its potential in improving overall patient health outcomes and satisfaction.
- Future Development Plans: Vyome aims to initiate a Phase III clinical trial in 2026 to further advance VT-1953 towards FDA approval, reflecting the company's confidence in the product and its market prospects.
See More
Harvest ETFs Reveals Distribution Plans for November 2025
Monthly Distributions Announcement: Harvest Portfolios Group Inc. has announced monthly distributions for various Harvest ETFs for November 2025, with payments scheduled for December 5, 2025, to unitholders of record on November 28, 2025.
Distribution Details: The distributions vary by ETF, with amounts ranging from $0.0250 to $0.4300 per unit, depending on the specific ETF and its currency denomination.
Estimated Distribution for Canadian T-Bill ETF: An estimated distribution of $0.0935 per unit for the Harvest Canadian T-Bill ETF will also be paid on December 5, 2025, with the final amount to be confirmed on November 27, 2025.
Company Background: Harvest Portfolios Group Inc., founded in 2009, manages over $9.6 billion in assets and focuses on long-term wealth preservation through high-quality business investments, utilizing various covered call strategies across its ETFs.
See More
