Tivic Health Systems Rebrands to Valion Bio
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Apr 23 2026
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Should l Buy TIVC?
Tivic Health Systems announced it is changing its corporate name to "Valion Bio" and its Nasdaq ticker symbol from "TIVC" to "VBIO," effective at market open on Tuesday, April 28. The CUSIP number for the company's common stock will remain unchanged. The rebrand is not merely cosmetic. It reflects the completion of a fundamental strategic transformation - the deliberate unwinding of a consumer medical device business and its replacement with a focused late-stage biopharmaceutical platform anchored by a government-priority asset with over 15 years and more than $140M in cumulative development investment, and supported by a wholly owned biomanufacturing subsidiary.
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Analyst Views on TIVC
About TIVC
Valion Bio, Inc., formerly Tivic Health Systems, Inc., is a late-stage immunotherapeutics company. The Company offers Entolimod, which is a drug used to treat acute radiation syndrome (ARS). Entolimod is a toll-like receptor 5 (TLR5) agonist that activates an innate immune pathway to prevent cell death in the bone marrow and epithelial tissues across systems impacted by radiation and age. Its pipeline also includes Entolimod to treat neutropenia and lymphocyte exhaustion, as well as Entolasta, an immunologically optimized variant of Entolimod for chronic applications. Its subsidiary, Velocity Bioworks, is a full-service contract development and manufacturing organization (CDMO) that is based in San Antonio, Texas. It offers upstream and downstream process development and optimization; analytical testing, assay development, and qualification; quality control and stability testing; microbial and mammalian expression systems; technology transfer and program management services.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Tivic Health Selected for U.S. Department of Defense Tech Watch Program
- Presentation Opportunity: Tivic Health Systems is set to present its Entolimod™ TLR5 agonist at the U.S. Department of Defense's Tech Watch program on May 7, 2026, indicating potential new collaboration opportunities in defense and dual-use technologies.
- Innovative Delivery Method: The company is exploring an oral transmucosal delivery formulation aimed at enhancing the speed and stability of Entolimod™, which could significantly improve survival rates in combat and mass casualty scenarios, addressing urgent medical needs.
- Shifting Market Demand: As geopolitical dynamics evolve, governments are reassessing their medical preparedness, positioning Tivic Health's technology as a potential cornerstone of national and allied defense stockpiles, thereby enhancing the company's strategic market position.
- Clinical Research Advancements: Entolimod™ has demonstrated survival benefits in animal models and received Fast Track and Orphan Drug designations from the FDA, highlighting its potential in treating acute radiation syndrome and strengthening the company's competitive edge in the biopharmaceutical sector.
See More
Tivic Health Systems Reports FY 2025 Financial Overview
- Rising Operating Expenses: Tivic Health's operating expenses for FY 2025 are projected to reach $7.9 million, significantly up from $4.5 million in 2024, indicating ongoing investments in business expansion and R&D that may pressure short-term profitability.
- Increased Net Loss: The expected net loss for 2025 is between $8.8 million and $9.1 million, compared to $5.7 million in 2024, raising concerns among investors regarding the company's financial health, which could negatively impact stock performance.
- Improved Cash Position: The company anticipates cash and working capital of $12.6 million and $12.4 million in 2025, a substantial increase from $2.0 million in 2024, reflecting positive progress in cash management and liquidity that supports future operations and investments.
- Market Opportunity Outlook: Following its strategic transformation, Tivic Health has identified a $20 billion oncology market opportunity, indicating potential for expansion into new market segments that could lay the groundwork for future growth.
See More
Tivic Health Transforms into Immunotherapy Company
- Strategic Transformation: Under CEO Michael Handley's leadership, Tivic Health has fully pivoted to immunotherapy, focusing on the TLR5 platform with candidates like Entolimod and Entolasta, targeting the oncology supportive care market projected to grow from $15 billion to $20 billion.
- In-House Manufacturing: The company has completed its acquisition of in-house manufacturing capabilities and launched Velocity Bioworks, which is expected to provide cost efficiencies and a new revenue stream, significantly reducing development timelines and costs for Entolimod while enhancing supply chain control.
- Improved Financial Position: As of December 31, 2025, Tivic's cash and cash equivalents totaled $12.6 million, a substantial increase from $2 million in 2024, indicating improved financial health following new business lines and acquisitions.
- Market Opportunities: Tivic is actively engaging with U.S. government agencies for potential biodefense contracts and plans to initiate clinical trials for Entolimod within the year, showcasing the company's strong potential and readiness in the biotherapeutics market.
See More
TIVIC HEALTH SYSTEMS INC - MAKES PROGRESS ON ENTOLIMOD PLATFORM FOR POSSIBLE FUNDING PARTNERSHIPS
- Advancements in Health Systems: Tivic Health Systems continues to make progress in enhancing its health technology platform.
- Focus on Funding Partnerships: The company is actively seeking potential funding partnerships to support its growth and development initiatives.
See More
Davis Commodities Reports $95M Revenue in H1, Up 42.1%
- Significant Revenue Growth: Davis Commodities Ltd reported a revenue of $95 million for the first half ending June 30, marking a 42.1% increase from $66.9 million a year earlier, indicating strong performance in the agricultural commodity trading sector and boosting market confidence.
- Stock Price Surge: Following the earnings report, Davis Commodities' shares jumped 5.6% to $0.25 in pre-market trading, reflecting investor optimism regarding the company's future growth potential.
- Positive Market Reaction: The stock price increase post-earnings release indicates market recognition of Davis Commodities' performance, which may attract more investor interest and further drive the stock price upward.
- Optimistic Industry Outlook: With the ongoing demand for agricultural commodities, the strong earnings report not only enhances Davis Commodities' market position but also potentially provides funding for future expansion and investments.
See More
Tivic Grows Its Intellectual Property Assets
New Patent Applications: Tivic Health Systems has filed two patent applications, one for TLR5 agonists like Entolimod and Entolasta to enhance cancer therapy outcomes, and another for optimized specifications of a non-invasive vagus nerve stimulation device.
Potential Benefits for Cancer Patients: The TLR5 agonists may serve as adjunctive therapies to improve the effectiveness of immuno-oncology treatments for late-stage cancer patients who are often immunocompromised.
Focus on Intellectual Property and Partnerships: CEO Jennifer Ernst emphasized the importance of expanding their intellectual property rights to create new partnership opportunities and market potential for their product candidates.
Overview of Tivic's Therapeutics: Tivic Health utilizes both biopharmaceutical and bioelectronic systems to address unmet medical needs, with a focus on enhancing immune responses and developing non-invasive medical devices for various diseases.
See More
Tivic Health Selected for U.S. Department of Defense Tech Watch Program
- Presentation Opportunity: Tivic Health Systems is set to present its Entolimod™ TLR5 agonist at the U.S. Department of Defense's Tech Watch program on May 7, 2026, indicating potential new collaboration opportunities in defense and dual-use technologies.
- Innovative Delivery Method: The company is exploring an oral transmucosal delivery formulation aimed at enhancing the speed and stability of Entolimod™, which could significantly improve survival rates in combat and mass casualty scenarios, addressing urgent medical needs.
- Shifting Market Demand: As geopolitical dynamics evolve, governments are reassessing their medical preparedness, positioning Tivic Health's technology as a potential cornerstone of national and allied defense stockpiles, thereby enhancing the company's strategic market position.
- Clinical Research Advancements: Entolimod™ has demonstrated survival benefits in animal models and received Fast Track and Orphan Drug designations from the FDA, highlighting its potential in treating acute radiation syndrome and strengthening the company's competitive edge in the biopharmaceutical sector.
See More
Tivic Health Systems Reports FY 2025 Financial Overview
- Rising Operating Expenses: Tivic Health's operating expenses for FY 2025 are projected to reach $7.9 million, significantly up from $4.5 million in 2024, indicating ongoing investments in business expansion and R&D that may pressure short-term profitability.
- Increased Net Loss: The expected net loss for 2025 is between $8.8 million and $9.1 million, compared to $5.7 million in 2024, raising concerns among investors regarding the company's financial health, which could negatively impact stock performance.
- Improved Cash Position: The company anticipates cash and working capital of $12.6 million and $12.4 million in 2025, a substantial increase from $2.0 million in 2024, reflecting positive progress in cash management and liquidity that supports future operations and investments.
- Market Opportunity Outlook: Following its strategic transformation, Tivic Health has identified a $20 billion oncology market opportunity, indicating potential for expansion into new market segments that could lay the groundwork for future growth.
See More
Tivic Health Transforms into Immunotherapy Company
- Strategic Transformation: Under CEO Michael Handley's leadership, Tivic Health has fully pivoted to immunotherapy, focusing on the TLR5 platform with candidates like Entolimod and Entolasta, targeting the oncology supportive care market projected to grow from $15 billion to $20 billion.
- In-House Manufacturing: The company has completed its acquisition of in-house manufacturing capabilities and launched Velocity Bioworks, which is expected to provide cost efficiencies and a new revenue stream, significantly reducing development timelines and costs for Entolimod while enhancing supply chain control.
- Improved Financial Position: As of December 31, 2025, Tivic's cash and cash equivalents totaled $12.6 million, a substantial increase from $2 million in 2024, indicating improved financial health following new business lines and acquisitions.
- Market Opportunities: Tivic is actively engaging with U.S. government agencies for potential biodefense contracts and plans to initiate clinical trials for Entolimod within the year, showcasing the company's strong potential and readiness in the biotherapeutics market.
See More
TIVIC HEALTH SYSTEMS INC - MAKES PROGRESS ON ENTOLIMOD PLATFORM FOR POSSIBLE FUNDING PARTNERSHIPS
- Advancements in Health Systems: Tivic Health Systems continues to make progress in enhancing its health technology platform.
- Focus on Funding Partnerships: The company is actively seeking potential funding partnerships to support its growth and development initiatives.
See More
Davis Commodities Reports $95M Revenue in H1, Up 42.1%
- Significant Revenue Growth: Davis Commodities Ltd reported a revenue of $95 million for the first half ending June 30, marking a 42.1% increase from $66.9 million a year earlier, indicating strong performance in the agricultural commodity trading sector and boosting market confidence.
- Stock Price Surge: Following the earnings report, Davis Commodities' shares jumped 5.6% to $0.25 in pre-market trading, reflecting investor optimism regarding the company's future growth potential.
- Positive Market Reaction: The stock price increase post-earnings release indicates market recognition of Davis Commodities' performance, which may attract more investor interest and further drive the stock price upward.
- Optimistic Industry Outlook: With the ongoing demand for agricultural commodities, the strong earnings report not only enhances Davis Commodities' market position but also potentially provides funding for future expansion and investments.
See More
Tivic Grows Its Intellectual Property Assets
New Patent Applications: Tivic Health Systems has filed two patent applications, one for TLR5 agonists like Entolimod and Entolasta to enhance cancer therapy outcomes, and another for optimized specifications of a non-invasive vagus nerve stimulation device.
Potential Benefits for Cancer Patients: The TLR5 agonists may serve as adjunctive therapies to improve the effectiveness of immuno-oncology treatments for late-stage cancer patients who are often immunocompromised.
Focus on Intellectual Property and Partnerships: CEO Jennifer Ernst emphasized the importance of expanding their intellectual property rights to create new partnership opportunities and market potential for their product candidates.
Overview of Tivic's Therapeutics: Tivic Health utilizes both biopharmaceutical and bioelectronic systems to address unmet medical needs, with a focus on enhancing immune responses and developing non-invasive medical devices for various diseases.
See More
