Sol-Gel Technologies Halts SGT-210 Development, Shifts Focus to Other Studies
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 17 2025
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Source: Newsfilter
- Clinical Trial Results: Sol-Gel's Phase 1b study of SGT-210 did not demonstrate efficacy over the vehicle control, leading to the decision to halt further development, marking a significant setback in treating Darier disease.
- Resource Reallocation: The company plans to conduct small, low-cost feasibility studies to explore SGT-210's application in other areas of unmet medical need, aiming to recover investment losses through new research directions.
- Focus on Key Projects: Sol-Gel continues to prioritize the Phase 3 trial of SGT-610, which has the potential to be the first treatment for preventing basal cell carcinoma in Gorlin syndrome patients, demonstrating the company's ongoing commitment to dermatological therapies.
- Market Challenges: With Gorlin syndrome affecting approximately 1 in 27,000 to 31,000 people in the U.S., despite significant market potential, Sol-Gel faces intense industry competition and resource constraints that may impact its future market performance.
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Analyst Views on SLGL
Wall Street analysts forecast SLGL stock price to fall over the next 12 months. According to Wall Street analysts, the average 1-year price target for SLGL is 50.00 USD with a low forecast of 50.00 USD and a high forecast of 50.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
1 Analyst Rating
1 Buy
0 Hold
0 Sell
Moderate Buy
Current: 60.850
Low
50.00
Averages
50.00
High
50.00
Current: 60.850
Low
50.00
Averages
50.00
High
50.00
About SLGL
Sol-Gel Technologies Ltd is a clinical-stage dermatology company. The Company is focused on identifying, developing and commercializing branded and generic topical drug products for the treatment of skin diseases. The Company’s offers a range of products twins, sirs-t, and vered. The Company is designed its proprietary, silica-based microencapsulation technology platform to enhance the tolerability and stability of topical drugs while maintaining their efficacy. Topical drugs often struggle to balance achieving both high efficacy and high tolerability. Its technology platform entraps active ingredients in an inert, inorganic silica shell, which creates an unnoticeable barrier between the active ingredient and the skin.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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What’s Causing the Decline of Small Cap Sol-Gel Tech Stock Today?
Clinical Study Update: Sol-Gel Technologies announced that the Phase 1b study of SGT-210 for Darier disease did not show efficacy compared to the vehicle, leading to a decision not to advance further in this indication. The company plans to conduct small feasibility studies in other areas of unmet medical need.
Focus on Other Programs: The Executive Chairman, Mori Arkin, emphasized the company's commitment to completing the Phase 3 program for SGT-610 in Gorlin syndrome and preparing for a potential Phase 3 program in high-frequency basal cell carcinoma, contingent on the success of the Gorlin trial.
Stock Performance Analysis: Sol-Gel Technologies (SLGL) is currently showing strong technical indicators, trading above key moving averages, with a bullish trend supported by positive momentum in the MACD and a neutral RSI.
Recent Stock Movement: SLGL stock experienced a decline of 6.81% to $39.26, while over the past year, it has gained 735.02%, indicating a strong upward trajectory but caution is advised as it approaches resistance levels.
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