Perceptive Advisors Increases Stake in Celcuity
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 1 hour ago
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Should l Buy CELC?
Source: NASDAQ.COM
- Share Increase: Perceptive Advisors purchased an additional 203,881 shares of Celcuity in Q4, with an estimated trade value of $16.76 million, indicating strong confidence in the company, especially as its stock has surged 700% over the past year.
- Position Value Growth: The fund's position in Celcuity reached 3,160,200 shares valued at approximately $315.20 million at quarter-end, reflecting a $169.16 million increase, which underscores market recognition of the company's future potential.
- FDA Review Progress: Celcuity's New Drug Application for gedatolisib has been accepted by the FDA for Priority Review, with a PDUFA goal date of July 17, 2026; if approved, it will enter a substantial breast cancer market with significant potential.
- Investor Attention: Despite the dramatic 700% increase in Celcuity's stock price, long-term investors should monitor the company's execution capabilities and commercialization readiness to maintain a competitive edge in the future market.
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Analyst Views on CELC
Wall Street analysts forecast CELC stock price to fall
9 Analyst Rating
8 Buy
1 Hold
0 Sell
Strong Buy
Current: 106.780
Low
94.00
Averages
106.50
High
126.00
Current: 106.780
Low
94.00
Averages
106.50
High
126.00
About CELC
Celcuity Inc. is a clinical-stage biotechnology company, which develops targeted therapies for the treatment of multiple solid tumor indications. Its lead therapeutic candidate is gedatolisib, a potent, small-molecule reversible inhibitor that selectively targets all Class I isoforms of phosphatidylinositol-3-kinase (PI3K) and the two mechanistic targets of rapamycin (mTOR) sub-complexes, mTORC1 and mTORC2. Its development programs for gedatolisib focus on the treatment of patients with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-), or HR+/HER2-, advanced or metastatic breast cancer and patients with metastatic castration resistant prostate cancer. A Phase III clinical trial of VIKTORIA-1, evaluating gedatolisib in combination with fulvestrant with or without palbociclib in patients with HR+/HER2- advanced breast has commenced. Its CELsignia companion diagnostic platform is able to analyze live patient tumor cells.
About the author

Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
- Stake Increase: Perceptive Advisors acquired an additional 203,881 shares of Celcuity in Q4 2026, with an estimated transaction value of $16.76 million, indicating strong conviction in the company, especially given its 700% stock price surge over the past year.
- Ownership Proportion Rise: Following this purchase, Perceptive Advisors' stake in Celcuity increased to 5.62%, reflecting its significant emphasis on the company within its portfolio and reinforcing Celcuity's position among its top five holdings.
- Market Performance: As of February 17, 2026, Celcuity shares were priced at $107.32, with a market capitalization of $4.97 billion; despite a net loss of $162.72 million over the past year, the company's market potential continues to attract investor interest.
- FDA Review Progress: Celcuity's New Drug Application for gedatolisib has been accepted by the FDA for Priority Review, with a goal date of July 17, 2026; if approved, this could provide significant commercial opportunities in the competitive breast cancer market, further enhancing its stock price and market position.
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- Share Acquisition Details: Perceptive Advisors increased its stake in Praxis Precision Medicines by 431,432 shares during Q4 2025, with an estimated transaction value of $80.34 million, reflecting strong confidence in the company's future prospects.
- Position Value Growth: Following this acquisition, the value of Praxis's holdings reached $588.30 million, an increase of $505.38 million from the previous quarter-end, indicating significant stock price appreciation and positive investor sentiment.
- Financial Overview: As of February 17, 2026, Praxis shares were priced at $328.04, up 320% year-over-year, despite a net loss of $273.04 million in 2025, suggesting market optimism regarding its future product pipeline.
- R&D and Market Outlook: Praxis has submitted two NDAs to the FDA and is actively preparing for commercialization, with multiple clinical trial results expected in 2026, which could further enhance its market position in the central nervous system sector.
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- Stake Increase: Perceptive Advisors purchased an additional 203,881 shares of Celcuity in Q4 2026, with an estimated transaction value of $16.76 million, indicating strong confidence in the company's future growth potential.
- Ownership Proportion Rise: Following this purchase, Perceptive Advisors' stake in Celcuity increased to 5.62%, highlighting its significance within the investment portfolio and further drawing market attention to Celcuity.
- Market Performance: As of February 17, 2026, Celcuity shares were priced at $107.32, reflecting a staggering 700% increase over the past year, underscoring strong market anticipation for its drug development.
- FDA Review Progress: Celcuity's new drug application for gedatolisib has received Priority Review from the FDA, with a decision expected by July 17, 2026, a critical timeline that could significantly impact its future market performance.
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- Share Increase: Perceptive Advisors purchased an additional 203,881 shares of Celcuity in Q4, with an estimated trade value of $16.76 million, indicating strong confidence in the company, especially as its stock has surged 700% over the past year.
- Position Value Growth: The fund's position in Celcuity reached 3,160,200 shares valued at approximately $315.20 million at quarter-end, reflecting a $169.16 million increase, which underscores market recognition of the company's future potential.
- FDA Review Progress: Celcuity's New Drug Application for gedatolisib has been accepted by the FDA for Priority Review, with a PDUFA goal date of July 17, 2026; if approved, it will enter a substantial breast cancer market with significant potential.
- Investor Attention: Despite the dramatic 700% increase in Celcuity's stock price, long-term investors should monitor the company's execution capabilities and commercialization readiness to maintain a competitive edge in the future market.
See More
- Options Selling Risk: Selling put options does not provide investors with the upside potential of owning shares, as the seller only acquires shares if the contract is exercised, meaning they only profit if the stock declines by 58% from the current price.
- Yield Analysis: Under current market conditions, selling the January 2028 put at a $45 strike offers a 9.2% annualized return, indicating that the seller's only profit comes from the premium collected, rather than any potential appreciation of the stock.
- Volatility Consideration: Celcuity Inc's trailing twelve-month volatility stands at 120%, and when combined with fundamental analysis, it can help investors assess whether selling this put option is a worthwhile risk under the current market environment.
- Market Trading Dynamics: On Friday, the put volume among S&P 500 components reached 1.33 million contracts, matching call volume, resulting in a put:call ratio of 0.73, indicating a higher-than-normal demand for puts compared to the long-term median of 0.65, reflecting a shift in market sentiment.
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- Share Increase: Soleus Capital Management disclosed a purchase of 629,398 shares of Celcuity in an SEC filing, raising its total holdings to over 1.8 million shares valued at $180.36 million, indicating strong confidence in the company.
- Asset Allocation Shift: Celcuity now accounts for 6.7% of Soleus Capital's AUM, becoming its third-largest holding among 95 positions, reflecting investor interest in the biotechnology sector.
- Stock Performance: Celcuity's stock price surged 745% over the past year, significantly outperforming the S&P 500's 14.4% and NASDAQ Composite's 15.7%, highlighting strong market expectations for its future potential.
- Risk Advisory: Despite Celcuity's impressive stock performance, the company currently generates no revenue, necessitating caution from investors regarding inherent risks, as the stock's value is heavily reliant on drug approvals and future profitability prospects.
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