NRx Amends NRX-101 Filing to Enhance Depression Treatment with TMS
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 03 2025
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Source: Globenewswire
- Clinical Trial Advancement: NRx has amended its Investigational New Drug filing for NRX-101 to include its use with Transcranial Magnetic Stimulation (TMS) for depression treatment, which is expected to significantly enhance clinical response rates to 75% and remission rates to 40%, indicating substantial market potential.
- Market Potential: By 2030, over 1 million Americans are projected to receive TMS treatment annually, creating a new market opportunity for NRX-101 that may exceed previous company expectations.
- Drug Combination Advantage: NRX-101 combines low-dose D-cycloserine with lurasidone, with clinical trials showing over two-fold improvement in depression symptoms and fewer side effects, positioning it as a potential standard therapy in conjunction with TMS.
- Expanded Access Policy: NRx has published an Expanded Access policy allowing physicians to provide NRX-101 to patients in need, further enhancing the company's competitive position in the depression treatment market.
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Analyst Views on NRXP
Wall Street analysts forecast NRXP stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for NRXP is 37.67 USD with a low forecast of 25.00 USD and a high forecast of 48.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
3 Analyst Rating
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 2.110
Low
25.00
Averages
37.67
High
48.00
Current: 2.110
Low
25.00
Averages
37.67
High
48.00
About NRXP
NRx Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company developing therapeutics based on its N-methyl-D-aspartate (NMDA) platform for the treatment of central nervous system disorders, specifically suicidal depression, chronic pain, and PTSD. It is developing NRX-100 (preservative-free intravenous ketamine) and NRX-101, (oral D-cycloserine/lurasidone). NRX-100 has been awarded Fast Track Designation for the treatment of Suicidal Ideation in Depression, including Bipolar Depression. NRX-101 has been awarded Breakthrough Therapy Designation for the treatment of suicidal bipolar depression. NRx has filed an Abbreviated New Drug Application (ANDA) and initiated a New Drug Application filing for NRX-100 (IV ketamine) with an application for the Commissioner’s National Priority Voucher Program for the treatment of suicidal depression. Its subsidiary, HOPE Therapeutics, Inc., is a healthcare delivery company that is building a network of interventional psychiatry clinics.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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