IGC Pharma Reaches 65% Enrollment Milestone in Phase 2 CALMA Trial for Alzheimer's Agitation
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 10 2025
0mins
Should l Buy IGC?
Source: NASDAQ.COM
Trial Progress: IGC Pharma has achieved 65% patient enrollment in its Phase 2 CALMA trial for IGC-AD1, aimed at treating agitation in Alzheimer's disease, with a target of 146 participants.
Agitation in Alzheimer's: Agitation affects over 76% of Alzheimer's patients, leading to significant distress for both patients and caregivers, highlighting the need for new treatment options.
Therapeutic Potential: Interim analyses of IGC-AD1 have shown significant reductions in agitation, indicating its potential as a novel therapy for Alzheimer's dementia.
Recruitment Strategy: The trial's enrollment has been enhanced through a hybrid strategy, with 25% of participants recruited via social media and 75% through clinical sites, aiming for full enrollment by early 2026.
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Analyst Views on IGC
Wall Street analysts forecast IGC stock price to rise
1 Analyst Rating
1 Buy
0 Hold
0 Sell
Moderate Buy
Current: 0.319
Low
4.75
Averages
4.75
High
4.75
Current: 0.319
Low
4.75
Averages
4.75
High
4.75
No data
About IGC
IGC Pharma, Inc. is a clinical-stage biotechnology company leveraging artificial intelligence (AI) to develop treatments for Alzheimer's and metabolic disorders. The Company's lead asset, IGC-AD1, is a cannabinoid-based therapy is in a Phase 2 trial (CALMA) for agitation in Alzheimer's dementia. The Company’s pipeline includes TGR-63, targeting amyloid plaques, and early-stage programs focused on neurodegeneration, tau proteins, and metabolic dysfunctions. The Company integrates AI to accelerate drug discovery, optimize clinical trials, and enhance patient targeting. It is also developing a Multimodal Interpretable Transformer for Alzheimer’s Disease (MINT-AD). MINT-AD leverages diverse data sources, including brain scans, genetics, lifestyle, and cognitive metrics, to produce clinically interpretable risk profiles and forecast decline trajectories.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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