Dyne Therapeutics Prices Upsized Public Offering of 18.98 Million Shares, Raising $350 Million
- Upsized Offering: Dyne Therapeutics announced the pricing of an upsized public offering of 18,980,478 shares at $18.44 per share, expected to raise $350 million, significantly enhancing the company's financial capacity to support its therapeutic development for genetically driven neuromuscular diseases.
- Strong Underwriter Lineup: The offering is managed by a robust team including Morgan Stanley, Jefferies, Stifel, and Guggenheim Securities, reflecting strong market confidence in Dyne and potentially enhancing the company's reputation and attractiveness in capital markets.
- Timely Transaction: The offering is expected to close on or about December 11, 2025, subject to customary closing conditions, ensuring that funds are rapidly available to support the advancement of the company's clinical programs.
- Strategic Development Focus: Dyne is dedicated to developing therapeutics targeting muscle and the central nervous system, with proceeds from the offering aimed at advancing clinical programs for myotonic dystrophy and Duchenne muscular dystrophy, further solidifying its market position in the biopharmaceutical sector.
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Dyne Therapeutics Receives Orphan Drug Designation for z-basivarsen, ACHIEVE Trial Shows Sustained Improvement
- Clinical Trial Progress: Z-basivarsen demonstrates sustained functional improvement in the ACHIEVE trial, particularly in muscle strength and function, with enrollment for the registrational expansion cohort expected to complete in early Q2 2026, further advancing treatment options.
- Orphan Drug Designation: The MHLW in Japan has granted z-basivarsen orphan drug status for myotonic dystrophy type 1 (DM1), highlighting the urgent need for new therapies and potentially providing up to 10 years of market exclusivity if approved.
- Multiple Designations: Z-basivarsen has received Breakthrough Therapy, Fast Track, and Orphan Drug designations from the FDA, along with Orphan Drug designation from the EMA, indicating its development potential and market recognition on a global scale.
- Treatment Need: DM1 affects approximately 40,000 people in the U.S. and 55,000 in the EU, and the development of z-basivarsen aims to address the significant unmet medical need, carrying important social and economic implications.

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