Corbus Pharmaceuticals' CRB-913 Achieves 2.9% Weight Loss in Obese Patients
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 11 2025
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Source: Newsfilter
- Clinical Trial Success: Corbus has completed the single ascending dose (SAD) and multiple ascending dose (MAD) Phase 1a studies of CRB-913, with all doses being safe and well-tolerated, and no serious adverse events reported, indicating a strong safety profile.
- Significant Weight Loss Effect: In the 150 mg cohort, all CRB-913-treated participants (n=9) achieved a mean weight loss of 2.9% by Day 14, while none in the placebo group (n=3) lost weight, highlighting the drug's potential in obesity management.
- Follow-up Research Plans: Corbus has initiated the 12-week Phase 1b CANYON-1 study, targeting 240 obese, non-diabetic participants, with completion expected in summer 2026, to further validate the efficacy of CRB-913.
- Broad Market Potential: As a peripherally restricted CB1 inverse agonist with reduced brain penetration, CRB-913 may offer a new treatment option for obesity, particularly when used in combination with existing therapies, presenting significant market opportunities.
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Analyst Views on CRBP
Wall Street analysts forecast CRBP stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for CRBP is 46.71 USD with a low forecast of 38.00 USD and a high forecast of 53.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
8 Analyst Rating
8 Buy
0 Hold
0 Sell
Strong Buy
Current: 8.700
Low
38.00
Averages
46.71
High
53.00
Current: 8.700
Low
38.00
Averages
46.71
High
53.00
About CRBP
Corbus Pharmaceuticals Holdings, Inc. is an oncology and obesity company. The Company has a diversified portfolio and is committed to helping people defeat serious illness by bringing scientific approaches to well-understood biological pathways. The Company’s oncology pipeline comprises two experimental drugs targeting solid tumors: CRB-701, an antibody drug conjugate (ADC) that targets the expression of Nectin-4 on cancer cells to release a cytotoxic payload, and CRB-601, an anti-integrin monoclonal antibody that blocks the activation of TGFB expressed on cancer cells. CRB-701 is a monoclonal antibody attached to a monomethyl auristatin E (MMAE) cytotoxic payload using a proprietary linker technology. The pipeline also includes CRB-913, a highly peripherally restricted cannabinoid type-1 (CB1) receptor inverse agonist for the treatment of obesity. CB1 inverse agonism is a clinically validated mechanism to induce weight loss.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Corbus Pharmaceuticals: 46% Stake Held by Retail Investors Influencing Management
- Retail Influence: Corbus Pharmaceuticals has 46% of its shares held by retail investors, indicating significant influence over management and strategic decisions, which could drive the company towards more public-interest-aligned directions.
- Institutional Participation: Institutional investors own 23% of the company, which brings credibility from professional investors but also raises the risk of a 'crowded trade' in a company lacking a growth history.
- Hedge Fund Role: Hedge funds hold 24% of the shares and may attempt to influence management to create short-term value, particularly driven by major shareholders like Cormorant Asset Management and OrbiMed Advisors.
- Insider Ownership: Insiders own less than 1% of the company, which may challenge other shareholders in holding management accountable for decisions, especially given the market capitalization of only $156 million.
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