Centessa Pharmaceuticals' Cleminorexton Receives FDA Orphan Designation
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jun 04 2026
0mins
Centessa Pharmaceuticals' cleminorexton was granted FDA orphan designation as a treatment of idiopathic hypersomnia, according to a post to the agency's website.
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Analyst Views on CNTA
Wall Street analysts forecast CNTA stock price to fall
13 Analyst Rating
13 Buy
0 Hold
0 Sell
Strong Buy
Current: 39.870
Low
27.00
Averages
38.75
High
62.00
Current: 39.870
Low
27.00
Averages
38.75
High
62.00
About CNTA
Centessa Pharmaceuticals plc is a clinical-stage pharmaceutical company. The Company is developing a new class of potential therapies within its orexin receptor 2 (OX2R) agonist program for the treatment of excessive daytime sleepiness (EDS), impaired attention, cognitive deficits, fatigue and other symptoms across neurological, neurodegenerative and neuropsychiatric disorders. It also has an early-stage immuno-oncology program focused on its LockBody technology platform. Its OX2R agonist pipeline includes ORX750, its advanced OX2R agonist development candidate, and ORX142, ORX489 and OX2R agonists in preclinical development. Its ORX750, an investigational, orally administered, highly potent and selective OX2R agonist, is in a Phase IIa study of participants with narcolepsy type 1 (NT1), NT2 and idiopathic hypersomnia (IH). ORX142 is the second OX2R agonist development candidate being advanced for the treatment of neurological and neurodegenerative disorders and other symptoms.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Increasing Deal Sizes: The average deal size has climbed to $527.3 million in 2026, up from $365 million in 2025, indicating that pharmaceutical firms are focusing on acquiring high-value assets to enhance their product portfolios and competitive positioning in the market.
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- Acquisition Strategy Shift: Lilly has already announced acquisition amounts exceeding last year's total of $4 billion, indicating a strategic shift from early-stage assets to more promising experimental drugs aimed at enhancing long-term growth.
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- UniFirst Acquisition Details: UniFirst Corporation is being sold to Cintas Corporation for $155.00 in cash and 0.7720 shares of Cintas stock per UniFirst share, potentially limiting superior competing offers.
- Centessa Pharmaceuticals Deal: Centessa Pharmaceuticals plc is selling to Eli Lilly for $38.00 in cash per share plus a non-transferable contingent value right that could yield up to $9.00 upon achieving certain milestones, prompting shareholders to consider their rights.
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- Green Dot Transaction Structure: Green Dot Corporation's sale price includes $8.11 in cash and 0.2215 shares of a new publicly traded bank holding company for each share, with Halper Sadeh LLC representing shareholders to negotiate better terms and transparency.
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