BrainStorm Secures Key Manufacturing Partnership with Minaris for Upcoming NurOwn® Phase 3b ALS Clinical Trials
Partnership Announcement: BrainStorm Cell Therapeutics has signed a Letter of Intent with Minaris Advanced Therapies to manufacture its investigational therapy NurOwn® for an upcoming Phase 3b clinical trial, enhancing its manufacturing capabilities in the U.S.
Therapeutic Overview: NurOwn® utilizes autologous mesenchymal stem cells to produce neurotrophic factor-secreting cells aimed at treating neurodegenerative diseases like ALS, and has received Orphan Drug designation from both the FDA and EMA.
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- Significant Market Potential: Pluri Inc.'s regenerative aesthetic products are expected to enter the U.S. market in 2026, coinciding with projections that the U.S. medical aesthetics market will reach $90 billion by 2030, indicating robust growth potential.
- Product Launch Progress: Cellav Health and Aesthetics Ltd. has completed the development and U.S. cosmetic product listings for Regenativo+ and Placento+, marking a significant step in the company's commercialization efforts in the U.S. market.
- Clinical Validation Support: The ingredients in Cellav's products have shown statistically significant improvements in skin elasticity and firmness, reinforcing its premium positioning in the professional regenerative and longevity sectors.
- Strategic Partnership Opportunities: Cellav is actively engaging with U.S. distributors and clinic networks to establish strategic partnerships and expand market share, aiming to drive future commercial growth.
- Chairman's Investment: Pluri Inc. announced that its Chairman Alejandro Weinstein has entered into a Securities Purchase Agreement for an additional $2.5 million investment, executed at a 30% premium to the market price on March 24, 2026, reflecting his strong confidence in the company's long-term value creation potential.
- Investment Context: This additional investment follows Weinstein's prior $2.5 million investment, underscoring his recognition of Pluri's unique asset and technology combination, aimed at unlocking the company's potential value through focused execution and strategic prioritization.
- Financing Details: The private placement consists of 625,000 common shares and warrants to purchase an equal number of shares, with a purchase price of $4.00 per share and an exercise price of $4.25 for the warrants, expected to generate approximately $2.5 million in gross proceeds for the company.
- Use of Funds: Pluri intends to utilize the proceeds from this financing for general working capital and corporate purposes, further advancing its innovations in regenerative medicine, foodtech, and agtech sectors.

- Manufacturing Capability Enhancement: Pluri's collaboration with Remedy Cell successfully integrates its proprietary manufacturing process into Pluri's GMP facility, marking the completion of clinical-grade batch production that supports Remedy Cell's initial Phase 1b clinical trial, showcasing the strong synergy in biopharmaceutical development between the two companies.
- Clinical Trial Preparation: The successful manufacture of several clinical-grade batches signifies significant progress for Remedy Cell in its clinical development for treating complex fibrotic diseases, further advancing the clinical application of its secretome-based therapies to meet the urgent market demand for innovative treatment options.
- Expanded Collaboration Scope: PluriCDMO™ will continue to provide additional manufacturing and process development support for Remedy Cell, underscoring their shared commitment to advancing next-generation cell-free biologics that address significant unmet medical needs.
- Successful Technology Implementation: The successful execution of GMP training and engineering runs by Pluri's CDMO division not only enhances the robustness and scalability of the manufacturing process but also solidifies Pluri's position as a trusted partner for complex cell-derived therapies.

Launch of Cellav: Pluri Inc. has launched Cellav Health and Aesthetics Ltd., a subsidiary focused on developing advanced exosome-based technologies for medical aesthetics using Pluri's proprietary 3D cell expansion platform.
Collaboration with Miss Universe Skincare: Cellav has secured a partnership with Miss Universe Skincare to co-develop a new line of cell-based skincare products, with the first product expected to launch in the first half of 2026.
Market Potential: The beauty market is projected to reach $194.05 billion by 2032, highlighting the significant growth opportunity for Cellav's innovative skincare solutions.
Leadership and Vision: Cellav is led by CEO Katty Dowery, who emphasizes the integration of advanced biotechnology into everyday beauty products, aiming to make regenerative science accessible and impactful.

Financial Performance: Plurilock Security Inc. reported a 159% increase in Critical Services revenue year-over-year and a 42% improvement in Adjusted EBITDA loss for Q2 2025 compared to the same period in 2024.
Revenue Breakdown: Total revenue for Q2 2025 was CAD 16.4 million, with significant contributions from professional services and software sales, while hardware sales decreased as a percentage of total revenue.
Operational Highlights: The company secured new contracts worth CAD 5.9 million across federal and public sector clients and expanded its presence in NATO and other international defense markets.
Future Outlook: Plurilock aims to continue its growth strategy focused on higher-margin offerings and is well-positioned to benefit from increased government spending in cybersecurity and defense sectors.

Partnership Announcement: BrainStorm Cell Therapeutics has signed a Letter of Intent with Minaris Advanced Therapies to manufacture its investigational therapy NurOwn® for an upcoming Phase 3b clinical trial, enhancing its manufacturing capabilities in the U.S.
Therapeutic Overview: NurOwn® utilizes autologous mesenchymal stem cells to produce neurotrophic factor-secreting cells aimed at treating neurodegenerative diseases like ALS, and has received Orphan Drug designation from both the FDA and EMA.





