Argenx Suspends Phase 3 Trial for Thyroid Eye Disease, Opening Opportunities for Competitors Like Viridian Therapeutics
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 15 2025
0mins
Source: Benzinga
Discontinuation of Phase 3 Studies: Argenx SE has decided to halt the Phase 3 UplighTED studies of efgartigimod for moderate to severe thyroid eye disease after an Independent Data Monitoring Committee recommended stopping the trials for futility based on interim analysis data.
Safety Profile: Despite the discontinuation, efgartigimod demonstrated a favorable safety and tolerability profile, with no new safety signals identified during the trials.
Future Data Analysis: Following the closure of the studies, Argenx plans to conduct a comprehensive analysis of the collected data, which will be shared at a future medical meeting.
Market Impact: The announcement surprised analysts, with some noting that the news could positively affect the IGF-1R antibody class, while Argenx shares fell by nearly 5% following the news.
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Analyst Views on VRDN
Wall Street analysts forecast VRDN stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for VRDN is 41.71 USD with a low forecast of 14.20 USD and a high forecast of 61.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
17 Analyst Rating
17 Buy
0 Hold
0 Sell
Strong Buy
Current: 33.570
Low
14.20
Averages
41.71
High
61.00
Current: 33.570
Low
14.20
Averages
41.71
High
61.00
About VRDN
Viridian Therapeutics, Inc. is a biopharmaceutical company focused on engineering and developing potential medicines for patients with serious and rare diseases. The Company is advancing multiple candidates in the clinic for the treatment of patients with thyroid eye disease (TED). The Company is conducting two global Phase 3 clinical trials (THRIVE and THRIVE-2) to evaluate the safety and efficacy of veligrotug in patients with active and chronic TED. It is also conducting two global Phase 3 clinical trials, REVEAL-1 and REVEAL-2, to evaluate the efficacy and safety of VRDN-003 in patients. Its advanced program, veligrotug, is a differentiated humanized monoclonal antibody targeting IGF-1R intravenously administered for the treatment of TED. In addition to its TED portfolio, the Company is advancing a novel portfolio of neonatal Fc receptor (FcRn) inhibitors, including VRDN-006 and VRDN-008, which has the potential to be developed in multiple autoimmune diseases.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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