Alumis Inc. (ALMS) Reports 65% PASI 90 Achievement for Envudeucitinib in Psoriasis Trials
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 14 2026
0mins
Source: NASDAQ.COM
- Clinical Trial Success: Alumis' Envudeucitinib demonstrated impressive results in the ONWARD1 and ONWARD2 trials, with approximately 65% of patients achieving PASI 90 and over 40% reaching PASI 100 at 24 weeks, indicating its potential in psoriasis treatment and likely significant market share gains for the company.
- Market Opportunity: As the only TYK2 inhibitor, Envudeucitinib stands out in a limited competitive landscape, particularly following Bristol Myers Squibb's Sotyktu, which generated $170 million in 2023 and $246 million in 2024, highlighting the growth potential in this sector.
- FDA Application Plans: Alumis plans to submit a New Drug Application for Envudeucitinib to the FDA in the second half of this year, which, if approved, would further solidify its position in the psoriasis treatment market and potentially drive stock price increases.
- Long-term Research Progress: The ONWARD3 study for Envudeucitinib is ongoing to assess its long-term effects, and the drug is also undergoing a phase 2b trial for systemic lupus erythematosus, with topline data expected in Q3 2026, further expanding its indications.
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Analyst Views on ALMS
Wall Street analysts forecast ALMS stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ALMS is 37.67 USD with a low forecast of 32.00 USD and a high forecast of 50.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
6 Analyst Rating
6 Buy
0 Hold
0 Sell
Strong Buy
Current: 27.710
Low
32.00
Averages
37.67
High
50.00
Current: 27.710
Low
32.00
Averages
37.67
High
50.00
About ALMS
Alumis Inc. is a late-stage biopharmaceutical company. The Company is engaged in developing next-generation targeted therapies with the potential to significantly improve patient health and outcomes across a range of immune-mediated diseases. Leveraging its proprietary data analytics platform and precision approach, the Company is developing a pipeline of oral tyrosine kinase 2 (TYK2) inhibitors, consisting of ESK-001 for the treatment of systemic immune-mediated disorders, such as moderate-to-severe plaque psoriasis and systemic lupus erythematosus, and A-005 for the treatment of neuroinflammatory and neurodegenerative diseases such as multiple sclerosis and Parkinson’s Disease. In addition, its pipeline also includes lonigutamab, a subcutaneously delivered anti-insulin-like growth factor 1 receptor therapy for the treatment of thyroid eye disease, as well as several preclinical programs identified through this precision approach.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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Alumis Director Srinivas Akkaraju Purchases 588,235 Shares for ~$10 Million
- Large Transaction: On January 9, 2026, Srinivas Akkaraju purchased 588,235 shares of Alumis at $17 per share for a total of approximately $10 million, marking one of the largest trades in his history and exceeding the historical median trade size by nearly 47%.
- Increased Indirect Holdings: Following this transaction, Akkaraju's indirect holdings rose to 1,853,488 shares, reflecting his confidence in Alumis's future growth, particularly as the company's stock has surged over 400% in the past year.
- Market Price Comparison: The acquisition price was below the market open of $18.50 and close of $19.56 on January 9, 2026, indicating a favorable entry point for Akkaraju ahead of subsequent price increases, suggesting expectations of further appreciation.
- Clinical Trial Success: Alumis recently reported that 65% of patients in two Phase 3 trials with envudeucitinib achieved a 90% or better improvement in their psoriasis area and severity index (PASI) scores, indicating superior efficacy compared to Amgen's Otezla, further boosting market confidence in its products.
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