Actinium Presents New ATNM-400 Breast Cancer Data Showing Potent Efficacy
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 12 2025
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Source: Newsfilter
- Potent Anti-Tumor Activity: ATNM-400 demonstrated significant tumor growth inhibition across various breast cancer models, particularly in hormone receptor-positive and triple-negative types, with all treatment regimens well tolerated and no significant weight changes observed, indicating its potential for clinical application.
- Efficacy in Resistant Models: In trastuzumab- and tamoxifen-resistant breast cancer cells, ATNM-400 exhibited enhanced cytotoxicity, and combining it with standard treatments resulted in greater cytotoxicity and tumor regression, showcasing its promise as a combination therapy.
- Mechanistic Evidence of DNA Damage: Treatment with ATNM-400 led to irreversible double-strand DNA breaks in breast cancer cells, activating AKT phosphorylation, which indicates its effective mechanism in resistant models and may provide new options for treating hard-to-treat breast cancer.
- Broad Applicability: Beyond breast cancer, ATNM-400 has shown potential efficacy in prostate cancer and non-small cell lung cancer, supporting its development as a multi-indication targeted radiotherapy to meet clinical needs.
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Analyst Views on ATNM
Wall Street analysts forecast ATNM stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ATNM is 6.00 USD with a low forecast of 4.00 USD and a high forecast of 9.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
3 Analyst Rating
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 1.220
Low
4.00
Averages
6.00
High
9.00
Current: 1.220
Low
4.00
Averages
6.00
High
9.00
About ATNM
Actinium Pharmaceuticals, Inc. specializes in the development of targeted radiotherapies. The Company is advancing its lead product candidate Actimab-A, a CD33 targeting therapeutic, as potential backbone therapy in acute myeloid leukemia (AML) and other myeloid malignancies leveraging the mutation agnostic alpha-emitter radioisotope payload Actinium-225 (Ac-225). The Company is engaged with the National Cancer Institute (NCI) under the Cooperative Research and Development Agreement (CRADA) for development of Actimab-A in AML and other myeloid malignancies. ATNM-400 is the Company's novel non-PSMA targeting Ac-225 radiotherapy for prostate cancer. Iomab-ACT, its conditioning candidate, is being developed to improve patient access and outcomes for potentially curative cell and gene therapies. Its Iomab-B program is an induction and conditioning agent prior to bone marrow transplant in patients with r/r AML, which it is seeking a potential strategic partner for the United States.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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