Acrivon Therapeutics (ACRV) Shares Plunge 28.71% Following Mixed Phase 2b Clinical Results
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 08 2026
0mins
Source: NASDAQ.COM
- Stock Volatility: Acrivon Therapeutics shares plummeted 28.71% after the release of updated clinical trial results for ACR-368, dropping from an opening price of $2.95 to $2.10, indicating investors' heightened sensitivity to clinical outcomes.
- Clinical Results Analysis: Despite a promising overall confirmed response rate of 52% in patients with the serous subtype of endometrial cancer, mixed interpretations of the data led to shaken market confidence, adversely affecting stock performance.
- Trial Expansion Plans: Acrivon announced plans to expand the trial into the European Union to accelerate patient enrollment, a strategic move aimed at enhancing the trial's effectiveness and market acceptance, although the stock remains under pressure in the short term.
- Surge in Trading Volume: The trading volume significantly exceeded average levels, reflecting investors' strong reactions to the clinical results, highlighting the high volatility and uncertainty prevalent in the biotech sector.
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Analyst Views on ACRV
Wall Street analysts forecast ACRV stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ACRV is 10.50 USD with a low forecast of 7.00 USD and a high forecast of 19.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
6 Analyst Rating
5 Buy
1 Hold
0 Sell
Strong Buy
Current: 1.890
Low
7.00
Averages
10.50
High
19.00
Current: 1.890
Low
7.00
Averages
10.50
High
19.00
About ACRV
Acrivon Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing precision oncology medicines. It uses its precision Generative Phosphoproteomics platform, Acrivon Predictive Precision Proteomics (AP3), to develop its pipeline of oncology drug candidates. Its lead candidate, ACR-368, is a selective small molecule inhibitor which targets CHK1 and CHK2 at sub single-digit nM and single-digit nM potency in intact cells, respectively, in a registrational Phase II trial across multiple solid tumor types. Using its AP3 platform, it has developed a predictive OncoSignature test for ACR-368, called ACR-368 OncoSignature, that can predict patient response to ACR-368 monotherapy and therefore improve the clinical overall response rate (ORR) and has the potential to enable drug development. Its preclinical program, ACR-2316, is advancing in investigational new drug-enabling studies. It is a novel, dual WEE1 and PKMYT1 inhibitor small molecule development candidate.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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