AbbVie’s Venclyxto Receives Expanded Indication from EU
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 3 hours ago
0mins
AbbVie announced that the European Commission has authorized an expanded label for Venclyxto to include use in combination with acalabrutinib and use in combination with ibrutinib for the treatment of adult patients with previously untreated chronic lymphocytic leukemia. The expanded label follows the EC's inclusion of these combinations in the acalabrutinib and ibrutinib labels. These all-oral, fixed-duration combination regimens support current standards of care and offer patients and providers additional targeted oral medications for CLL in the first-line setting that include the potential for time off treatment. The European Commission authorization extends to all European Union Member States, as well as Iceland, Norway and Liechtenstein.
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Analyst Views on ABBV
Wall Street analysts forecast ABBV stock price to rise
18 Analyst Rating
12 Buy
6 Hold
0 Sell
Moderate Buy
Current: 218.630
Low
223.00
Averages
252.00
High
289.00
Current: 218.630
Low
223.00
Averages
252.00
High
289.00
About ABBV
AbbVie Inc. is a global, diversified, research-based biopharmaceutical company. It is engaged in research and development, manufacturing, commercialization and sale of medicines and therapies. Its product portfolio includes Immunology, Oncology, Aesthetics, Neuroscience, Eye Care and Other Key Products. Immunology products include rheumatology, dermatology and gastroenterology. Oncology products include Imbruvica, Venclexta/Venclyxto, Elahere and Epkinly. The aesthetics portfolio consists of facial injectables, plastics and regenerative medicine, body contouring, and skincare products. Its Neuroscience products include Botox Therapeutic, Vraylar, Duopa and Duodopa, Ubrelvy, and Qulipta. Duodopa is a levodopa-carbidopa intestinal gel for the treatment of Parkinson's disease. Eye care products include Ozurdex, Lumigan/Ganfort, Alphagan/Combigan, Restasis, and other eye care. Other key products include Mavyret/Maviret, Creon, and Linzess/Constella.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Clinical Trial Support: The combination of VENCLYXTO with acalabrutinib is supported by data from the AMPLIFY trial, while the combination with ibrutinib is backed by the GLOW and CAPTIVATE trials, demonstrating significant efficacy and safety advantages that further solidify AbbVie's leadership in oncology treatment.
- Diverse Treatment Options: The newly approved fixed-duration, chemotherapy-free VENCLYXTO combination regimens provide patients with additional treatment options that may offer potential treatment-free intervals, helping patients better manage their disease and improve quality of life, reflecting AbbVie's keen insight and responsiveness to patient needs.
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See More
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See More
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- Indication Expansion: AbbVie announced that the European Commission has approved an expanded label for VENCLYXTO to include its use in combination with acalabrutinib and ibrutinib for previously untreated chronic lymphocytic leukemia patients, enhancing its market competitiveness.
- Clinical Trial Support: The efficacy of VENCLYXTO in combination with acalabrutinib is supported by data from the Phase 3 AMPLIFY trial, which demonstrated a 35% reduction in the risk of disease progression or death compared to chemoimmunotherapy, showcasing significant clinical advantages.
- Survival Improvement: The combination of VENCLYXTO with ibrutinib is also backed by data from the Phase 3 GLOW and Phase 2 CAPTIVATE trials, which indicated clinically meaningful improvements in progression-free survival and overall survival at a 64-month follow-up.
- Market Impact: This authorization extends to all EU member states, as well as Iceland, Norway, and Liechtenstein, which is expected to drive ABBV's sales growth in the European market and further solidify its leadership position in blood cancer treatment.
See More
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- Indication Expansion: The European Commission has approved the use of VENCLYXTO in combination with acalabrutinib (with or without obinutuzumab) and ibrutinib for adult patients with previously untreated chronic lymphocytic leukemia (CLL), significantly broadening its application in first-line treatment.
- Clinical Trial Support: The combination of VENCLYXTO and acalabrutinib was shown to be superior to chemoimmunotherapy in the Phase 3 AMPLIFY trial, reducing the risk of disease progression or death by 35%, thus providing patients with a more effective treatment option.
- Patient Benefits: The introduction of these new combination regimens not only offers chemotherapy-free fixed-duration options but also has the potential for treatment-free intervals, significantly improving patients' quality of life and reducing treatment burdens.
- Market Impact: This approval allows VENCLYXTO to be available across all EU member states, as well as Iceland, Norway, and Liechtenstein, which is expected to drive AbbVie's sales growth in the European market and further solidify its leadership in the blood cancer treatment sector.
See More
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- Indication Expansion: The European Commission has authorized the use of VENCLYXTO in combination with acalabrutinib (with optional obinutuzumab) and ibrutinib for adult patients with previously untreated chronic lymphocytic leukemia (CLL), further solidifying AbbVie's leadership in hematologic cancer treatment.
- Clinical Trial Support: The combination of VENCLYXTO and acalabrutinib demonstrated superior efficacy over chemoimmunotherapy in the Phase 3 AMPLIFY trial, reducing the risk of disease progression or death by 35%, providing patients with a more effective treatment option.
- Patient Benefits: The new therapy's fixed-duration and chemotherapy-free nature offers the potential for treatment-free intervals, significantly improving patients' quality of life and meeting the evolving needs of patients and healthcare providers for flexible treatment options.
- Market Potential: With VENCLYXTO approved in over 80 countries, AbbVie enhances its competitive edge in the global market through this indication expansion, which is expected to drive future revenue growth for the company.
See More
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