Regeneron Reports Positive LINKER-AL2 Trial Results for Lynozyfic
Written by Emily J. Thompson, Senior Investment Analyst
Updated: May 21 2026
0mins
Source: Newsfilter
- Clinical Trial Results: In the LINKER-AL2 trial, Lynozyfic (linvoseltamab) achieved a nearly 100% hematologic complete response (CR) in patients with systemic AL amyloidosis who had received at least one prior therapy, demonstrating its remarkable efficacy compared to the standard-of-care.
- Organ Function Improvement: Despite the short follow-up, 73% of patients showed improved renal function and 50% showed improved cardiac function, indicating Lynozyfic's potential to enhance vital organ performance and provide new hope for patients facing life-threatening conditions.
- Safety Assessment: Among 20 patients treated, Lynozyfic exhibited no dose-limiting toxicities, although all experienced at least one treatment-emergent adverse event, with 65% being grade 3 or higher, highlighting the need for careful monitoring of safety profiles.
- Future Research Directions: The ongoing Phase 2 portion of the LINKER-AL2 trial aims to further validate the efficacy and safety of Lynozyfic, potentially offering new treatment options for patients with systemic AL amyloidosis who currently lack effective therapies.
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Analyst Views on REGN
Wall Street analysts forecast REGN stock price to rise
22 Analyst Rating
16 Buy
6 Hold
0 Sell
Moderate Buy
Current: 621.520
Low
637.00
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808.50
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1057
Current: 621.520
Low
637.00
Averages
808.50
High
1057
About REGN
Regeneron Pharmaceuticals, Inc. is a fully integrated biotechnology company. The Company invents, develops, manufactures, and commercializes medicines for people with serious diseases. Its products and product candidates in development are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neurological diseases, hematologic conditions, infectious diseases, and rare diseases. The Company is accelerating drug development using its proprietary technologies, such as VelociSuite, which produces optimized fully human antibodies and new classes of bispecific antibodies. VelociSuite consists of VelocImmune, VelociGene, VelociMouse, VelociMab, Veloci-Bi, VelociT, VelociHum, and other related technologies. Its marketed products include EYLEA (aflibercept); Dupixent (dupilumab); Libtayo (cemiplimab); Ordspono (odronextamab); Kevzara (sarilumab); Itepekimab; Lynozyfic, and others.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Emergency Response Coordination: Regeneron is closely coordinating with the U.S. Department of Health and Human Services to prepare for clinical trials in the Democratic Republic of the Congo and Uganda, aiming to respond swiftly to WHO's declaration of the current Ebola outbreak as a public health emergency.
- Historical Contributions: Since 2018, Regeneron has provided Inmazeb to infected individuals under a compassionate use protocol, showcasing its rapid response capabilities during global health crises and solidifying its leadership in infectious disease treatment.
- Donations and Stockpiles: In September 2025, Regeneron donated 500 doses of Inmazeb to the WHO for exclusive use in low-income countries, enhancing global preparedness for Ebola outbreaks while also supplying stockpiles to the U.S. government to bolster national public health emergency readiness.
See More
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- Patient Usage: Hundreds of patients have already received Maftivimab as part of Inmazeb, which has demonstrated an acceptable safety profile, indicating its potential in combating Ebola outbreaks.
- Company Coordination Efforts: Regeneron is closely coordinating with the U.S. Department of Health and Human Services and WHO as clinical evaluations progress, emphasizing its history of rapidly delivering medical solutions during global health crises, thereby enhancing its reputation in public health.
See More
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- Vaccine Usage Restrictions: Merck's Ervebo is the only licensed Ebola vaccine; however, WHO emphasizes that it should only be used in carefully designed research settings to assess its effectiveness against Bundibugyo ebolavirus, ensuring safety and efficacy.
See More
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- Legal Action Possibility: Investors who purchased Commvault shares between April 29, 2025, and January 26, 2026, may participate in the class action lawsuit, seeking legal remedies and corporate governance reforms.
- Significant Stock Impact: Following Regeneron's Phase 3 trial results failing to achieve statistical significance, its stock dropped 9.82% on May 16, 2026, indicating market concerns over the company's future prospects, which could affect its financing capabilities and investor confidence.
See More
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- Innovative Focus: The partnership will concentrate on developing the Helicon peptide platform, aiming to create therapies that can act as standalone treatments or components of antibody-Helicon conjugates targeting previously 'undruggable' intracellular proteins, which holds significant market potential.
- Milestone Payment Structure: Under the agreement, Parabilis is eligible for up to $2.2 billion in milestone payments and tiered royalties, which not only incentivizes collaborative R&D but also provides substantial future revenue potential for Parabilis.
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