Oppenheimer Reaffirms Outperform Rating for Xeris Biopharma Holdings (XERS)
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Oct 31 2025
0mins
Should l Buy XERS?
Source: NASDAQ.COM
Analyst Coverage: Oppenheimer has maintained an "Outperform" rating for Xeris Biopharma Holdings (NasdaqGS:XERS) as of October 29, 2025, with an average one-year price target of $9.18/share, indicating a potential downside of 5.51% from its recent closing price.
Fund Sentiment: There has been an increase in institutional ownership of Xeris Biopharma, with 361 funds reporting positions, reflecting a 6.18% rise in the last quarter and a total of 104,118K shares owned by institutions.
Shareholder Activity: Notable shareholders like Vanguard and D. E. Shaw have adjusted their holdings, with Vanguard increasing its shares by 16.61% while D. E. Shaw raised its stake by 20.42%, despite both firms reducing their overall portfolio allocation in XERS.
Market Outlook: The put/call ratio for XERS stands at 0.12, suggesting a bullish sentiment among investors, while the projected annual revenue is expected to decrease slightly by 0.64%.
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Analyst Views on XERS
Wall Street analysts forecast XERS stock price to rise
4 Analyst Rating
4 Buy
0 Hold
0 Sell
Strong Buy
Current: 6.910
Low
9.00
Averages
9.67
High
10.00
Current: 6.910
Low
9.00
Averages
9.67
High
10.00
About XERS
Xeris Biopharma Holdings, Inc. is a biopharmaceutical company focused on improving patient lives by developing and commercializing products across a range of therapies. It has three commercially available products: Recorlev, Gvoke, and Keveyis. Recorlev is for the treatment of endogenous Cushing’s syndrome. Gvoke is a ready-to-use liquid glucagon for the treatment of severe hypoglycemia. Keveyis is a therapy for primary periodic paralysis. It also has a pipeline of development programs led by XP-8121, a phase III-ready, once-weekly subcutaneous injection for hypothyroidism. It is pursuing formulation and development partnerships to apply its XeriSol and XeriJect formulation technologies to enhance the drug delivery and clinical profile of other companies’ proprietary drugs and biologics. Recorlev is a cortisol synthesis inhibitor approved for the treatment of endogenous hypercortisolemia in adults with Cushing's syndrome for whom surgery is not an option or has not been curative.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Product Performance: Recorlev® achieved net revenue of $45 million in Q4 2025 and $139 million for the full year, demonstrating increasing market acceptance in treating endogenous Cushing's syndrome.
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- Revenue Growth: Xeris anticipates total revenue of $292 million for 2025, exceeding the guidance range of $285-$290 million and reflecting a 44% increase from the previous year, indicating strong market demand and product performance.
- Product Performance: Recorlev® achieved net revenue of $45 million in Q4 2025 and $139 million for the full year, demonstrating increasing market acceptance in treating endogenous Cushing's syndrome.
- Patient Base Expansion: By the end of 2025, approximately 700 patients were on Recorlev® therapy, while Gvoke® saw revenue growth of over 13% year-over-year, showcasing the company's success in patient treatment and market penetration.
- Financial Stability: Xeris delivered positive adjusted EBITDA in every quarter, reinforcing the company's financial foundation and positioning it for sustained growth in the future.
See More
Outlook Therapeutics Inc Faces 60.9% Drop After FDA Response on ONS-5010
- FDA Rejection: Outlook Therapeutics Inc's resubmission for the ONS-5010 biologics license application received a complete response letter from the FDA, indicating that the application cannot be approved in its current form, leading to a 60.9% drop in pre-market trading to $0.62, severely impacting investor confidence.
- Severe Market Reaction: The significant decline in Outlook Therapeutics' stock price reflects market concerns over its future product development prospects, which may hinder financing efforts and delay research progress.
- Other Stock Movements: In pre-market trading, Intelligent Bio Solutions Inc's stock fell 19.2% to $7.70 following the announcement of a $10 million private placement, indicating a decreased risk appetite among investors in the biotech sector.
- Overall Market Trend: While Nasdaq 100 futures rose about 1%, several stocks showed weakness in pre-market trading, suggesting that investor sentiment in the biotech sector is shaken, which could affect overall market mood.
See More
Xeris Biopharma Shares Surge 7.59% as Competitor Corcept's FDA Approval Fails
- Stock Surge: Xeris Biopharma's shares rose 7.59% on Wednesday following the news that competitor Corcept Therapeutics' drug failed to gain FDA approval, reflecting investor confidence in Xeris's existing medication, Recorlev, which is expected to further solidify its market position.
- Market Potential: Analyst Glen Santangelo reiterated a buy rating on Xeris with a $10 price target, highlighting that the addressable market for Cushing's disease could grow from the current $1 billion to $3 billion by 2030, indicating significant growth potential for Xeris in this sector.
- FDA Decision Impact: Corcept's relacorilant was not approved by the FDA due to insufficient evidence of effectiveness, a decision that will reduce competition for Xeris's Recorlev, thereby enhancing its sales outlook.
- Clinical Trial Challenges: Although Corcept has vowed to continue pursuing approval, this will likely require additional clinical trials, potentially delaying its market entry and providing Xeris with more time and space to expand its market share.
See More
Xeris Biopharma Gains 7% as Corcept's FDA Setback Boosts Investor Sentiment
- Stock Surge: Xeris Biopharma's stock rose over 7% on Wednesday as investors reacted positively to the news that competitor Corcept Therapeutics' drug was not approved by the FDA, reflecting optimism about Xeris's market prospects.
- Market Opportunity: Analyst Glen Santangelo reiterated a buy rating on Xeris with a $10 price target, forecasting that the addressable market for Cushing's disease could grow from $1 billion to $3 billion by 2030, positioning Xeris to benefit significantly.
- FDA Response: Corcept's complete response letter from the FDA cited a lack of additional evidence for the drug's effectiveness as the main reason for the rejection, allowing Xeris's Recorlev to maintain its market dominance.
- Clinical Trial Challenges: Although Corcept has vowed to continue seeking approval, this will likely require more clinical trials, which could diminish its competitive edge, further solidifying Xeris's position in the market.
See More
Xeris Biopharma (XERS) Drops 9.3% Following XP-8121 Patent Milestone Announcement – Is the Bullish Outlook Still Valid?
Patent Milestone: Xeris Biopharma Holdings received a Notice of Allowance from the USPTO for its patent application on XP-8121, a once-weekly, subcutaneous levothyroxine formulation, enhancing its intellectual property protection in the levothyroxine market.
Investment Outlook: The patent approval is seen as a positive long-term catalyst for Xeris, potentially reducing reliance on existing products, but investors should remain cautious about the company's current dependence on its commercial drugs and the risks associated with rising R&D and SG&A costs.
Revenue Projections: Xeris is projected to achieve $440.9 million in revenue and $84.8 million in earnings by 2028, necessitating significant annual growth, while current valuations among analysts vary widely, indicating differing expectations for the company's future performance.
Research and Analysis: Simply Wall St offers a comprehensive analysis of Xeris Biopharma, highlighting key rewards and risks, and emphasizes the importance of evaluating the company's financial health and market position before making investment decisions.
See More
