Neurocrine Reports New INGREZZA Data for Tardive Dyskinesia
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jun 08 2026
0mins
Source: PRnewswire
- Clinical Data Highlights: Neurocrine Biosciences presented new data at a conference in Dallas showing that INGREZZA (valbenazine) significantly improves tardive dyskinesia (TD) severity in patients with intellectual and developmental disabilities, with 89% of patients demonstrating symptom improvement within four weeks, indicating the drug's potential to enhance quality of life.
- Functional Status Improvement: The study revealed that 96% of patients treated with INGREZZA experienced improvements in overall functional status, with 90% negatively impacted by TD symptoms at baseline, showcasing significant enhancements in independence and social skills post-treatment, reflecting the drug's importance in daily life.
- Patient Population Characteristics: The analysis was based on clinician-reported data from 30 patients with intellectual and developmental disabilities, averaging 47.3 years old, with 70% diagnosed with schizophrenia, highlighting the high risk and treatment needs of this population for TD.
- Research Commitment: Neurocrine emphasizes its ongoing commitment to advancing studies that better represent and serve diverse populations affected by TD, underscoring INGREZZA's potential in improving patient functionality and emotional health, further promoting awareness and treatment of the condition.
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Analyst Views on NBIX
Wall Street analysts forecast NBIX stock price to rise
20 Analyst Rating
17 Buy
3 Hold
0 Sell
Strong Buy
Current: 159.000
Low
143.00
Averages
179.68
High
203.00
Current: 159.000
Low
143.00
Averages
179.68
High
203.00
About NBIX
Neurocrine Biosciences, Inc. is a neuroscience-focused, biopharmaceutical company. It is engaged in discovering, developing, and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine, and immunological disorders. Its diverse portfolio includes the United States Food and Drug Administration-approved treatments for tardive dyskinesia, chorea associated with Huntington’s disease, endometriosis and uterine fibroids, as well as a robust pipeline, including multiple compounds in mid-to late-phase clinical development across its core therapeutic areas. Its first-in-class commercial portfolio includes INGREZZA (valbenazine) and CRENESSITY (crinecerfont). It also offers VYKAT XR (diazoxide choline) extended-release tablets, for the treatment of hyperphagia in adults and pediatric patients four years of age and older with Prader-Willi syndrome (PWS). Its pipeline includes direclidine / (M4 Agonist), osavampator॥ / (AMPA PAM) and others.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Clinical Trial Data: Results from Study C614 involving 77 participants indicated that those who resumed treatment experienced significant recovery in hyperphagia symptoms, while those on continuous therapy maintained notable improvements in hyperphagia and other PWS-related behaviors.
- Long-Term Follow-Up Study: Compared to 229 natural history controls, VYKAT XR demonstrated statistically significant improvements in hyperphagia scores at all evaluated time points over three years, highlighting the drug's sustained efficacy.
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See More
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- Clinical Findings: Neurocrine Biosciences announced results from a retrospective case series involving 15 patients with classic congenital adrenal hyperplasia (CAH) due to 11β-hydroxylase deficiency, demonstrating that treatment with CRENESSITY® (crinecerfont) led to significant reductions in androgen precursors and improved blood pressure, indicating the drug's potential in managing this rare CAH subtype.
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- Clinical Significance: This case series provides critical clinical insights for managing patients with 11β-hydroxylase deficiency, aiding clinicians in treatment decisions amidst limited data, thus addressing a complex subgroup within classic CAH.
- Future Research Directions: Neurocrine emphasized its commitment to further exploring the application of CRENESSITY in classic CAH subtypes, reinforcing its dedication to advancing treatment options for patients with rare endocrine disorders.
See More
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- Improved Medication Adherence: Among the 15 patients treated with CRENESSITY, 14 were able to reduce their total glucocorticoid dose, indicating the drug's effectiveness in reducing hormone dependency.
- Blood Pressure Improvement: Among patients receiving antihypertensive treatment, two were able to reduce or discontinue these medications, suggesting CRENESSITY's potential benefits in managing hypertension.
- Clinical Research Breakthrough: This retrospective case series provides initial clinical insights for patients with 11β-hydroxylase deficiency, highlighting the importance of CRENESSITY in treating classic congenital adrenal hyperplasia and promoting further research into this rare subtype.
See More
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- Clinical Trial Data Support: Three-year data for VYKAT XR showed statistically significant improvements in hyperphagia scores compared to controls from the natural history study, with treatment differences of 6.2, 6.5, and 6.2 points at Year 1, Year 2, and Year 3, respectively, highlighting the drug's sustained effectiveness.
- Comprehensive Behavioral Improvements: Participants who resumed VYKAT XR exhibited significant improvements across all six behavioral domains of PWS over two years, particularly in anxiety, compulsivity, and aggression, further validating the multidimensional efficacy of the drug.
- Ongoing Safety Monitoring: Throughout the clinical trials, long-term use of VYKAT XR did not result in severe adverse reactions, and participants' body mass index (BMI) remained relatively stable, demonstrating the drug's ability to effectively manage overall health while treating hyperphagia.
See More
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- Bone Age and Height Improvement: Among 41 growing patients, 24 with advanced bone age at baseline showed stable or improved bone age scores after 24 months, with a mean decrease of 1.12 standard deviations, while nine patients had reductions greater than two standard deviations, alongside a mean increase of 4.7 cm in predicted adult height, highlighting Crenessity's significant impact.
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