INGREZZA Shows Rapid Improvement in Tardive Dyskinesia for Patients with Intellectual Disabilities
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jun 08 2026
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Source: Newsfilter
- Clinical Data Highlights: Nearly all patients with intellectual and developmental disabilities treated with INGREZZA experienced improvement in tardive dyskinesia severity, with 89% (25/28) showing significant improvement within four weeks of treatment initiation, indicating the drug's short-term efficacy in alleviating symptoms and enhancing quality of life.
- Functional Status Improvement: Clinicians reported that 96% of patients experienced improvements in overall functional status post-treatment, particularly in key areas of daily living such as socializing, emotional well-being, and motor skills, showcasing INGREZZA's potential to enhance overall quality of life for patients.
- Patient Population Characteristics: The analysis was based on data from patients who initiated INGREZZA treatment between January and June 2024, involving 30 individuals with intellectual and developmental disabilities, with a mean age of 47.3 years, and 70% having psychiatric comorbidities, emphasizing the drug's significance in this specific population.
- Long-term Commitment: Neurocrine Biosciences' Chief Medical Officer noted that the clinical improvement results complement patient-reported outcomes from the KINECT-PRO study, reflecting the company's commitment to advancing treatment options for diverse populations affected by tardive dyskinesia.
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Analyst Views on NBIX
Wall Street analysts forecast NBIX stock price to rise
20 Analyst Rating
17 Buy
3 Hold
0 Sell
Strong Buy
Current: 159.000
Low
143.00
Averages
179.68
High
203.00
Current: 159.000
Low
143.00
Averages
179.68
High
203.00
About NBIX
Neurocrine Biosciences, Inc. is a neuroscience-focused, biopharmaceutical company. It is engaged in discovering, developing, and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine, and immunological disorders. Its diverse portfolio includes the United States Food and Drug Administration-approved treatments for tardive dyskinesia, chorea associated with Huntington’s disease, endometriosis and uterine fibroids, as well as a robust pipeline, including multiple compounds in mid-to late-phase clinical development across its core therapeutic areas. Its first-in-class commercial portfolio includes INGREZZA (valbenazine) and CRENESSITY (crinecerfont). It also offers VYKAT XR (diazoxide choline) extended-release tablets, for the treatment of hyperphagia in adults and pediatric patients four years of age and older with Prader-Willi syndrome (PWS). Its pipeline includes direclidine / (M4 Agonist), osavampator॥ / (AMPA PAM) and others.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Clinical Trial Data: Results from Study C614 involving 77 participants indicated that those who resumed treatment experienced significant recovery in hyperphagia symptoms, while those on continuous therapy maintained notable improvements in hyperphagia and other PWS-related behaviors.
- Long-Term Follow-Up Study: Compared to 229 natural history controls, VYKAT XR demonstrated statistically significant improvements in hyperphagia scores at all evaluated time points over three years, highlighting the drug's sustained efficacy.
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See More
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- Clinical Significance: This case series provides critical clinical insights for managing patients with 11β-hydroxylase deficiency, aiding clinicians in treatment decisions amidst limited data, thus addressing a complex subgroup within classic CAH.
- Future Research Directions: Neurocrine emphasized its commitment to further exploring the application of CRENESSITY in classic CAH subtypes, reinforcing its dedication to advancing treatment options for patients with rare endocrine disorders.
See More
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- Improved Medication Adherence: Among the 15 patients treated with CRENESSITY, 14 were able to reduce their total glucocorticoid dose, indicating the drug's effectiveness in reducing hormone dependency.
- Blood Pressure Improvement: Among patients receiving antihypertensive treatment, two were able to reduce or discontinue these medications, suggesting CRENESSITY's potential benefits in managing hypertension.
- Clinical Research Breakthrough: This retrospective case series provides initial clinical insights for patients with 11β-hydroxylase deficiency, highlighting the importance of CRENESSITY in treating classic congenital adrenal hyperplasia and promoting further research into this rare subtype.
See More
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- Significant Treatment Effects: Participants who resumed VYKAT XR after a 16-week randomized withdrawal period demonstrated marked improvements in hyperphagia and behavioral symptoms as early as Week 13, with benefits sustained over two years, indicating the drug's long-term efficacy in Prader-Willi syndrome (PWS) patients.
- Clinical Trial Data Support: Three-year data for VYKAT XR showed statistically significant improvements in hyperphagia scores compared to controls from the natural history study, with treatment differences of 6.2, 6.5, and 6.2 points at Year 1, Year 2, and Year 3, respectively, highlighting the drug's sustained effectiveness.
- Comprehensive Behavioral Improvements: Participants who resumed VYKAT XR exhibited significant improvements across all six behavioral domains of PWS over two years, particularly in anxiety, compulsivity, and aggression, further validating the multidimensional efficacy of the drug.
- Ongoing Safety Monitoring: Throughout the clinical trials, long-term use of VYKAT XR did not result in severe adverse reactions, and participants' body mass index (BMI) remained relatively stable, demonstrating the drug's ability to effectively manage overall health while treating hyperphagia.
See More
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- Bone Age and Height Improvement: Among 41 growing patients, 24 with advanced bone age at baseline showed stable or improved bone age scores after 24 months, with a mean decrease of 1.12 standard deviations, while nine patients had reductions greater than two standard deviations, alongside a mean increase of 4.7 cm in predicted adult height, highlighting Crenessity's significant impact.
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