Fennec Pharmaceuticals Confirms Full Debt Redemption Completion
Debt Redemption: Fennec Pharmaceuticals has repurchased and redeemed all outstanding convertible notes from Petrichor Opportunities Fund, totaling approximately $21.7 million, using proceeds from a recent public offering, leaving the company with no outstanding debt.
Product Focus: The company is dedicated to combating ototoxicity in cancer patients undergoing cisplatin-based chemotherapy, primarily through its FDA-approved product, PEDMARK®, which is now commercially available in several regions.
Licensing Agreement: Fennec has entered into an exclusive licensing agreement with Norgine Pharmaceuticals for the commercialization of PEDMARQSI® in Europe, the U.K., Australia, and New Zealand, expanding its market reach.
Regulatory Approvals: PEDMARK® has received Orphan Drug Exclusivity in the U.S. and PEDMARQSI® has been granted Pediatric Use Marketing Authorization in Europe, ensuring significant market protection and exclusivity for the products.
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- Share Disposition: On December 24, 2025, Southpoint Capital Advisors disposed of 1 million common shares of Fennec Pharmaceuticals at $7.50 per share, reducing its ownership stake to approximately 8% of the outstanding shares.
- Market Strategy: This sale indicates a strategic adjustment in Southpoint's investment portfolio, as it still controls 2.7 million shares, but the reduced stake may reflect a cautious outlook on market conditions.
- Compliance Disclosure: The press release serves to comply with securities regulations, ensuring transparency and maintaining market trust, highlighting Southpoint's commitment to regulatory adherence.
- Future Outlook: Depending on market and other conditions, Southpoint may further adjust its ownership of Fennec through market transactions or other means, indicating flexibility in its investment strategy.
- Share Disposition: On December 24, 2025, Southpoint Capital Advisors disposed of 1 million common shares of Fennec Pharmaceuticals at $7.50 per share, reducing its ownership stake to approximately 8% of the total outstanding shares.
- Market Strategy: The shares sold represent about 2.93% of Fennec's total outstanding shares, indicating Southpoint's flexible investment strategy in response to changing market conditions, which could impact Fennec's stock performance.
- Ownership Adjustment: Following this transaction, Southpoint retains control over 2.7 million shares of Fennec, reflecting ongoing interest in the company, although the reduction may suggest a response to short-term market volatility.
- Future Outlook: Southpoint indicated that it may further adjust its ownership of Fennec based on market and other conditions, demonstrating its proactive and flexible approach to investment management.
- Share Disposal: On December 24, 2025, Southpoint Capital Advisors disposed of 1 million common shares of Fennec Pharmaceuticals at $7.50 per share, reducing its stake to approximately 8%, indicating a potential shift in its investment strategy regarding the company.
- Market Impact: This transaction decreases Southpoint's control to 2.7 million shares, representing about 8% of the outstanding shares, reflecting its strategy to adjust its portfolio in response to changing market conditions for optimized returns.
- Investment Purpose: The share disposal was executed for investment purposes, suggesting Southpoint's intent to seek higher returns while maintaining flexibility to respond to market dynamics.
- Future Outlook: Depending on market and other conditions, Southpoint may further adjust its ownership of Fennec through market transactions, private agreements, or other means, demonstrating its adaptability and strategic flexibility in a dynamic market environment.

- Study Initiation: Fennec Pharmaceuticals announced an investigator-sponsored study by City of Hope to evaluate PEDMARK® for preventing ototoxicity in adult men with stage II-III metastatic testicular germ cell tumors, reflecting growing clinical interest in addressing chemotherapy-induced hearing loss.
- Clinical Need: Research indicates that 60-90% of patients treated with cisplatin may experience hearing loss, and the application of PEDMARK® could significantly enhance the quality of life for these patients, addressing an increasing clinical demand.
- Market Potential: Approximately 500,000 patients in the U.S. are diagnosed annually with cancers treatable by cisplatin, and the FDA approval of PEDMARK® opens new market opportunities for its use in adult patients, which is expected to drive future commercial growth for the company.
- Strategic Collaborations: Fennec is collaborating with multiple research institutions to advance studies on PEDMARK® in metastatic diseases, aiming to expand its clinical evidence base and enhance its competitive position in the market.

Study Results: Fennec Pharmaceuticals announced positive topline results from the Phase 2/3 STS-J01 trial of Pedmark, showing reduced rates of cisplatin-induced ototoxicity in pediatric patients, with only 24% and 16% experiencing hearing loss compared to higher rates in previous trials.
Safety and Efficacy: The study confirmed that Pedmark does not interfere with the antitumor activity of cisplatin, maintaining a high tumor response rate of approximately 95%, and was well-tolerated with no adverse events attributed to the drug.
Future Plans: Fennec intends to pursue regulatory registration for Pedmark in Japan and explore potential partnerships or licensing opportunities, with full study results to be presented in a scientific forum and submitted for publication.
Market Reaction: Following the announcement, Fennec Pharmaceuticals' stock experienced a slight decline of 0.78%, trading at $7.85.







