Boston Scientific's SEISMIQ 4CE Catheter Clinical Trial Achieves Success
Written by Emily J. Thompson, Senior Investment Analyst
Updated: May 19 2026
0mins
Source: seekingalpha
- Clinical Trial Success: Boston Scientific's SEISMIQ 4CE catheter successfully met primary safety and effectiveness endpoints in the FRACTURE trial involving 420 patients with severely calcified coronary artery disease, highlighting its potential in cardiovascular treatment.
- Outstanding Safety Metrics: The trial demonstrated a nearly 93% freedom rate from major adverse cardiac events (MACE) at 30 days, significantly exceeding the company's target of 86%, thereby establishing a solid foundation for market introduction.
- Impressive Effectiveness: The SEISMIQ 4CE catheter achieved a procedural success rate of approximately 94%, successfully delivering stents with no in-hospital MACE, further validating its reliability in clinical applications.
- Regulatory Submission Support: Boston Scientific's Chief Medical Officer noted that the data presented today serves as pivotal evidence to support the regulatory submission for the SEISMIQ 4CE catheter, indicating a promising market outlook for the product.
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Analyst Views on BSX
Wall Street analysts forecast BSX stock price to rise
22 Analyst Rating
22 Buy
0 Hold
0 Sell
Strong Buy
Current: 49.110
Low
94.00
Averages
108.14
High
132.00
Current: 49.110
Low
94.00
Averages
108.14
High
132.00
About BSX
Boston Scientific Corporation is a global developer, manufacturer and marketer of medical devices that are used in a range of interventional medical specialties. The Company's MedSurg segment includes Endoscopy, Urology, and Neuromodulation. Its Endoscopy business develops and manufactures devices to diagnose and treat a range of gastrointestinal conditions with less-invasive technologies. Its Urology business develops and manufactures devices to treat various urological conditions for both male and female anatomies, including kidney stones, benign prostatic hyperplasia, prostate cancer, erectile dysfunction, and incontinence. Its Neuromodulation business develops and manufactures devices to treat various neurological movement disorders and manage chronic pain. Its Cardiovascular segment includes Cardiology and Peripheral Interventions. The Cardiology includes interventional cardiology and vascular therapies (ICVT), watchman, cardiac rhythm management, and electrophysiology.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Market Share Challenges: CEO Michael Mahoney confirmed at an investor conference that standalone WATCHMAN growth remains a challenge, despite the company holding a 90%-91% market share in that area, indicating that the slowdown poses a significant threat to business performance.
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See More
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See More
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- Lowered Growth Outlook: During its Q1 2026 earnings release, the company revised its full-year organic net sales growth forecast down to 6.5%-8.0%, largely attributed to headwinds in WATCHMAN volumes and its electrophysiology business in the U.S.
- Market Share Challenges: CEO Michael Mahoney confirmed at an investor conference that standalone WATCHMAN growth remains a challenge, despite the company holding a 90%-91% market share in that area, indicating that the slowdown poses a significant threat to business performance.
- Confidence in Future Investments: Despite facing short-term challenges, Mahoney reiterated the company's comfort with its guidance ranges for the second quarter and the full year, emphasizing ongoing investments across its businesses to support future growth.
See More
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- Acquisition Potential: This investment not only grants Boston Scientific immediate ownership of one-third of MiRus but also lays the groundwork for a potential 100% acquisition, allowing for an additional $3 billion payment if MiRus's TAVR system meets specific milestones, thereby mitigating investment risks.
- Insider Buying Signal: While 92% of analysts rate Boston Scientific as a buy, the recent purchase of over $500,000 in shares by three directors indicates strong insider confidence in the company's future, further bolstering market sentiment towards the stock.
- Buyback Plan and Growth Outlook: Boston Scientific has also announced a $2 billion accelerated buyback program, signaling management's favorable view of the stock's valuation, while analysts project earnings growth of over 16% annually over the next three to five years, making the current stock price appear attractive.
See More
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- Analyst Downgrades: Wells Fargo analyst Lawrence Biegelsen downgraded Boston Scientific's rating from overweight to equal weight and reduced the price target from $75 to $55, indicating a pessimistic outlook on the company's future performance.
- Revenue Growth Guidance: Despite facing challenges, Boston Scientific maintained its guidance for organic revenue growth of 6.5% to 8% for 2026, demonstrating confidence in long-term growth potential.
- Increased Market Competition: Analysts noted that new drugs under development by pharmaceutical companies could heighten competitive pressure, particularly in other product categories like urology, further impacting the company's market position.
See More
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- Analyst Downgrades: Amid increasing pessimism, Wells Fargo analyst Lawrence Biegelsen downgraded the stock from overweight to equal weight and reduced the price target from $75 to $55, highlighting concerns over the new Watchman forecast and weakness in other product lines, such as urology.
- Significant Market Reaction: As of early Friday morning, Boston Scientific's shares had dropped by 15%, reflecting investor concerns about the company's future growth potential, particularly in the face of increasing competition that could affect its market share.
- Positive Long-Term Outlook: Despite short-term challenges, Boston Scientific maintained its guidance for organic revenue growth of 6.5% to 8% for 2026, indicating the company's long-term potential in the medical device sector, suggesting that investors may view this week's stock decline as an opportunity to acquire quality shares at a discount in a vibrant industry.
See More
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- Boston Scientific's Decline: CEO Michael Mahoney indicated that standalone Watchman procedures are weakening, leading to a 12% stock drop on Wednesday, hitting a two-year low of $50.04, which underscores the growth pressures in the medical device market.
- Li Auto's Loss Expectations: Li Auto's stock reached a 52-week low of $15.3 ahead of its earnings report, with analysts forecasting a RMB2.08 ($0.31) per-share loss, highlighting the intensified competition and price declines in China's EV market impacting profitability.
- BJ's Wholesale Earnings Outlook: BJ's Wholesale Club faced selling pressure as investors questioned its near-term earnings, with a 10-basis-point decline in merchandise margins in Q1, prompting DA Davidson to lower its price target to $105 while maintaining a 'Buy' rating, indicating challenges in the retail sector.
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See More
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- Challenges for WATCHMAN: Although the WATCHMAN device remains the market share leader in its niche, its slowdown in growth has diminished investor confidence in future sales, particularly with muted expectations for Q2 and Q3.
- Industry Pressure: Peers like Abbott and Stryker also faced declines of 1.14% and 2.24%, respectively, reflecting broader pressures across the medical device sector, prompting investors to reassess the market environment.
See More
