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MAZE Should I Buy

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Intellectia

Should You Buy Maze Therapeutics Inc (MAZE) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Hold
Latest Price
28.710
1 Day change
-1.17%
52 Week Range
53.650
Analysis Updated At
2026/04/03
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Maze Therapeutics Inc (MAZE) is not a strong buy at the moment for a beginner investor with a long-term strategy. While the company has promising drug candidates and positive analyst sentiment, the technical indicators suggest a bearish trend, and the financials are weak with no revenue and significant losses. The lack of recent trading signals and congress trading data further supports a cautious approach.

Technical Analysis

The MACD histogram is negative (-2.128) and contracting, indicating a bearish trend. RSI is at 14.259, signaling the stock is oversold. Moving averages are converging, showing no clear trend. Key support level is at 29.444, and the stock is trading near this level at 28.51, suggesting potential downside risk.

Options Data

Bullish
Open Interest Put-Call Ratio
Neutral
Option Volume Put-Call Ratio

Technical Summary

StrongSellSellNeutralBuyStrongBuydotted line Image
Sell
8
Buy
7

Positive Catalysts

  • The company's pipeline is considered differentiated and competitive, with potential for high revenue generation.

Neutral/Negative Catalysts

  • Technical indicators are bearish, and there is no recent congress trading data or strong trading signals to support a buy.

Financial Performance

In Q4 2025, the company reported no revenue growth (0% YoY) and a net income loss of -$34.57M, albeit an improvement of 604.61% YoY. EPS improved to -0.65 (up 490.91% YoY), but gross margin dropped to 0, indicating no profitability.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

Analyst sentiment is positive, with firms like JPMorgan, Raymond James, and H.C. Wainwright raising price targets significantly and maintaining strong buy or overweight ratings. The target prices range from $46 to $110, reflecting high expectations for the company's drug pipeline.

Wall Street analysts forecast MAZE stock price to rise
8 Analyst Rating
Wall Street analysts forecast MAZE stock price to rise
8 Buy
0 Hold
0 Sell
Strong Buy
Current: 29.050
sliders
Low
46
Averages
52
High
60
Current: 29.050
sliders
Low
46
Averages
52
High
60
JPMorgan
NULL
to
Overweight
maintain
$52 -> $58
AI Analysis
2026-03-31
New
Reason
JPMorgan
Price Target
$52 -> $58
AI Analysis
2026-03-31
New
maintain
NULL
to
Overweight
Reason
JPMorgan raised the firm's price target on Maze Therapeutics to $58 from $52 and keeps an Overweight rating on the shares. The firm cites an increased probability of success for MZE829 post the Phase 2 data for the target bump. MZE829 looks "directionally better" in the focal segmental glomerulosclerosis population, the analyst tells investors in a research note.
Raymond James
Strong Buy
maintain
$56
2026-03-25
Reason
Raymond James
Price Target
$56
2026-03-25
maintain
Strong Buy
Reason
Raymond James reiterates a Strong Buy rating and $56 price target on Maze Therapeutics (MAZE) after the company announced data from the ongoing Phase 2 HORIZON study of MZE829 in AMKD. Early proteinuria data showing that MZE829 achieved a 61.8% reduction at Week 12 in four focal segmental glomerulosclerosis patients, comparing favorably to proof-of-concept data for Vertex Pharmaceuticals's (VRTX) inaxaplin and supporting competitiveness and a potential best-in-class profile in FSGS. Results in broader AMKD populations were more variable, with some greater than 30% responders across diabetic and non-diabetic patients, offering incremental mechanistic validation but limited de-risking beyond FSGS pending larger datasets and future HORIZON updates. The firm says the sell-off on the HORIZON study update looks like an overreaction.
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