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ALXO Should I Buy

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Intellectia

Should You Buy ALX Oncology Holdings Inc (ALXO) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Hold
Latest Price
1.910
1 Day change
-6.37%
52 Week Range
2.660
Analysis Updated At
2026/03/26
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ALX Oncology Holdings Inc (ALXO) is not a strong buy for a beginner investor with a long-term focus and $50,000-$100,000 to invest. The stock lacks immediate positive catalysts, exhibits weak technical indicators, and has poor financial performance. Insider selling and no recent congress trading data further detract from its attractiveness. While analysts have optimistic long-term price targets, the lack of near-term growth and significant risks make it better to hold off on investing at this time.

Technical Analysis

The MACD is negatively expanding, RSI is neutral at 36.923, and moving averages are converging, indicating no clear trend. The stock is trading near its support level of 1.987, with resistance at 2.231. Overall, the technical indicators suggest a weak or uncertain trend.

Options Data

Bullish
Open Interest Put-Call Ratio
Bullish
Option Volume Put-Call Ratio

Technical Summary

StrongSellSellNeutralBuyStrongBuydotted line Image
Sell
7
Buy
5

Positive Catalysts

  • and see potential in ALX Oncology's CD47 combo program for metastatic breast cancer, which could deliver results in mid-2027.

Neutral/Negative Catalysts

  • Insider selling has increased by 2135% over the last month, and there are no significant hedge fund trading trends. Financial performance is weak, with a net income drop of -21.65% YoY and an EPS decline of -22.22% YoY. No recent news or congress trading data is available.

Financial Performance

In 2025/Q4, revenue remained at $0 with no growth YoY. Net income dropped to -$22.85M (-21.65% YoY), and EPS fell to -0.42 (-22.22% YoY). Gross margin remained at 0 with no improvement.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

Analysts have given Buy or Overweight ratings with price targets ranging from $4 to $6. They are optimistic about the company's CD47 combo program and its potential to deliver strong results in mid-2027. However, the next major catalyst is not expected until the second half of 2026.

Wall Street analysts forecast ALXO stock price to rise
4 Analyst Rating
Wall Street analysts forecast ALXO stock price to rise
3 Buy
1 Hold
0 Sell
Strong Buy
Current: 2.040
sliders
Low
2
Averages
3.33
High
4
Current: 2.040
sliders
Low
2
Averages
3.33
High
4
Wells Fargo
Overweight
initiated
$5
AI Analysis
2026-03-19
Reason
Wells Fargo
Price Target
$5
AI Analysis
2026-03-19
initiated
Overweight
Reason
Wells Fargo initiated coverage of ALX Oncology with an Overweight rating and $5 price target. The firm thinks the near-term update for the evorpacept plus zanidatamab combo in metastatic breast cancer will further validate ALX's CD47-high enrichment strategy. Wells says the update will de-risk the ASPEN-Breast readout in mid-2027. It likes the setup for ALX shares.
H.C. Wainwright
Swayampakula Ramakanth
maintain
$2 -> $4
2026-03-10
Reason
H.C. Wainwright
Swayampakula Ramakanth
Price Target
$2 -> $4
2026-03-10
maintain
Reason
H.C. Wainwright analyst Swayampakula Ramakanth raised the firm's price target on ALX Oncology to $4 from $2 and keeps a Buy rating on the shares. The firm says the next major catalyst for the shares is the ALX2004 safety data in the second half of 2026. There is potential for ALX2004 to be different from other EGFR antibody-drug conjugates in terms of safety, the analyst tells investors in a research note.
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