The chart below shows how VYGR performed 10 days before and after its earnings report, based on data from the past quarters. Typically, VYGR sees a -4.25% change in stock price 10 days leading up to the earnings, and a -3.32% change 10 days following the report. On the earnings day itself, the stock moves by +4.13%. This data can give you a slight idea of what to expect for the next quarter's release.
Positive
Strong Cash Position: Voyager Therapeutics reported a strong cash position of $345 million at the end of Q3 2024, expected to provide runway into 2027.
Alzheimer's Drug Trial Progress: The company completed enrollment and dosing in the single ascending dose trial of VY7523, their anti-tau antibody for Alzheimer's disease.
Tau Targeting Approaches: Voyager is advancing two approaches to targeting tau, including their anti-tau antibody VY7523 and tau-silencing gene therapy, both of which are high priorities.
Clinical Development Update: The company expects to report topline safety and pharmacokinetic data in the first half of next year, indicating progress in their clinical development.
Strengthening Research Partnerships: Voyager's partnerships with leading experts in neurology and gene therapy continue to strengthen, enhancing their research capabilities.
Negative
Endpoint Not Achieved: The primary endpoint, CDR sum of boxes, was not met in the full study population.
Tau Accumulation Inhibition: The bepranemab inhibited the accumulation of tau in the human brain by 33% to 58%.
Cognitive Decline Reduction: The bepranemab demonstrated a cognitive decline by 21% to 25% versus placebo on ADAS-Cog14.
Tau Reduction in Trials: The bepranemab showed a reduction in pathological tau, as measured by PET imaging, but did not meet the primary endpoints in clinical trials.
Target Engagement Challenges: The study had insufficient target engagement with aggregated forms of amyloid beta, while the approved anti-amyloid antibodies all target the aggregated species.
Voyager Therapeutics, Inc. (VYGR) Q3 2024 Earnings Call Transcript
VYGR.O
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