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TNYA.O Overview

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ET
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0.000
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0.000(0.000%)Aft-market
ET
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Intellectia

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High
0.708
Open
0.680
VWAP
0.68
Vol
3.23M
Mkt Cap
145.87M
Low
0.668
Amount
2.21M
EV/EBITDA(TTM)
--
Total Shares
217.00M
EV
45.32M
EV/OCF(TTM)
--
P/S(TTM)
--
Tenaya Therapeutics, Inc. is a clinical-stage biotechnology company focused on discovering, developing, and delivering curative therapies that address the underlying drivers of heart disease. Its pipeline includes TN-201, TN-401, and TN-301. TN-201 is an adeno-associated virus serotype 9 (AAV9)-based gene therapy designed to deliver a working MYBPC3 gene to heart muscle cells via a single intravenous infusion, increasing MyBP-C protein levels to address the underlying cause of MYBPC3-associated HCM with the aim of halting or even reversing disease after a single dose. Its MyPEAK-1 Phase I b/2 clinical trial is an ongoing, multi-center, open-label, dose-escalating study designed to assess the safety, tolerability and clinical efficacy of a one-time intravenous infusion of TN-201 gene replacement therapy. TN-401 is its AAV9-based gene therapy being developed for the treatment of arrhythmogenic right ventricular cardiomyopathy (ARVC) due to disease-causing variants in the PKP2 gene.
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Events Timeline

(ET)
2026-04-17
09:00:00
Tenaya Therapeutics Receives FDA Orphan Drug Designation
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link
2026-03-11 (ET)
2026-03-11
16:30:00
Tenaya CEO Looks Forward to Gene Therapy Advances in 2026
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2026-03-09 (ET)
2026-03-09
08:40:00
Tenaya Therapeutics Presents Preclinical Data on TN-301 at MDA 2026
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2026-03-05 (ET)
2026-03-05
08:40:00
Tenaya Therapeutics Partners with Alnylam to Develop Cardiovascular Disease Treatments
select
2026-01-09 (ET)
2026-01-09
08:40:00
Tenaya Therapeutics Updates Clinical Development Plans, Outlines 2026 Priorities
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News

seekingalpha
9.5
03-11seekingalpha
Tenaya Therapeutics Reports Q4 Results and Financing Update
  • Earnings Report: Tenaya Therapeutics reported a Q4 GAAP EPS of -$0.12, aligning with market expectations, indicating financial stability amid ongoing operations.
  • Cash Reserves Growth: As of December 31, 2025, the company's cash, cash equivalents, and marketable securities totaled $100.5 million, a significant increase from $61.4 million in 2024, enhancing financial flexibility for future initiatives.
  • Financing Update: The public offering in December 2025 raised net proceeds of $55.8 million after underwriting discounts and expenses, expected to sufficiently fund operations into the second half of 2027, supporting strategic growth plans.
  • Collaboration Prospects: Tenaya anticipates an upfront payment from its collaboration with Alnylam, which will further bolster its financial position and support ongoing research and operational activities.
Newsfilter
9.0
03-09Newsfilter
Tenaya's TN-301 Outperforms Givinostat in DMD Cardiomyopathy
  • Promising Preclinical Data: At the 2026 Muscular Dystrophy Association conference, Tenaya presented preclinical data showing that TN-301 significantly outperformed the approved pan-HDAC inhibitor Givinostat in improving muscle function and addressing DMD cardiomyopathy, highlighting its potential in treating cardiac, metabolic, and muscular diseases.
  • Multi-Modal Mechanism: TN-301 operates through multiple mechanisms, including reducing inflammation and improving mitochondrial function, effectively correcting DMD-associated cardiomyocyte defects, and restoring muscle strength to wild-type levels in mouse models at a low dose of 3 mg/kg, showcasing its superior therapeutic effects.
  • Good Safety Profile: In a Phase 1 clinical trial involving healthy adults, TN-301 demonstrated good tolerability across a wide dose range without serious adverse events or dose-limiting toxicities, indicating its safety and efficacy for clinical applications.
  • Future Development Plans: Tenaya plans to advance TN-301 into Phase 2 clinical development targeting heart failure and DMD, aiming to address significant unmet needs in current treatments and drive the company's strategic growth in the biopharmaceutical sector.
stocktwits
7.5
03-06stocktwits
Tenaya Partners with Alnylam for Heart Drug Development
  • Collaboration Details: Tenaya Therapeutics has entered into a partnership with Alnylam Pharmaceuticals to validate up to 15 gene targets, potentially earning up to $1.13 billion in development and commercial milestone payments, highlighting the significant potential in heart disease drug development.
  • Upfront Payment Structure: Under the agreement, Tenaya will receive up to $10 million as an upfront payment, which not only provides funding for its research but also lays the groundwork for subsequent drug development efforts.
  • Market Reaction Analysis: Following the announcement, Tenaya's stock surged 41% during regular trading but pulled back 5% in after-hours trading, reflecting a blend of initial market optimism and subsequent caution regarding the collaboration.
  • Investor Sentiment Shift: On the Stocktwits platform, retail sentiment around TNYA stock shifted from 'bearish' to 'bullish' over the past 24 hours, indicating investor optimism about Tenaya's future gene therapy TN401, especially in the absence of curative competition.
Yahoo Finance
4.5
03-05Yahoo Finance
Health Care Stocks Decline, NYSE Health Care Index Drops 2.3%
  • Overall Decline in Health Care Stocks: On Thursday afternoon, health care stocks broadly fell, with the NYSE Health Care Index dropping 2.3%, reflecting market concerns about the sector's outlook, which could impact investor confidence and lead to capital outflows.
  • Diminished Market Sentiment: The downward trend in the health care sector may be linked to overall economic uncertainty, as investors grow increasingly wary of potential policy changes and regulatory pressures, thereby affecting stock performance.
  • Investor Reactions: In light of the decline in health care stocks, investors may reassess their portfolios, seeking more defensive asset allocations to mitigate potential market volatility and risks.
  • Uncertain Industry Outlook: The short-term performance of the health care sector may be influenced by multiple factors, including policy changes and fluctuations in market demand, prompting investors to closely monitor developments to adjust their investment strategies.
Benzinga
2.0
03-05Benzinga
Tenaya Therapeutics Partners with Alnylam for Genetic Research
  • Collaboration Agreement: Tenaya Therapeutics has entered into a research collaboration with Alnylam Pharmaceuticals focused on identifying genetic targets for cardiovascular diseases, with Tenaya set to validate up to 15 gene targets and potentially receive $10 million upfront and up to $1.13 billion in milestone payments, significantly enhancing its research capabilities.
  • Technical Advantages: Tenaya employs human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) for high-throughput genetic target identification, alongside engineered heart tissue and preclinical in vivo models for validation, having generated over 150 genetic targets that contribute to the development of clinical-stage candidates.
  • Clinical Trial Progress: In December 2025, Tenaya shared interim data from the RIDGE-1 Phase 1b/2 trial of TN-401 gene therapy for rare inherited heart disease, reporting safety, biopsy, and arrhythmia results from three patients, indicating the therapy's potential in treating such conditions.
  • Market Performance Analysis: Despite a 31.20% increase to 76 cents, Tenaya's stock remains 29.1% and 23.6% below its 100-day and 200-day simple moving averages, indicating a bearish trend in the medium to long term, with analysts generally rating it as a
seekingalpha
7.5
03-05seekingalpha
Tenaya Therapeutics Partners with Alnylam for Up to $1.1B Cardiovascular Drug Collaboration
  • Collaboration Agreement: Tenaya Therapeutics has signed a research collaboration with Alnylam Pharmaceuticals worth up to $1.1 billion, aimed at discovering 15 genetic targets associated with cardiovascular diseases, showcasing the company's strong potential in the biotech sector.
  • Upfront Payment and Milestone Rewards: Under the terms, Tenaya will receive up to $10 million as an upfront payment and is eligible for an additional $1.13 billion based on development and commercial milestones, significantly enhancing the company's liquidity and supporting its R&D activities.
  • Strategic Importance: CEO Faraz Ali emphasized that this multi-target collaboration underscores Tenaya's commitment to rigorous science and leverages its proprietary capabilities to drive the discovery and development of cardiovascular candidates, further solidifying its position in the biopharmaceutical industry.
  • Positive Market Reaction: Following the announcement of the collaboration, Tenaya's stock rose approximately 10% in premarket trading, reflecting investor optimism regarding the potential of this partnership, which may enhance the company's market recognition and future growth prospects.
Wall Street analysts forecast TNYA.O stock price to rise
8 Analyst Rating
Wall Street analysts forecast TNYA.O stock price to rise
8 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
2.00
Averages
9.14
High
40.00
Current: 0.000
sliders
Low
2.00
Averages
9.14
High
40.00
Morgan Stanley
Overweight
downgrade
$5 -> $2
AI Analysis
2026-01-08
Reason
Morgan Stanley
Price Target
$5 -> $2
AI Analysis
2026-01-08
downgrade
Overweight
Reason
Morgan Stanley lowered the firm's price target on Tenaya Therapeutics to $2 from $5 and keeps an Overweight rating on the shares. The firm sees a continuation of U.S. small-to-mid cap biotech's outperformance in 2026 as commercial names transition from "capital consumers to producers" and Large Cap Biopharma faces a looming patent cliff, the analyst tells investors in an outlook note for the group.
Canaccord
Buy
downgrade
$6 -> $4
2025-12-18
Reason
Canaccord
Price Target
$6 -> $4
2025-12-18
downgrade
Buy
Reason
Canaccord lowered the firm's price target on Tenaya Therapeutics to $4 from $6 and keeps a Buy rating on the shares. The firm two key updates from the company; the lifting of the clinical hold on the MyPEAK-1 trial of TN-201 by the FDA and the first look at interim data from the RIDGE-1 Ph1B clinical trial of TN-401 for PKP2-associated ARVC.
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Valuation Metrics

The current forward P/E ratio for Tenaya Therapeutics Inc (TNYA.O) is 0.00, compared to its 5-year average forward P/E of -2.67. For a more detailed relative valuation and DCF analysis to assess Tenaya Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-2.67
Current PE
0.00
Overvalued PE
-0.37
Undervalued PE
-4.97

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-1.93
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
1.54
Undervalued EV/EBITDA
-5.39

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
62.45
Current PS
0.00
Overvalued PS
200.18
Undervalued PS
-75.28

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Frequently Asked Questions

What is Tenaya Therapeutics Inc (TNYA.O) stock price today?

The current price of TNYA.O is 0.6722 USD — it has decreased -1.75

What is Tenaya Therapeutics Inc (TNYA.O)'s business?

Tenaya Therapeutics, Inc. is a clinical-stage biotechnology company focused on discovering, developing, and delivering curative therapies that address the underlying drivers of heart disease. Its pipeline includes TN-201, TN-401, and TN-301. TN-201 is an adeno-associated virus serotype 9 (AAV9)-based gene therapy designed to deliver a working MYBPC3 gene to heart muscle cells via a single intravenous infusion, increasing MyBP-C protein levels to address the underlying cause of MYBPC3-associated HCM with the aim of halting or even reversing disease after a single dose. Its MyPEAK-1 Phase I b/2 clinical trial is an ongoing, multi-center, open-label, dose-escalating study designed to assess the safety, tolerability and clinical efficacy of a one-time intravenous infusion of TN-201 gene replacement therapy. TN-401 is its AAV9-based gene therapy being developed for the treatment of arrhythmogenic right ventricular cardiomyopathy (ARVC) due to disease-causing variants in the PKP2 gene.

What is the price predicton of TNYA.O Stock?

Wall Street analysts forecast TNYA.O stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for TNYA.O is9.14 USD with a low forecast of 2.00 USD and a high forecast of 40.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Tenaya Therapeutics Inc (TNYA.O)'s revenue for the last quarter?

Tenaya Therapeutics Inc revenue for the last quarter amounts to -20.77M USD, decreased -15.73

What is Tenaya Therapeutics Inc (TNYA.O)'s earnings per share (EPS) for the last quarter?

Tenaya Therapeutics Inc. EPS for the last quarter amounts to -14007000.00 USD, decreased -24.66

How many employees does Tenaya Therapeutics Inc (TNYA.O). have?

Tenaya Therapeutics Inc (TNYA.O) has 70 emplpoyees as of April 26 2026.

What is Tenaya Therapeutics Inc (TNYA.O) market cap?

Today TNYA.O has the market capitalization of 145.87M USD.