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SLNO Should I Buy

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Intellectia

Should You Buy Soleno Therapeutics Inc (SLNO) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Hold
Latest Price
33.480
1 Day change
9.99%
52 Week Range
90.320
Analysis Updated At
2026/03/27
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Soleno Therapeutics Inc (SLNO) is not a good buy for a beginner investor with a long-term strategy at this time. The stock is facing significant negative catalysts, including insider selling, legal challenges, and weak technical indicators. Despite some positive analyst ratings and a strong gross margin, the company's financial performance has deteriorated, and the market sentiment remains negative. Given the investor's impatience and unwillingness to wait for optimal entry points, holding off on this investment is recommended.

Technical Analysis

The technical indicators for SLNO are bearish. The MACD histogram is negative (-0.321) and contracting, RSI_6 is at 27.958 (neutral zone), and the moving averages are bearish (SMA_200 > SMA_20 > SMA_5). The stock is trading below key support levels, with S1 at 30.66 and S2 at 29.117, indicating potential further downside.

Options Data

Neutral
Open Interest Put-Call Ratio
Bearish
Option Volume Put-Call Ratio

Technical Summary

StrongSellSellNeutralBuyStrongBuydotted line Image
Sell
7
Buy
5

Positive Catalysts

  • Analysts maintain a generally positive long-term outlook, with multiple firms rating the stock as a Buy or Outperform. The company has a strong gross margin of 99.06% and a promising commercial trajectory for its Vykat XR product.

Neutral/Negative Catalysts

  • The company is facing multiple class action lawsuits related to safety concerns with its DCCR drug, which has significantly impacted investor sentiment. Insider selling has increased by 1314.42% over the last month, and there are no significant hedge fund trading trends. The stock's financial performance in Q4 2025 showed a sharp decline in net income (-176.71% YoY) and EPS (-156.69% YoY).

Financial Performance

In Q4 2025, revenue remained flat YoY at $91.73 million. However, net income dropped significantly to $42.94 million (-176.71% YoY), and EPS fell to 0.72 (-156.69% YoY). Despite a strong gross margin of 99.06%, the financial performance indicates declining profitability.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

Analysts have lowered price targets recently, with Oppenheimer reducing its target to $80 from $110 and H.C. Wainwright lowering it to $100 from $120. However, they maintain Buy or Outperform ratings, citing a solid commercial outlook and expected revenue growth in FY26.

Wall Street analysts forecast SLNO stock price to rise
8 Analyst Rating
Wall Street analysts forecast SLNO stock price to rise
8 Buy
0 Hold
0 Sell
Strong Buy
Current: 30.440
sliders
Low
75
Averages
110.5
High
125
Current: 30.440
sliders
Low
75
Averages
110.5
High
125
Oppenheimer
Oppenheimer
Outperform
downgrade
$110 -> $80
AI Analysis
2026-03-18
Reason
Oppenheimer
Oppenheimer
Price Target
$110 -> $80
AI Analysis
2026-03-18
downgrade
Outperform
Reason
Oppenheimer lowered the firm's price target on Soleno Therapeutics to $80 from $110 and keeps an Outperform rating on the shares. The firm has revised its Soleno model to project a slower U.S. launch ramp vs. its prior estimates as well as reflect a go-it-alone scenario for European commercialization following recent management commentary. NULLtheless, Oppenheimer remains above consensus on 2026 top-line, and sees upcoming events as offering support to the shares.
H.C. Wainwright
Raghuram Selvaraju
Buy
downgrade
$120 -> $100
2026-03-04
Reason
H.C. Wainwright
Raghuram Selvaraju
Price Target
$120 -> $100
2026-03-04
downgrade
Buy
Reason
H.C. Wainwright analyst Raghuram Selvaraju lowered the firm's price target on Soleno Therapeutics to $100 from $120 and keeps a Buy rating on the shares post the Q4 report. The firm says the company has a solid commercial outlook. The analyst modulated the firm's peak market share expectations for Vykat in the U.S. to 20% of the total Prader-Willi syndrome market.
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