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PVLA Overview

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Intellectia

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High
118.905
Open
116.130
VWAP
117.28
Vol
155.66K
Mkt Cap
1.70B
Low
114.490
Amount
18.26M
EV/EBITDA(TTM)
--
Total Shares
14.34M
EV
1.42B
EV/OCF(TTM)
--
P/S(TTM)
--
Palvella Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing and commercializing therapies to treat patients suffering from serious, rare genetic skin diseases for which there are no FDA-approved therapies. The Company is developing a pipeline of product candidates based on its patented QTORIN platform, with an initial focus on serious, rare genetic skin diseases, many of which are lifelong in nature. Its QTORIN product candidates are developed to accommodate the cargo at high concentrations in order to drive sufficient drug to its target deep in the epidermis and dermis. The Company's lead product candidate, QTORIN 3.9% rapamycin anhydrous gel (QTORIN rapamycin), is being evaluated in the Phase III SELVA clinical trial in microcystic lymphatic malformations and the Phase II TOIVA clinical trial in cutaneous venous malformations.
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Events Timeline

(ET)
2026-05-27
07:50:00
Palvella Therapeutics Secures U.S. Patent for Qtorin Program
select
2026-05-20 (ET)
2026-05-20
16:40:00
Palvella Releases Qtorin Clinical Data, Plans FDA New Drug Application
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2026-05-15 (ET)
2026-05-15
07:50:00
Palvella Therapeutics Releases New Data from Qtorin Clinical Trial
select
2026-05-07 (ET)
2026-05-07
09:20:00
Palvella Reports Q1 Cash and Investments at $261.9M
select
2026-05-04 (ET)
2026-05-04
08:00:00
Palvella Therapeutics Begins LOTU Clinical Trial
select
2026-03-31 (ET)
2026-03-31
10:50:00
Palvella Therapeutics Q4 Earnings Report Released, Shares Up 11%
select

News

Newsfilter
9.0
05-27Newsfilter
Palvella Secures Patent for Skin Disease Treatment
  • Patent Protection Strengthened: Palvella Therapeutics has secured U.S. Patent No. 12,636,273, which covers treatments for porokeratosis, particularly disseminated superficial actinic porokeratosis (DSAP), providing robust intellectual property support for its QTORIN™ pitavastatin program, which is expected to enhance the company's market competitiveness in this area.
  • Clinical Trial Plans: Palvella plans to initiate a Phase 2 clinical trial of QTORIN™ pitavastatin in the second half of 2026, aiming to provide the first treatment option for over 50,000 diagnosed DSAP patients in the U.S., addressing unmet medical needs and filling a significant market gap.
  • Technological Innovation: QTORIN™ pitavastatin combines a next-generation statin with Palvella's QTORIN™ platform to enable targeted inhibition of the mevalonate pathway directly within affected skin tissue, potentially offering a novel and effective treatment option for patients with DSAP.
  • Broad Market Prospects: With Palvella's ongoing R&D and patent strategy in the dermatology field, the company is poised for significant market growth in the coming years, especially given the lack of FDA-approved therapies, where the successful launch of QTORIN™ pitavastatin could yield substantial economic benefits.
Newsfilter
8.5
05-21Newsfilter
Palvella Named Healthcare & Life Sciences Company of the Year at 2026 PACT Awards
  • Industry Recognition: Palvella Therapeutics has been awarded the Healthcare & Life Sciences Company of the Year at the 2026 Philadelphia Alliance for Capital and Technologies (PACT) Ecosystem Awards, highlighting its innovative efforts in treating rare skin diseases and vascular malformations, thereby enhancing its reputation in the biopharmaceutical sector.
  • Team Contribution: CEO Wes Kaupinen stated that this recognition reflects the passion and commitment of the Palvella team, indicating the company's ongoing efforts to advance novel therapies aimed at providing solutions for patients lacking FDA-approved treatment options.
  • Innovative Product Pipeline: Palvella is developing multiple product candidates based on its patented QTORIN™ platform, including QTORIN™ 3.9% rapamycin anhydrous gel for microcystic lymphatic malformations and cutaneous venous malformations, showcasing its potential for clinical and commercial progress.
  • Community Commitment: The PACT award selection criteria include contributions to the Greater Philadelphia life sciences ecosystem, and Palvella's recognition further solidifies its leadership position within the rapidly growing life sciences community, suggesting potential future capital formation and market impact.
Newsfilter
9.0
05-20Newsfilter
Palvella Releases SELVA and TOIVA Study Data
  • Clinical Trial Success: In the SELVA Phase 3 study, 100% of participants aged 6-11 were rated as 'Much Improved' or 'Very Much Improved' on the mLM-IGA scale, with a mean improvement of +2.46 (p<0.001), indicating QTORIN™ rapamycin's effectiveness in pediatric patients and paving the way for potential FDA approval.
  • Significant Bleeding Improvement: Among participants with moderate or worse bleeding at baseline, 87% (20/23) were rated as 'Much Improved' or 'Very Much Improved' at Week 24, with a mean improvement of +2.48 (p<0.001), demonstrating the drug's potential in managing severe symptoms.
  • High Patient Satisfaction: In the SELVA study, 100% of participants reported at least some satisfaction with QTORIN™ rapamycin, with 84% indicating they were extremely satisfied or satisfied, reflecting the drug's strong acceptance and therapeutic effect among patients.
  • Future Development Plans: Palvella plans to file a New Drug Application with the FDA in the second half of 2026, targeting approval in the first half of 2027, marking QTORIN™ rapamycin's potential to become the first FDA-approved treatment for microcystic lymphatic malformations.
Newsfilter
9.0
05-15Newsfilter
Palvella Releases New Data on QTORIN™ Efficacy
  • Clinical Trial Results: In the TOIVA trial, 100% of patients with bleeding at baseline showed a statistically significant average improvement of 2.5 points in cVM-IGA bleeding scores at Week 12 (p=0.003), indicating that QTORIN™ rapamycin significantly reduces bleeding and enhances patient quality of life, potentially becoming the first FDA-approved treatment.
  • Patient Satisfaction: All patients with bleeding at baseline reported being 'satisfied' or 'very satisfied' on the Treatment Satisfaction Questionnaire, highlighting QTORIN™ rapamycin's importance in improving overall treatment experience, which may enhance market acceptance.
  • Quality of Life Burden: Baseline patient interviews revealed the multidimensional impact of cutaneous venous malformations on patients' lives, including pain, functional limitations, and mental health issues, emphasizing the significance of patient-reported outcomes in clinical development and guiding future treatment directions.
  • Market Potential: With over 75,000 individuals in the U.S. suffering from cutaneous venous malformations and lacking effective treatments, the successful development of QTORIN™ rapamycin could not only fill a significant market gap but also provide Palvella with substantial commercial opportunities and competitive advantages.
seekingalpha
8.5
05-13seekingalpha
Palvella Therapeutics Successfully Transfers Stock Listing
  • Uplisting Milestone: Palvella Therapeutics announced the transfer of its common stock listing from the Nasdaq Capital Market to the Nasdaq Global Market, effective May 13, marking a significant advancement in its therapies targeting rare skin diseases and vascular malformations.
  • Enhanced Standards: The Nasdaq Global Market imposes stricter requirements regarding financial metrics, liquidity, and corporate governance, which will enhance Palvella's operational transparency and market credibility, potentially attracting more investor interest.
  • CEO Highlights Strategic Importance: CEO Wes Kaupinen emphasized that this uplisting is not only a crucial milestone for the company's development but also provides stronger market support for its future therapeutic solutions, particularly in the rare disease sector.
  • Future Sales Potential: Palvella plans to file for NDA for QTORIN rapamycin in the second half of 2026, with a projected peak U.S. sales potential exceeding $1 billion, indicating strong growth prospects in the rare dermatology market.
Newsfilter
8.5
05-13Newsfilter
Palvella Receives Approval for Nasdaq Global Market Uplisting
  • Uplisting Milestone: Palvella Therapeutics has received Nasdaq approval to transfer its common stock from the Nasdaq Capital Market to the Nasdaq Global Market, marking a significant step in the company's ongoing progress in developing potential first-in-disease therapies for rare skin diseases and vascular malformations.
  • Increased Market Visibility: CEO Wes Kaupinen stated that this transition will further elevate Palvella's visibility in the market, supporting its mission to provide innovative treatments for patients, particularly in areas lacking FDA-approved therapies.
  • Meeting Higher Standards: Palvella has satisfied the higher listing standards of the Nasdaq Global Market, which include requirements related to financial metrics, public float, liquidity, and corporate governance, demonstrating an enhancement in its financial health and operational capabilities.
  • Commitment to Compliance: The transfer requires no action from existing shareholders, and Palvella will continue to comply with all applicable Nasdaq listing standards and U.S. Securities and Exchange Commission reporting requirements, ensuring the company's transparency and compliance.
Wall Street analysts forecast PVLA stock price to rise
15 Analyst Rating
Wall Street analysts forecast PVLA stock price to rise
15 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
133.00
Averages
182.20
High
212.00
Current: 0.000
sliders
Low
133.00
Averages
182.20
High
212.00
Stephens
Stephens
initiated
$220
AI Analysis
2026-05-12
Reason
Stephens
Stephens
Price Target
$220
AI Analysis
2026-05-12
initiated
Reason
Stephens initiated coverage of Palvella Therapeutics with an Overweight rating and $220 price target. Palvella is a clinical-stage biopharmaceutical company leveraging its Qtorin platform to target rare genetic dermatologic conditions with no FDA approved therapies, the analyst tells investors in a research note. The firm says the company's lead asset, Qtorin rapamycin, is advancing across multiple indications. It believes the market underappreciates Palvella's potential penetration in the microcystic lymphatic malformations setting.
Chardan
Geulah Livshits
Buy
maintain
$210 -> $240
2026-03-31
Reason
Chardan
Geulah Livshits
Price Target
$210 -> $240
2026-03-31
maintain
Buy
Reason
Chardan analyst Geulah Livshits raised the firm's price target on Palvella Therapeutics to $240 from $210 and keeps a Buy rating on the shares. The company highlighted progress across its expanding topical therapy pipeline when reporting Q4 results, the analyst tells investors in a research note. The firm says Palvella's cash position should take it through initial approval and launch in microcystic lymphatic malformations.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for PVLA
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Valuation Metrics

The current forward P/E ratio for Palvella Therapeutics Inc (PVLA.O) is 0.00, compared to its 5-year average forward P/E of -12.97. For a more detailed relative valuation and DCF analysis to assess Palvella Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-12.97
Current PE
0.00
Overvalued PE
-6.12
Undervalued PE
-19.81

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-10.17
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
-2.75
Undervalued EV/EBITDA
-17.58

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
16691.04
Current PS
51.35
Overvalued PS
39157.05
Undervalued PS
-5774.96

Financials

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Whales Holding PVLA

S
Summit Partners Public Asset Management, LLC
Holding
PVLA
+37.54%
3M Return
P
Perceptive Advisors LLC
Holding
PVLA
+10.32%
3M Return
B
BVF Partners L.P.
Holding
PVLA
+3.71%
3M Return
F
Frazier Life Sciences Management, LP
Holding
PVLA
+1.66%
3M Return

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Frequently Asked Questions

What is Palvella Therapeutics Inc (PVLA) stock price today?

The current price of PVLA is 118.46 USD — it has increased 2.24

What is Palvella Therapeutics Inc (PVLA)'s business?

Palvella Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing and commercializing therapies to treat patients suffering from serious, rare genetic skin diseases for which there are no FDA-approved therapies. The Company is developing a pipeline of product candidates based on its patented QTORIN platform, with an initial focus on serious, rare genetic skin diseases, many of which are lifelong in nature. Its QTORIN product candidates are developed to accommodate the cargo at high concentrations in order to drive sufficient drug to its target deep in the epidermis and dermis. The Company's lead product candidate, QTORIN 3.9% rapamycin anhydrous gel (QTORIN rapamycin), is being evaluated in the Phase III SELVA clinical trial in microcystic lymphatic malformations and the Phase II TOIVA clinical trial in cutaneous venous malformations.

What is the price predicton of PVLA Stock?

Wall Street analysts forecast PVLA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for PVLA is182.20 USD with a low forecast of 133.00 USD and a high forecast of 212.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Palvella Therapeutics Inc (PVLA)'s revenue for the last quarter?

Palvella Therapeutics Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Palvella Therapeutics Inc (PVLA)'s earnings per share (EPS) for the last quarter?

Palvella Therapeutics Inc. EPS for the last quarter amounts to -1.20 USD, increased 62.16

How many employees does Palvella Therapeutics Inc (PVLA). have?

Palvella Therapeutics Inc (PVLA) has 29 emplpoyees as of June 01 2026.

What is Palvella Therapeutics Inc (PVLA) market cap?

Today PVLA has the market capitalization of 1.70B USD.