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PVLA Overview

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0.000(0.000%)
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0.000(0.000%)Aft-market
ET
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0.000
0.000(0.000%)
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ET
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Intellectia

Loading chart...

High
130.220
Open
128.930
VWAP
129.27
Vol
170.23K
Mkt Cap
1.86B
Low
128.250
Amount
22.00M
EV/EBITDA(TTM)
--
Total Shares
14.31M
EV
1.82B
EV/OCF(TTM)
--
P/S(TTM)
--
Palvella Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing and commercializing therapies to treat patients suffering from serious, rare genetic skin diseases for which there are no FDA-approved therapies. The Company is developing a pipeline of product candidates based on its patented QTORIN platform, with an initial focus on serious, rare genetic skin diseases, many of which are lifelong in nature. Its QTORIN product candidates are developed to accommodate the cargo at high concentrations in order to drive sufficient drug to its target deep in the epidermis and dermis. The Company's lead product candidate, QTORIN 3.9% rapamycin anhydrous gel (QTORIN rapamycin), is being evaluated in the Phase III SELVA clinical trial in microcystic lymphatic malformations and the Phase II TOIVA clinical trial in cutaneous venous malformations.
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Events Timeline

(ET)
2026-03-31
10:50:00
Palvella Therapeutics Q4 Earnings Report Released, Shares Up 11%
select
2026-03-16 (ET)
2026-03-16
07:40:00
Palvella Therapeutics Secures European Patent for QTORIN(TM) Product
select
2026-02-25 (ET)
2026-02-25
20:10:00
Deal Size Increased to $200M, Priced Below Last Close
select

News

Newsfilter
8.5
11:43 AMNewsfilter
PinnedPalvella Therapeutics Announces Clinical Results Presentation at ISSVA 2026
  • Clinical Results Presentation: Palvella Therapeutics announced that Dr. James Treat will present clinical results of QTORIN™ 3.9% rapamycin anhydrous gel at the ISSVA World Congress on May 20, 2026, marking a significant advancement in the treatment of rare skin diseases.
  • Research Highlights: The presentation will feature two late-breaking abstracts from the Phase 3 SELVA and Phase 2 TOIVA studies, emphasizing significant clinical improvements in treating microcystic lymphatic malformations and cutaneous venous malformations, potentially enhancing market recognition for the company's products.
  • Innovative Treatment Platform: Palvella's QTORIN™ platform focuses on developing therapies for serious rare skin diseases and vascular malformations, with ongoing clinical trials demonstrating promising efficacy, indicating potential for future FDA approvals.
  • Broad Market Potential: As the demand for treatments for rare diseases increases, the successful development of Palvella's product candidates like QTORIN™ rapamycin and QTORIN™ pitavastatin could yield substantial market opportunities and revenue growth for the company.
Newsfilter
5.0
04-13Newsfilter
Palvella Appoints New Board Member to Drive Rare Disease Innovation
  • New Board Member: Palvella Therapeutics has appointed John D. Doux, M.D., M.B.A. to its Board of Directors, whose extensive experience in dermatology and deep understanding of rare diseases will drive innovation in the company's focus on serious skin diseases and vascular malformations lacking FDA-approved treatments.
  • Industry Influence: Dr. Doux's 2015 editorial in the Journal of Investigative Dermatology highlighted the investment potential in rare skin disease treatments, indicating that the orphan disease business model has yet to be fully applied in dermatology, suggesting future investment opportunities and therapeutic breakthroughs.
  • Clinical and Investment Background: As a board-certified dermatologist and investor, Dr. Doux has served as an analyst at Palo Alto Investors LP since 2004, engaging in investments in multiple biotechnology companies, showcasing his expertise in advancing treatments for rare diseases.
  • Strategic Vision: Dr. Doux emphasized Palvella's patient-first approach and the reproducible business model based on the QTORIN™ platform, indicating the company's potential for long-term value creation in the rare skin disease and vascular malformation space, positioning it to become a leader in the industry.
Newsfilter
5.0
04-07Newsfilter
Palvella Appoints New Senior Vice President of Sales
  • Executive Appointment: Palvella Therapeutics has appointed Kent Taylor as Senior Vice President of Sales, bringing over 25 years of pharmaceutical experience, having previously held executive roles at Arcutis Biotherapeutics and Incyte, where he successfully led the launches of ZORYVE® and OPZELURA®, which is expected to significantly enhance Palvella's sales leadership and market insight.
  • Market Potential: Taylor will oversee the U.S. sales for Palvella's upcoming QTORIN™ rapamycin, targeting microcystic lymphatic malformations, which is anticipated to provide the first FDA-approved treatment for over 30,000 diagnosed patients in the U.S., addressing a significant unmet need in the market.
  • Strategic Development: Taylor's addition not only strengthens Palvella's market position in rare skin diseases and vascular malformations but also reflects the company's commitment to attracting top talent, aiming to build a robust sales organization to support future product launches and market expansion.
  • Industry Experience: Taylor's extensive experience in dermatology will facilitate closer collaborations with dermatologists, particularly pediatric dermatologists, further driving market acceptance and sales growth for the QTORIN™ platform.
seekingalpha
9.5
03-31seekingalpha
Palvella Therapeutics Reports FY Loss and Cash Position
  • Earnings Miss: Palvella Therapeutics reported a FY GAAP EPS of -$3.71, missing expectations by $0.19, indicating financial strain that could undermine investor confidence in the company's future prospects.
  • Cash Position: As of December 31, 2025, Palvella had cash and cash equivalents of $58.0 million, while anticipated equity financing in February 2026 is expected to yield approximately $215.8 million in net proceeds, highlighting a tight cash flow situation in the near term.
  • Financing Strategy: The company plans to bolster its capital structure through a $200 million share offering, which, despite current financial challenges, may provide necessary funding for future R&D and market expansion efforts.
  • Market Potential: Positioned as a potential first-in-class therapy in the rare dermatology market, Palvella's unique market opportunity remains attractive, and despite current financial setbacks, it could draw interest from long-term investors looking for growth potential.
Newsfilter
9.0
03-31Newsfilter
Palvella Plans NDA Submission for QTORIN™ Rapamycin in 2026
  • NDA Progress: Palvella is on track to submit the New Drug Application for QTORIN™ rapamycin in the second half of 2026, which, if approved, would be the first FDA-approved therapy for microcystic lymphatic malformations, potentially benefiting over 30,000 patients in the U.S. and representing significant market potential.
  • Trial Initiation: The company plans to initiate a Phase 3 trial for QTORIN™ rapamycin targeting cutaneous venous malformations in the second half of 2026, further expanding its treatment options in the rare skin disease sector and enhancing its competitive position in the market.
  • Financial Improvement: As of December 31, 2025, Palvella reported cash and cash equivalents of $58 million, with an expected net proceeds of approximately $230 million from a February 2026 financing, significantly strengthening the company's financial position to support R&D and market launch efforts.
  • Significant R&D Advances: In February 2026, the SELVA study demonstrated statistically significant improvement in the primary endpoint for QTORIN™ rapamycin in microcystic lymphatic malformations, with 95% of participants showing improvement during the evaluation period, indicating the drug's efficacy and good tolerability, which may expedite the FDA approval process.
Newsfilter
9.0
03-30Newsfilter
Review Highlights Treatment Strategies for Lymphatic Malformations
  • Clinical Strategy Differences: A newly published review emphasizes the significant clinical management differences between microcystic and macrocystic lymphatic malformations, highlighting the lack of FDA-approved therapies for microcystic lesions, which underscores the urgent medical need and may drive future clinical trial designs targeting specific subtypes.
  • Importance of Early Intervention: The article stresses the importance of early therapeutic intervention in children to reduce the risk of long-term complications, indicating that timely treatment could improve patient quality of life and reduce healthcare costs over time.
  • Support for QTORIN™ Therapy: QTORIN™ 3.9% rapamycin anhydrous gel achieved its primary endpoint in the Phase 3 SELVA trial, providing scientific rationale for its potential as a targeted therapy for microcystic lymphatic malformations, which may offer new treatment options for patients.
  • Market Potential Analysis: With over 30,000 diagnosed patients in the U.S. lacking effective treatment options, Palvella Therapeutics' research and product development could fill this market gap, presenting significant commercial potential for the company.
Wall Street analysts forecast PVLA stock price to rise
15 Analyst Rating
Wall Street analysts forecast PVLA stock price to rise
15 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
133.00
Averages
182.20
High
212.00
Current: 0.000
sliders
Low
133.00
Averages
182.20
High
212.00
Chardan
Geulah Livshits
Buy
maintain
$210 -> $240
AI Analysis
2026-03-31
Reason
Chardan
Geulah Livshits
Price Target
$210 -> $240
AI Analysis
2026-03-31
maintain
Buy
Reason
Chardan analyst Geulah Livshits raised the firm's price target on Palvella Therapeutics to $240 from $210 and keeps a Buy rating on the shares. The company highlighted progress across its expanding topical therapy pipeline when reporting Q4 results, the analyst tells investors in a research note. The firm says Palvella's cash position should take it through initial approval and launch in microcystic lymphatic malformations.
Oppenheimer
Oppenheimer
Outperform
maintain
$200 -> $210
2026-03-31
Reason
Oppenheimer
Oppenheimer
Price Target
$200 -> $210
2026-03-31
maintain
Outperform
Reason
Oppenheimer raised the firm's price target on Palvella Therapeutics to $210 from $200 and keeps an Outperform rating on the shares. The firm notes Palvella reported Q4 net loss of $12.7M vs. its $11.4M expectations on one-time expenses. Palvella shares have receded again, and Oppenheimer believes provide another attractive entry ahead of updates through the rest of the year. The firm ascribes the pullback largely to market volatility and low float. Today, it appears the market is taking notice as shares have climbed about 13% vs XBI's 7%. Oppenheimer thinks many aspects of Palvella shares remain highly underappreciated as the stock at current valuation appears primarily driven by MLM expectations, and accounts little for CVM, with no value ascribed for DSAP/angiokeratomas, nor additional pipeline unveils beyond that.
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Valuation Metrics

The current forward P/E ratio for Palvella Therapeutics Inc (PVLA.O) is 0.00, compared to its 5-year average forward P/E of -12.97. For a more detailed relative valuation and DCF analysis to assess Palvella Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-12.97
Current PE
0.00
Overvalued PE
-6.12
Undervalued PE
-19.81

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-10.17
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
-2.75
Undervalued EV/EBITDA
-17.58

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
18213.49
Current PS
53.68
Overvalued PS
41088.29
Undervalued PS
-4661.31

Financials

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Whales Holding PVLA

S
Summit Partners Public Asset Management, LLC
Holding
PVLA
+26.00%
3M Return
P
Perceptive Advisors LLC
Holding
PVLA
+14.76%
3M Return
S
Suvretta Capital Management, LLC
Holding
PVLA
+12.38%
3M Return
F
Frazier Life Sciences Management, LP
Holding
PVLA
+6.89%
3M Return
B
BVF Partners L.P.
Holding
PVLA
+6.03%
3M Return

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Frequently Asked Questions

What is Palvella Therapeutics Inc (PVLA) stock price today?

The current price of PVLA is 129.33 USD — it has decreased -0.52

What is Palvella Therapeutics Inc (PVLA)'s business?

Palvella Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing and commercializing therapies to treat patients suffering from serious, rare genetic skin diseases for which there are no FDA-approved therapies. The Company is developing a pipeline of product candidates based on its patented QTORIN platform, with an initial focus on serious, rare genetic skin diseases, many of which are lifelong in nature. Its QTORIN product candidates are developed to accommodate the cargo at high concentrations in order to drive sufficient drug to its target deep in the epidermis and dermis. The Company's lead product candidate, QTORIN 3.9% rapamycin anhydrous gel (QTORIN rapamycin), is being evaluated in the Phase III SELVA clinical trial in microcystic lymphatic malformations and the Phase II TOIVA clinical trial in cutaneous venous malformations.

What is the price predicton of PVLA Stock?

Wall Street analysts forecast PVLA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for PVLA is182.20 USD with a low forecast of 133.00 USD and a high forecast of 212.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Palvella Therapeutics Inc (PVLA)'s revenue for the last quarter?

Palvella Therapeutics Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Palvella Therapeutics Inc (PVLA)'s earnings per share (EPS) for the last quarter?

Palvella Therapeutics Inc. EPS for the last quarter amounts to -1.07 USD, decreased -10.83

How many employees does Palvella Therapeutics Inc (PVLA). have?

Palvella Therapeutics Inc (PVLA) has 29 emplpoyees as of April 20 2026.

What is Palvella Therapeutics Inc (PVLA) market cap?

Today PVLA has the market capitalization of 1.86B USD.