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PVLA Overview

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0.000
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Intellectia

Loading chart...

High
114.530
Open
112.290
VWAP
111.27
Vol
281.74K
Mkt Cap
1.49B
Low
108.630
Amount
31.35M
EV/EBITDA(TTM)
--
Total Shares
13.44M
EV
1.38B
EV/OCF(TTM)
--
P/S(TTM)
--
Palvella Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing and commercializing therapies to treat patients suffering from serious, rare genetic skin diseases for which there are no FDA-approved therapies. The Company is developing a pipeline of product candidates based on its patented QTORIN platform, with an initial focus on serious, rare genetic skin diseases, many of which are lifelong in nature. Its QTORIN product candidates are developed to accommodate the cargo at high concentrations in order to drive sufficient drug to its target deep in the epidermis and dermis. The Company's lead product candidate, QTORIN 3.9% rapamycin anhydrous gel (QTORIN rapamycin), is being evaluated in the Phase III SELVA clinical trial in microcystic lymphatic malformations and the Phase II TOIVA clinical trial in cutaneous venous malformations.
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Events Timeline

(ET)
2026-03-16
07:40:00
Palvella Therapeutics Secures European Patent for QTORIN(TM) Product
select
2026-02-25 (ET)
2026-02-25
20:10:00
Deal Size Increased to $200M, Priced Below Last Close
select
2026-02-24 (ET)
2026-02-24
16:30:00
TD Cowen and Others Act as Joint Bookrunning Managers for Offering
select

News

seekingalpha
9.5
12:12 PMseekingalpha
Palvella Therapeutics Reports FY Loss and Cash Position
  • Earnings Miss: Palvella Therapeutics reported a FY GAAP EPS of -$3.71, missing expectations by $0.19, indicating financial strain that could undermine investor confidence in the company's future prospects.
  • Cash Position: As of December 31, 2025, Palvella had cash and cash equivalents of $58.0 million, while anticipated equity financing in February 2026 is expected to yield approximately $215.8 million in net proceeds, highlighting a tight cash flow situation in the near term.
  • Financing Strategy: The company plans to bolster its capital structure through a $200 million share offering, which, despite current financial challenges, may provide necessary funding for future R&D and market expansion efforts.
  • Market Potential: Positioned as a potential first-in-class therapy in the rare dermatology market, Palvella's unique market opportunity remains attractive, and despite current financial setbacks, it could draw interest from long-term investors looking for growth potential.
Newsfilter
9.0
11:40 AMNewsfilter
Palvella Plans NDA Submission for QTORIN™ Rapamycin in 2026
  • NDA Progress: Palvella is on track to submit the New Drug Application for QTORIN™ rapamycin in the second half of 2026, which, if approved, would be the first FDA-approved therapy for microcystic lymphatic malformations, potentially benefiting over 30,000 patients in the U.S. and representing significant market potential.
  • Trial Initiation: The company plans to initiate a Phase 3 trial for QTORIN™ rapamycin targeting cutaneous venous malformations in the second half of 2026, further expanding its treatment options in the rare skin disease sector and enhancing its competitive position in the market.
  • Financial Improvement: As of December 31, 2025, Palvella reported cash and cash equivalents of $58 million, with an expected net proceeds of approximately $230 million from a February 2026 financing, significantly strengthening the company's financial position to support R&D and market launch efforts.
  • Significant R&D Advances: In February 2026, the SELVA study demonstrated statistically significant improvement in the primary endpoint for QTORIN™ rapamycin in microcystic lymphatic malformations, with 95% of participants showing improvement during the evaluation period, indicating the drug's efficacy and good tolerability, which may expedite the FDA approval process.
Newsfilter
9.0
03-30Newsfilter
Review Highlights Treatment Strategies for Lymphatic Malformations
  • Clinical Strategy Differences: A newly published review emphasizes the significant clinical management differences between microcystic and macrocystic lymphatic malformations, highlighting the lack of FDA-approved therapies for microcystic lesions, which underscores the urgent medical need and may drive future clinical trial designs targeting specific subtypes.
  • Importance of Early Intervention: The article stresses the importance of early therapeutic intervention in children to reduce the risk of long-term complications, indicating that timely treatment could improve patient quality of life and reduce healthcare costs over time.
  • Support for QTORIN™ Therapy: QTORIN™ 3.9% rapamycin anhydrous gel achieved its primary endpoint in the Phase 3 SELVA trial, providing scientific rationale for its potential as a targeted therapy for microcystic lymphatic malformations, which may offer new treatment options for patients.
  • Market Potential Analysis: With over 30,000 diagnosed patients in the U.S. lacking effective treatment options, Palvella Therapeutics' research and product development could fill this market gap, presenting significant commercial potential for the company.
Newsfilter
5.0
03-27Newsfilter
Palvella Launches QTORIN™ Novel Skin Treatment Drug
  • Innovative Drug Development: Palvella Therapeutics has launched QTORIN™ 3.9% rapamycin anhydrous gel, designed to address crystallization and penetration issues of rapamycin in skin disease treatment, which is expected to significantly enhance its application potential in mTOR-driven skin diseases.
  • Clinical Trial Success: The Phase 3 SELVA study of QTORIN™ rapamycin in microcystic lymphatic malformations met its primary endpoint, demonstrating statistically significant improvement in the Microcystic Lymphatic Malformation Investigator Global Assessment (p<0.001), laying the groundwork for its use in other rare skin diseases.
  • Patient Burden Study: A qualitative study on the rare genetic skin disease porokeratosis revealed significant physical and psychosocial burdens on patients, highlighting the urgency of developing targeted therapies, especially in the absence of FDA-approved treatments.
  • Future Development Plans: Palvella plans to initiate a Phase 2 clinical trial for disseminated superficial actinic porokeratosis in the second half of 2026, further expanding its treatment pipeline in the rare skin disease sector.
Fool
5.0
03-25Fool
Palvella COO Sells Stock Options Amid Strong Market Surge
  • Executive Transaction Overview: Kathleen Goin, COO of Palvella Therapeutics, exercised 4,302 options and immediately sold an equivalent number of common shares on March 18, 2026, with a transaction value of approximately $508,000 based on a weighted average purchase price of $117.99 per share, indicating a liquidity-driven decision by the executive.
  • Impact on Holdings: This transaction reduced Goin's direct common stock holdings to zero, although she retains indirect exposure through stock options, reflecting a strategic approach to liquidity management by the executive.
  • Transaction Pattern Analysis: The 4,302-share transaction matches the median size of Goin's prior option-related activities over the past four months, suggesting that this liquidity-motivated sale aligns with structured trading plans rather than signaling a lack of confidence in the company's future.
  • Market Outlook: Despite Palvella's stock surging 340% over the past year, Goin's sale has not alarmed investors, instead highlighting the company's confidence in advancing its New Drug Application and clinical validation efforts, with future stock performance likely hinging on execution and regulatory timelines.
NASDAQ.COM
5.0
03-25NASDAQ.COM
Palvella Executive Sells Shares Amid Positive Developments
  • Executive Share Sale: Kathleen Goin, COO of Palvella Therapeutics, sold 4,302 common shares for approximately $508,000 on March 18, 2026, reflecting executive liquidity management following a significant stock surge.
  • Options Exercise and Sale: The sale stemmed from options exercised by Goin, with the transaction based on a weighted average purchase price of $117.99 as per SEC Form 4, indicating that this was a pre-planned liquidity event without indirect holdings or gifts involved.
  • Positive Clinical Progress: Palvella recently reported positive Phase 3 results for its lead candidate QTORIN rapamycin, with 95% of participants showing significant improvement, and plans to submit a New Drug Application in the second half of 2026, potentially making it the first approved treatment for microcystic lymphatic malformations.
  • Funding and Market Response: The company raised about $230 million through an upsized equity offering, providing financial support for development and commercialization, which, combined with clinical validation, has bolstered investor confidence, although analysts remain cautious about future performance.
Wall Street analysts forecast PVLA stock price to rise
15 Analyst Rating
Wall Street analysts forecast PVLA stock price to rise
15 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
133.00
Averages
182.20
High
212.00
Current: 0.000
sliders
Low
133.00
Averages
182.20
High
212.00
H.C. Wainwright
Buy
maintain
$255 -> $270
AI Analysis
2026-03-24
Reason
H.C. Wainwright
Price Target
$255 -> $270
AI Analysis
2026-03-24
maintain
Buy
Reason
H.C. Wainwright raised the firm's price target on Palvella Therapeutics to $270 from $255 and keeps a Buy rating on the shares after meeting with a key opinion leader. The doctor viewed Palvella's microcystic lymphatic malformations data as clinical validation that Qtorin can deliver drug into the dermis, not just the epidermis, the analyst tells investors in a research note. The firm believes this "meaningfully broadens" the Qtorin platform opportunity. H.C. Wainwright is now "incrementally more constructive" on Qtorin as a platform story, not just a microcystic lymphatic malformations story.
Chardan
Buy
maintain
$200 -> $220
2026-03-01
Reason
Chardan
Price Target
$200 -> $220
2026-03-01
maintain
Buy
Reason
Chardan raised the firm's price target on Palvella Therapeutics to $220 from $200 and keeps a Buy rating on the shares. The firm says the "impressive" Phase 3 SELVA data for Qtorin rapamycin in microcystic lymphatic malformations positions Palvella for a "highly compelling label." Qtorin rapamycin is well positioned to become the first FDA-approved therapy for the 30,000-patient U.S. microcystic lymphatic malformations market, potentially capturing blockbuster status in a chronic-use population, the analyst tells investors in a research note.
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Valuation Metrics

The current forward P/E ratio for Palvella Therapeutics Inc (PVLA.O) is -25.63, compared to its 5-year average forward P/E of -13.02. For a more detailed relative valuation and DCF analysis to assess Palvella Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-13.02
Current PE
-25.63
Overvalued PE
-6.14
Undervalued PE
-19.90

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-10.23
Current EV/EBITDA
-24.36
Overvalued EV/EBITDA
-2.77
Undervalued EV/EBITDA
-17.69

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
11851.16
Current PS
53466.81
Overvalued PS
31574.16
Undervalued PS
-7871.83

Financials

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Whales Holding PVLA

S
Summit Partners Public Asset Management, LLC
Holding
PVLA
+6.73%
3M Return
P
Perceptive Advisors LLC
Holding
PVLA
-0.51%
3M Return
B
BVF Partners L.P.
Holding
PVLA
-2.32%
3M Return
F
Frazier Life Sciences Management, LP
Holding
PVLA
-3.41%
3M Return
S
Suvretta Capital Management, LLC
Holding
PVLA
-12.21%
3M Return

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Frequently Asked Questions

What is Palvella Therapeutics Inc (PVLA) stock price today?

The current price of PVLA is 110.66 USD — it has decreased -1.52

What is Palvella Therapeutics Inc (PVLA)'s business?

Palvella Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing and commercializing therapies to treat patients suffering from serious, rare genetic skin diseases for which there are no FDA-approved therapies. The Company is developing a pipeline of product candidates based on its patented QTORIN platform, with an initial focus on serious, rare genetic skin diseases, many of which are lifelong in nature. Its QTORIN product candidates are developed to accommodate the cargo at high concentrations in order to drive sufficient drug to its target deep in the epidermis and dermis. The Company's lead product candidate, QTORIN 3.9% rapamycin anhydrous gel (QTORIN rapamycin), is being evaluated in the Phase III SELVA clinical trial in microcystic lymphatic malformations and the Phase II TOIVA clinical trial in cutaneous venous malformations.

What is the price predicton of PVLA Stock?

Wall Street analysts forecast PVLA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for PVLA is182.20 USD with a low forecast of 133.00 USD and a high forecast of 212.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Palvella Therapeutics Inc (PVLA)'s revenue for the last quarter?

Palvella Therapeutics Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Palvella Therapeutics Inc (PVLA)'s earnings per share (EPS) for the last quarter?

Palvella Therapeutics Inc. EPS for the last quarter amounts to -1.03 USD, decreased -73.86

How many employees does Palvella Therapeutics Inc (PVLA). have?

Palvella Therapeutics Inc (PVLA) has 14 emplpoyees as of March 31 2026.

What is Palvella Therapeutics Inc (PVLA) market cap?

Today PVLA has the market capitalization of 1.49B USD.