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PRTC Overview

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ET
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ET
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Intellectia

Loading chart...

High
18.320
Open
18.320
VWAP
18.36
Vol
3.25K
Mkt Cap
444.24M
Low
18.320
Amount
59.68K
EV/EBITDA(TTM)
--
Total Shares
24.34M
EV
112.97M
EV/OCF(TTM)
--
P/S(TTM)
67.26
PureTech Health plc is a clinical-stage company dedicated to giving life to new classes of medicine to change the lives of patients with devastating diseases. The Company is engaged in the development of around 29 therapeutics and therapeutic candidates, including three that have been approved by the United States Food and Drug Administration. A number of these programs are advanced by the Company or its Founded Entities in various indications and stages of clinical development. Its primary programs include LYT-100 and LYT-200. Deupirfenidone (LYT-100) is being developed as a potential new standard of care (SOC) for the treatment of idiopathic pulmonary fibrosis (IPF). LYT-200 is an anti-galectin-9 monoclonal antibody (mAb) being developed for the treatment of hematological malignancies, including acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS), as well as solid tumors, including head and neck cancers, with a focus on metastatic disease.
Show More

Events Timeline

(ET)
2026-04-02
08:30:00
PureTech Health Announces ELEVATE IPF Trial Results
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2026-04-02
07:20:00
PureTech Health's Seaport Therapeutics Advances GlyphAgo Clinical Trials
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2026-02-19 (ET)
2026-02-19
12:50:00
PureTech Health Receives FDA and EU Orphan Drug Designation
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2025-12-18 (ET)
2025-12-18
05:20:00
PureTech Health Appoints Robert Lyne as CEO
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2025-12-08 (ET)
2025-12-08
05:30:00
PureTech Health Completes FDA Phase 2 Meeting, Advances LYT-100 Development
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2025-10-22 (ET)
2025-10-22
05:24:51
PureTech Health unveils fresh insights from the ELEVATE IPF trial
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2025-09-11 (ET)
2025-09-11
07:16:10
PureTech Health announces first patient dosed in GlyphAgo study by Seaport Therapeutics
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2025-08-13 (ET)
2025-08-13
12:18:04
PureTech says Vedanta ulcerative colitis study missed endpoint
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2025-08-06 (ET)
2025-08-06
09:34:09
DiaMedica Therapeutics CMO Lorianne Masuoka resigns, Julie Krop succeeds
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2025-07-17 (ET)
2025-07-17
07:15:36
PureTech Health doses first patient in BUOY-1 study
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News

seekingalpha
8.5
04-11seekingalpha
Seaport Therapeutics Files for IPO to Develop Neuropsychiatric Drugs
  • IPO Filing Submitted: Seaport Therapeutics (SPTX) has filed for an initial public offering with the SEC, aiming to list on the Nasdaq under the symbol 'SPTX', marking a significant step for the company in terms of financing and market expansion.
  • Funding Utilization: The proceeds from the IPO will be allocated to multiple operational activities, particularly for R&D related to its lead asset GlyphAllo, an oral prodrug aimed at treating major depressive disorder, demonstrating the company's commitment to drug development.
  • Clinical Trial Progress: GlyphAllo is currently undergoing a Phase 2 trial named BUOY-1, with topline results expected in H1 2027, which will have a substantial impact on the company's future development and market positioning.
  • Financial Overview: As of December 31, 2025, Seaport reported an accumulated deficit of $114.1 million, with a net loss in 2025 rising approximately 60% year-over-year to $74.9 million, indicating challenges in profitability despite significant R&D potential.
Newsfilter
9.0
04-02Newsfilter
Deupirfenidone Shows Significant Efficacy in Idiopathic Pulmonary Fibrosis
  • Significant Efficacy: In a 26-week clinical trial, deupirfenidone 825 mg TID monotherapy significantly slowed lung function decline in patients with idiopathic pulmonary fibrosis, with an adjusted mean FVC difference of 91 mL (p=0.02), approaching the lung function changes expected in healthy aging, indicating its potential in treatment.
  • Standard Treatment Comparison: This trial is the first industry-sponsored IPF trial to include a current standard-of-care treatment as an active comparator, enhancing the interpretability of efficacy and safety findings and laying a solid foundation for the upcoming Phase 3 SURPASS-IPF trial.
  • Financing Plans: PureTech's subsidiary, Celea Therapeutics, is working to complete financing to initiate the Phase 3 SURPASS-IPF trial in the first half of 2026, aiming to further validate the efficacy of deupirfenidone and push it towards becoming a new standard of care.
  • Drug Exposure and Tolerability: Deupirfenidone 825 mg TID showed approximately 50% greater drug exposure compared to pirfenidone 801 mg TID, yet the incidence of adverse events was similar (85.9% vs 84.1%), demonstrating its ability to enhance efficacy while maintaining good tolerability.
Newsfilter
9.0
04-02Newsfilter
Seaport Therapeutics Announces Positive Clinical Data for GlyphAgo
  • Clinical Trial Success: Seaport Therapeutics reported positive topline data from its GlyphAgo clinical trial, demonstrating a 6.8-fold increase in bioavailability compared to unmodified agomelatine, exceeding the expected 2-fold target, indicating GlyphAgo's potential in treating generalized anxiety disorder (GAD).
  • Good Safety Profile: GlyphAgo exhibited good tolerability across all evaluated doses in the trial, with no serious adverse events or liver-related side effects reported, enhancing its safety profile and potential market acceptance.
  • Follow-up Trial Plans: Based on the trial results, Seaport plans to advance GlyphAgo into two parallel clinical trials, including a Phase 2a trial to assess its potential sleep benefits in GAD patients and a registration-enabling Phase 2b randomized controlled trial, further validating its clinical application.
  • Platform Advantages: GlyphAgo leverages Seaport's Glyph platform to avoid first-pass liver metabolism, enhancing systemic exposure to agomelatine while reducing liver exposure risks, positioning it as a leading treatment option for GAD and addressing unmet market needs.
Newsfilter
9.0
03-25Newsfilter
Seaport Therapeutics Publishes GlyphAllo Clinical Data
  • Clinical Data Release: Seaport Therapeutics published first-in-human clinical and preclinical data for GlyphAllo™ in Science Translational Medicine, marking a significant advancement in depression treatment and potentially offering new therapeutic options for patients.
  • Drug Efficacy Validation: GlyphAllo demonstrated dose-dependent drug levels in healthy volunteers, with a single 375 mg dose significantly reducing salivary cortisol levels (p=0.0001), indicating its potential in alleviating acute physiological stress responses.
  • Clinical Trial Progress: The development of GlyphAllo has advanced to a global randomized double-blind Phase 2b clinical trial, aimed at evaluating its efficacy, safety, and tolerability in patients with major depressive disorder, further enhancing its market prospects.
  • Platform Technology Advantage: The successful application of the Glyph platform not only improved GlyphAllo's bioavailability but also showcased its broad applicability beyond neuropsychiatry, potentially leading to new therapeutic solutions in oncology, immunology, and metabolic diseases.
Businesswire
1.0
02-25Businesswire
PureTech Health to Participate in Healthcare Conference
  • Executive Participation: PureTech Health's CEO Robert Lyne and Co-founder Eric Elenko will participate in the Leerink Partners Global Healthcare Conference on March 11, 2026, showcasing the company's innovations in biotherapeutics.
  • Webcast Availability: The presentation will be available via webcast on PureTech Health's investor website, ensuring that investors and the public can access the latest updates in real-time.
  • Company Strategy Overview: PureTech Health is dedicated to developing therapeutics through a capital-efficient R&D model, having successfully launched three products approved by the U.S. FDA, demonstrating its potential in the biotherapeutics sector.
  • Cautionary Forward-Looking Statements: The press release includes forward-looking statements, highlighting the risks and uncertainties that may affect the company's future plans and strategies, advising investors to consider relevant risk factors.
Businesswire
9.0
02-19Businesswire
PureTech Secures Orphan Drug Designation for Deupirfenidone in IPF Treatment
  • Orphan Drug Designation: PureTech Health announced that its deupirfenidone (LYT-100) has received Orphan Drug Designation from both the FDA and European Commission for treating idiopathic pulmonary fibrosis (IPF), highlighting the drug's potential to address significant unmet medical needs in this rare disease.
  • Clinical Trial Results: In the global Phase 2b ELEVATE IPF trial, participants receiving deupirfenidone 825 mg three times daily experienced a significantly slower decline in lung function, with a 26-week FVC change of -21.5 mL compared to -112.5 mL for placebo, demonstrating the drug's superior efficacy.
  • Future Research Plans: Celea Therapeutics intends to initiate the Phase 3 SURPASS-IPF trial in the first half of 2026, comparing deupirfenidone to the existing treatment pirfenidone, with successful results potentially providing critical data for drug registration.
  • Broad Market Potential: As a next-generation antifibrotic, deupirfenidone may set a new standard of care for IPF and has potential applications in other fibrotic diseases, further solidifying PureTech's leadership in the biotherapeutics sector.

Valuation Metrics

The current forward P/E ratio for PureTech Health PLC (PRTC.O) is 0.00, compared to its 5-year average forward P/E of -5.35. For a more detailed relative valuation and DCF analysis to assess PureTech Health PLC's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-5.35
Current PE
0.00
Overvalued PE
-3.04
Undervalued PE
-7.66

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-2.95
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
-0.82
Undervalued EV/EBITDA
-5.09

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
63.80
Current PS
0.00
Overvalued PS
114.61
Undervalued PS
13.00

Financials

AI Analysis
Annual
Quarterly

Whales Holding PRTC

T
Tang Capital Management, LLC
Holding
PRTC
+7.80%
3M Return
P
Pentwater Capital Management LP
Holding
PRTC
+3.19%
3M Return
L
Lansdowne Partners Limited
Holding
PRTC
+3.01%
3M Return
I
Interactive Brokers Group, Inc.
Holding
PRTC
-1.23%
3M Return

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Frequently Asked Questions

What is PureTech Health PLC (PRTC) stock price today?

The current price of PRTC is 18.45 USD — it has increased 3.25

What is PureTech Health PLC (PRTC)'s business?

PureTech Health plc is a clinical-stage company dedicated to giving life to new classes of medicine to change the lives of patients with devastating diseases. The Company is engaged in the development of around 29 therapeutics and therapeutic candidates, including three that have been approved by the United States Food and Drug Administration. A number of these programs are advanced by the Company or its Founded Entities in various indications and stages of clinical development. Its primary programs include LYT-100 and LYT-200. Deupirfenidone (LYT-100) is being developed as a potential new standard of care (SOC) for the treatment of idiopathic pulmonary fibrosis (IPF). LYT-200 is an anti-galectin-9 monoclonal antibody (mAb) being developed for the treatment of hematological malignancies, including acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS), as well as solid tumors, including head and neck cancers, with a focus on metastatic disease.

What is the price predicton of PRTC Stock?

Wall Street analysts forecast PRTC stock price to fall over the next 12 months. According to Wall Street analysts, the average 1-year price target for PRTC is USD with a low forecast of USD and a high forecast of USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is PureTech Health PLC (PRTC)'s revenue for the last quarter?

PureTech Health PLC revenue for the last quarter amounts to NaN USD, decreased

What is PureTech Health PLC (PRTC)'s earnings per share (EPS) for the last quarter?

PureTech Health PLC. EPS for the last quarter amounts to USD, decreased

How many employees does PureTech Health PLC (PRTC). have?

PureTech Health PLC (PRTC) has 56 emplpoyees as of April 16 2026.

What is PureTech Health PLC (PRTC) market cap?

Today PRTC has the market capitalization of 444.24M USD.