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PLYX Overview

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Intellectia

Loading chart...

High
7.100
Open
6.350
VWAP
6.63
Vol
86.37K
Mkt Cap
305.84M
Low
6.340
Amount
572.91K
EV/EBITDA(TTM)
--
Total Shares
47.34M
EV
300.57M
EV/OCF(TTM)
--
P/S(TTM)
--
Polaryx Therapeutics, Inc. is a clinical-stage biotechnology company committed to the discovery, development, and commercialization of novel, disease-modifying therapies for rare, pediatric lysosomal storage disorders (LSDs). Its drug candidate pipeline includes PLX-200 (gemfibrozil), PLX-300 (cinnamic acid), PLX-100, and PLX-400. PLX-200 (gemfibrozil), its advanced drug candidate, is an oral small molecule for the treatment of LSDs. PLX-200 is a repurposed drug that the Company is pursuing through a 505(b)(2) regulatory pathway and is designed to be administered through a novel and proprietary oral solution. PLX-300 (cinnamic acid) is a novel, oral small molecule therapy in IND-enabling studies for the treatment of LSDs. PLX-300 is an unsaturated carboxylic acid that occurs naturally in several plants as a deaminated product of phenylalanine. PLX-100 is a preclinical stage orally administrable combination therapy comprised of its PPARa agonist, PLX-200, and vitamin A, a RXRa agonist.
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Events Timeline

(ET)
2026-03-17
08:50:00
Polaryx Receives FDA Fast Track Designation for PLX-200
select
2026-03-12 (ET)
2026-03-12
11:10:00
Polaryx Therapeutics Trading Halted
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2026-02-17 (ET)
2026-02-17
08:40:00
Polaryx Therapeutics Selects CRO for Soteria Clinical Trial
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2026-02-10 (ET)
2026-02-10
08:40:00
Polaryx Therapeutics Presents New Data for PLX-200 at WORLDSymposium
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2026-02-06 (ET)
2026-02-06
10:20:00
Polaryx Therapeutics Trading Halted
select

News

Newsfilter
9.5
04-15Newsfilter
PinnedPolaryx Wins 2026 Pinnacle Award for Pediatric Care Excellence
  • Award Recognition: Polaryx Therapeutics has been honored with the 2026 Pinnacle Award as a Diamond honoree for Excellence in Pediatric Care, highlighting its innovative contributions to the treatment of rare diseases and enhancing its reputation in the biotechnology sector.
  • Platform Approach: The company is advancing a treatment platform that targets shared biological mechanisms such as lysosomal dysfunction and neuroinflammation, thereby improving the efficiency of rare disease treatments and addressing the urgent needs of patients and families, pushing the industry forward.
  • Patient-Centered Options: CEO Alex Yang emphasized that while existing therapies have made progress, significant unmet needs remain; Polaryx is focused on developing effective patient-centered options to alleviate the treatment burden on children and their families, ultimately improving their quality of life.
  • Clinical Trial Initiatives: Polaryx's leading product candidate, PLX-200, is set to launch the SOTERIA Phase 2 trial to evaluate its safety and efficacy, marking a significant advancement in the treatment of rare diseases and potentially offering new hope for patients.
Newsfilter
1.0
04-01Newsfilter
Polaryx to Present Novel Therapies at Needham Conference
  • Conference Participation: Polaryx Therapeutics will participate in the 25th Annual Needham Virtual Healthcare Conference from April 13 to 16, 2026, hosting one-on-one investor meetings to showcase advancements in rare pediatric lysosomal storage disorders, which is expected to attract investor interest and enhance company visibility.
  • Small Molecule Drug Development: The company focuses on developing small molecule and gene therapies to address the underlying pathophysiology of lysosomal storage disorders, particularly its lead candidate PLX-200, which is set to be evaluated in the SOTERIA Phase 2 trial, potentially offering new treatment options for patients.
  • Clinical Trial Plans: Polaryx anticipates initiating clinical development for PLX-200 in the SOTERIA trial, which, if successful, could provide significant therapeutic hope for rare disease patients while also potentially driving stock price appreciation and attracting further investor interest.
  • Investor Relations Enhancement: By conducting group presentations and one-on-one meetings at the conference, Polaryx aims to strengthen communication with investors and enhance transparency, thereby boosting market confidence in its future developments and facilitating further capital inflow.
stocktwits
8.5
03-11stocktwits
Polaryx Therapeutics Shares Surge Post-Listing
  • Significant Price Surge: Polaryx Therapeutics (PLYX) shares soared 70% on Tuesday following its direct listing on February 2, marking its best session ever and attracting heightened interest from retail traders, indicating strong market confidence in the company's potential.
  • Shift in Market Sentiment: Following the stock rally, sentiment on Stocktwits shifted from 'bullish' to 'extremely bullish', with message volume increasing nearly 50%, reflecting strong investor interest and confidence in the biotech firm.
  • Clinical Trial Advancements: Polaryx announced that its PLX-200 treatment has received a 'safe-to-proceed' letter from the FDA and is moving forward with a phase-2 trial for four lysosomal storage disorders, showcasing the company's positive research developments that could underpin future market performance.
  • Surge in Trading Volume: Approximately 25 million shares of PLYX changed hands on Tuesday, about nine times its average trading volume, indicating a significant rise in investor attention that may provide momentum for further price increases.
Newsfilter
8.5
02-27Newsfilter
Polaryx's Commitment to Rare Disease Treatment
  • Trial Launch: Polaryx Therapeutics plans to initiate the SOTERIA clinical trial in the first half of 2026 to evaluate the safety and efficacy of its lead candidate, PLX-200, across four rare lysosomal storage disorders, potentially offering new hope for treatment.
  • Widespread Disease Impact: Rare lysosomal storage disorders affect approximately 1 in 5,000 births, often manifesting in infancy or early childhood, leading to severe clinical outcomes such as developmental regression and premature death, highlighting the urgent need for new therapies.
  • Multi-target Strategy: The SOTERIA trial will simultaneously target four rare diseases, including CLN2, CLN3, Krabbe disease, and Sandhoff disease, with Polaryx estimating that these patient populations represent about one-quarter of the total lysosomal storage disorder population, showcasing its extensive positioning in the rare disease sector.
  • Regulatory Progress: Polaryx received a safe to proceed letter from the FDA in October 2025, marking a significant milestone in its clinical development, which is expected to lay the groundwork for future market access and drug commercialization.
Benzinga
8.5
02-18Benzinga
Polaryx Therapeutics Stock Volatility After Major Clinical Announcement
  • Clinical Trial Milestone: Polaryx Therapeutics has selected a contract research organization for its SOTERIA Phase 2 trial, aimed at evaluating the safety and efficacy of its lead candidate PLX-200 across multiple lysosomal storage disorders, marking a pivotal step towards trial initiation in the first half of 2026.
  • FDA Approval Progress: The company received a safe-to-proceed letter from the FDA in October 2025, and the SOTERIA trial will incorporate natural history data as a control arm, potentially paving the way for conditional marketing authorization based on PLX-200's clinical activity.
  • Stock Price Volatility: Despite a 64.32% surge on Tuesday to $3.96 due to clinical developments, the stock fell 22.47% to $3.07 on Wednesday, reflecting market caution regarding the company's future prospects, with an 88.69% decline over the past 12 months.
  • Market Trend Observation: The current stock price is closer to its 52-week low of $2.20 than its high of $48.91, indicating that Polaryx remains in a bearish trend, prompting investors to monitor the potential impact of clinical trial results on stock performance.
Benzinga
4.5
02-18Benzinga
U.S. Stocks Rise in Morning Trading, Dow Up Approximately 100 Points
  • Market Performance: U.S. stocks opened higher on Wednesday, with the Dow Jones index gaining approximately 100 points, or 0.21%, reaching 49,637.82, indicating positive market sentiment.
  • Sector Dynamics: Energy shares rose by 1.3% on Wednesday, while real estate stocks fell by 0.8%, reflecting a divergence in performance across different sectors.
  • Company Earnings: Analog Devices Inc reported first-quarter earnings of $2.46 per share, exceeding analyst expectations of $2.31, with quarterly sales of $3.16 billion also surpassing the forecast of $3.117 billion, showcasing the company's strong financial performance.
  • Commodity Markets: On Wednesday, oil prices increased by 2.9% to $64.13 per barrel, gold rose by 1.8% to $4,994.30, and silver climbed 5% to $77.235, indicating heightened activity in the commodities market.
Wall Street analysts forecast PLYX stock price to rise
0 Analyst Rating
Wall Street analysts forecast PLYX stock price to rise
0 Buy
0 Hold
0 Sell
Current: 0.000
sliders
Low
Averages
High
Current: 0.000
sliders
Low
Averages
High
Maxim
NULL -> Buy
initiated
$10
AI Analysis
2026-02-27
Reason
Maxim
Price Target
$10
AI Analysis
2026-02-27
initiated
NULL -> Buy
Reason
Maxim initiated coverage of Polaryx with a Buy rating and $10 price target.
Maxim
initiated
$10
2026-02-27
Reason
Maxim
Price Target
$10
2026-02-27
initiated
Reason
As previously reported, Maxim initiated coverage of Polaryx with a Buy rating and $10 price target. The company is aiming to rapidly emerge in the high-value rare disease category through development of PLX-200, a repurposed FDA-approved lipid-lowering drug - LSD - for treatment of lysosomal storage disorders, the analyst tells investors in a research note. The firm views PLX-200 as differentiated given its patient-friendly oral formulation and potential to address a broad spectrum of LSDs by targeting shared disease pathways rather than targeting single gene/enzyme defects, Maxim adds.
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Valuation Metrics

The current forward P/E ratio for Polaryx Therapeutics, Inc (PLYX.O) is 0.00, compared to its 5-year average forward P/E of --. For a more detailed relative valuation and DCF analysis to assess Polaryx Therapeutics, Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
Current PE
0.00
Overvalued PE
Undervalued PE

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
Undervalued EV/EBITDA

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
Current PS
0.00
Overvalued PS
Undervalued PS

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Frequently Asked Questions

What is Polaryx Therapeutics, Inc (PLYX) stock price today?

The current price of PLYX is 6.46 USD — it has decreased -0.15

What is Polaryx Therapeutics, Inc (PLYX)'s business?

Polaryx Therapeutics, Inc. is a clinical-stage biotechnology company committed to the discovery, development, and commercialization of novel, disease-modifying therapies for rare, pediatric lysosomal storage disorders (LSDs). Its drug candidate pipeline includes PLX-200 (gemfibrozil), PLX-300 (cinnamic acid), PLX-100, and PLX-400. PLX-200 (gemfibrozil), its advanced drug candidate, is an oral small molecule for the treatment of LSDs. PLX-200 is a repurposed drug that the Company is pursuing through a 505(b)(2) regulatory pathway and is designed to be administered through a novel and proprietary oral solution. PLX-300 (cinnamic acid) is a novel, oral small molecule therapy in IND-enabling studies for the treatment of LSDs. PLX-300 is an unsaturated carboxylic acid that occurs naturally in several plants as a deaminated product of phenylalanine. PLX-100 is a preclinical stage orally administrable combination therapy comprised of its PPARa agonist, PLX-200, and vitamin A, a RXRa agonist.

What is the price predicton of PLYX Stock?

Wall Street analysts forecast PLYX stock price to fall over the next 12 months. According to Wall Street analysts, the average 1-year price target for PLYX is USD with a low forecast of USD and a high forecast of USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Polaryx Therapeutics, Inc (PLYX)'s revenue for the last quarter?

Polaryx Therapeutics, Inc revenue for the last quarter amounts to -974.00K USD, increased 26.33

What is Polaryx Therapeutics, Inc (PLYX)'s earnings per share (EPS) for the last quarter?

Polaryx Therapeutics, Inc. EPS for the last quarter amounts to USD, decreased

How many employees does Polaryx Therapeutics, Inc (PLYX). have?

Polaryx Therapeutics, Inc (PLYX) has 0 emplpoyees as of April 16 2026.

What is Polaryx Therapeutics, Inc (PLYX) market cap?

Today PLYX has the market capitalization of 305.84M USD.