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PLYX Overview

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Intellectia

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High
7.389
Open
3.290
VWAP
5.55
Vol
25.03M
Mkt Cap
282.64M
Low
3.290
Amount
138.93M
EV/EBITDA(TTM)
--
Total Shares
47.34M
EV
276.89M
EV/OCF(TTM)
--
P/S(TTM)
--

Events Timeline

(ET)
2026-02-17
08:40:00
Polaryx Therapeutics Selects CRO for Soteria Clinical Trial
select
2026-02-10 (ET)
2026-02-10
08:40:00
Polaryx Therapeutics Presents New Data for PLX-200 at WORLDSymposium
select
2026-02-06 (ET)
2026-02-06
10:20:00
Polaryx Therapeutics Trading Halted
select
2026-02-05 (ET)
2026-02-05
15:30:00
Polaryx Therapeutics Trading Halted
select
2026-02-05
08:50:00
Polaryx Therapeutics Appoints New Board Members
select

News

stocktwits
8.5
07:10 AMstocktwits
PinnedPolaryx Therapeutics Shares Surge Post-Listing
  • Significant Price Surge: Polaryx Therapeutics (PLYX) shares soared 70% on Tuesday following its direct listing on February 2, marking its best session ever and attracting heightened interest from retail traders, indicating strong market confidence in the company's potential.
  • Shift in Market Sentiment: Following the stock rally, sentiment on Stocktwits shifted from 'bullish' to 'extremely bullish', with message volume increasing nearly 50%, reflecting strong investor interest and confidence in the biotech firm.
  • Clinical Trial Advancements: Polaryx announced that its PLX-200 treatment has received a 'safe-to-proceed' letter from the FDA and is moving forward with a phase-2 trial for four lysosomal storage disorders, showcasing the company's positive research developments that could underpin future market performance.
  • Surge in Trading Volume: Approximately 25 million shares of PLYX changed hands on Tuesday, about nine times its average trading volume, indicating a significant rise in investor attention that may provide momentum for further price increases.
Newsfilter
8.5
02-27Newsfilter
Polaryx's Commitment to Rare Disease Treatment
  • Trial Launch: Polaryx Therapeutics plans to initiate the SOTERIA clinical trial in the first half of 2026 to evaluate the safety and efficacy of its lead candidate, PLX-200, across four rare lysosomal storage disorders, potentially offering new hope for treatment.
  • Widespread Disease Impact: Rare lysosomal storage disorders affect approximately 1 in 5,000 births, often manifesting in infancy or early childhood, leading to severe clinical outcomes such as developmental regression and premature death, highlighting the urgent need for new therapies.
  • Multi-target Strategy: The SOTERIA trial will simultaneously target four rare diseases, including CLN2, CLN3, Krabbe disease, and Sandhoff disease, with Polaryx estimating that these patient populations represent about one-quarter of the total lysosomal storage disorder population, showcasing its extensive positioning in the rare disease sector.
  • Regulatory Progress: Polaryx received a safe to proceed letter from the FDA in October 2025, marking a significant milestone in its clinical development, which is expected to lay the groundwork for future market access and drug commercialization.
Benzinga
8.5
02-18Benzinga
Polaryx Therapeutics Stock Volatility After Major Clinical Announcement
  • Clinical Trial Milestone: Polaryx Therapeutics has selected a contract research organization for its SOTERIA Phase 2 trial, aimed at evaluating the safety and efficacy of its lead candidate PLX-200 across multiple lysosomal storage disorders, marking a pivotal step towards trial initiation in the first half of 2026.
  • FDA Approval Progress: The company received a safe-to-proceed letter from the FDA in October 2025, and the SOTERIA trial will incorporate natural history data as a control arm, potentially paving the way for conditional marketing authorization based on PLX-200's clinical activity.
  • Stock Price Volatility: Despite a 64.32% surge on Tuesday to $3.96 due to clinical developments, the stock fell 22.47% to $3.07 on Wednesday, reflecting market caution regarding the company's future prospects, with an 88.69% decline over the past 12 months.
  • Market Trend Observation: The current stock price is closer to its 52-week low of $2.20 than its high of $48.91, indicating that Polaryx remains in a bearish trend, prompting investors to monitor the potential impact of clinical trial results on stock performance.
Benzinga
4.5
02-18Benzinga
U.S. Stocks Rise in Morning Trading, Dow Up Approximately 100 Points
  • Market Performance: U.S. stocks opened higher on Wednesday, with the Dow Jones index gaining approximately 100 points, or 0.21%, reaching 49,637.82, indicating positive market sentiment.
  • Sector Dynamics: Energy shares rose by 1.3% on Wednesday, while real estate stocks fell by 0.8%, reflecting a divergence in performance across different sectors.
  • Company Earnings: Analog Devices Inc reported first-quarter earnings of $2.46 per share, exceeding analyst expectations of $2.31, with quarterly sales of $3.16 billion also surpassing the forecast of $3.117 billion, showcasing the company's strong financial performance.
  • Commodity Markets: On Wednesday, oil prices increased by 2.9% to $64.13 per barrel, gold rose by 1.8% to $4,994.30, and silver climbed 5% to $77.235, indicating heightened activity in the commodities market.
Benzinga
8.5
02-17Benzinga
Polaryx Therapeutics Advances Clinical Programs Significantly
  • Clinical Trial Advancement: Polaryx Therapeutics has selected a contract research organization for its SOTERIA Phase 2 trial, aimed at evaluating its lead candidate PLX-200 across multiple lysosomal storage disorders, marking a significant step in the company's clinical development.
  • Innovative Trial Design: The SOTERIA trial employs a flexible and resource-efficient mechanism by comparing natural history data as a control arm against the treated arm of PLX-200, expected to gather crucial data to inform future clinical development pathways.
  • Positive Market Reaction: Following the announcement, Polaryx's shares surged 46.06% to $3.52, reflecting investor optimism regarding the company's clinical progress, although the stock remains near its 52-week low of $2.20.
  • Potential Market Authorization: Should the SOTERIA trial demonstrate compelling clinical activity, PLX-200 could receive conditional marketing authorization, providing significant strategic opportunities for the company's future growth.
Newsfilter
8.5
02-17Newsfilter
Polaryx Selects CRO to Advance PLX-200 Clinical Trial for Rare Disorders
  • Clinical Trial Milestone: Polaryx Therapeutics has selected a leading contract research organization (CRO) to advance the SOTERIA trial, which aims to evaluate the safety and efficacy of its lead candidate PLX-200 across four rare pediatric lysosomal storage disorders, marking a significant milestone in the company's clinical development.
  • FDA Approval Progress: Polaryx received a safe to proceed letter from the FDA in October 2025 and plans to initiate the SOTERIA trial in the first half of 2026, which is expected to provide crucial data for the clinical development of PLX-200 and further enhance its market potential.
  • Drug Characteristics Advantage: PLX-200 is an orally available compound based on the FDA-approved lipid-regulating agent gemfibrozil, which has documented ability to cross the blood-brain barrier, potentially offering effective treatment options for multiple rare diseases and addressing significant unmet medical needs.
  • Trial Design Flexibility: The SOTERIA trial is designed as an open-label, single-arm study that aims to validate the clinical activity of PLX-200 through comparative analyses with natural history data, laying the groundwork for future pivotal trials and demonstrating its resource efficiency and flexibility.
Wall Street analysts forecast PLYX stock price to rise
0 Analyst Rating
Wall Street analysts forecast PLYX stock price to rise
0 Buy
0 Hold
0 Sell
Current: 0.000
sliders
Low
Averages
High
Current: 0.000
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Low
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High
Maxim
NULL -> Buy
initiated
$10
AI Analysis
2026-02-27
Reason
Maxim
Price Target
$10
AI Analysis
2026-02-27
initiated
NULL -> Buy
Reason
Maxim initiated coverage of Polaryx with a Buy rating and $10 price target.
Maxim
initiated
$10
2026-02-27
Reason
Maxim
Price Target
$10
2026-02-27
initiated
Reason
As previously reported, Maxim initiated coverage of Polaryx with a Buy rating and $10 price target. The company is aiming to rapidly emerge in the high-value rare disease category through development of PLX-200, a repurposed FDA-approved lipid-lowering drug - LSD - for treatment of lysosomal storage disorders, the analyst tells investors in a research note. The firm views PLX-200 as differentiated given its patient-friendly oral formulation and potential to address a broad spectrum of LSDs by targeting shared disease pathways rather than targeting single gene/enzyme defects, Maxim adds.
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Valuation Metrics

The current forward P/E ratio for Polaryx Therapeutics, Inc (PLYX.O) is --, compared to its 5-year average forward P/E of --. For a more detailed relative valuation and DCF analysis to assess Polaryx Therapeutics, Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
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Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
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5Y Average EV/EBITDA
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Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
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5Y Average PS
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Frequently Asked Questions

What is Polaryx Therapeutics, Inc (PLYX) stock price today?

The current price of PLYX is 5.97 USD — it has increased 69.6

What is Polaryx Therapeutics, Inc (PLYX)'s business?

What is the price predicton of PLYX Stock?

Wall Street analysts forecast PLYX stock price to fall over the next 12 months. According to Wall Street analysts, the average 1-year price target for PLYX is USD with a low forecast of USD and a high forecast of USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Polaryx Therapeutics, Inc (PLYX)'s revenue for the last quarter?

Polaryx Therapeutics, Inc revenue for the last quarter amounts to -974.00K USD, increased 26.33

What is Polaryx Therapeutics, Inc (PLYX)'s earnings per share (EPS) for the last quarter?

Polaryx Therapeutics, Inc. EPS for the last quarter amounts to USD, decreased

How many employees does Polaryx Therapeutics, Inc (PLYX). have?

Polaryx Therapeutics, Inc (PLYX) has 0 emplpoyees as of March 11 2026.

What is Polaryx Therapeutics, Inc (PLYX) market cap?

Today PLYX has the market capitalization of 282.64M USD.