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OBIO Overview

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Intellectia

Loading chart...

High
4.118
Open
3.990
VWAP
4.02
Vol
197.11K
Mkt Cap
241.92M
Low
3.900
Amount
792.27K
EV/EBITDA(TTM)
--
Total Shares
59.88M
EV
159.48M
EV/OCF(TTM)
--
P/S(TTM)
5.76
Orchestra BioMed Holdings, Inc. is a biomedical innovation company. The Company’s lead product candidates include Atrioventricular Interval Modulation (AVIM) therapy for the treatment of hypertension (HTN), the leading risk factor for death worldwide and the Virtue Sirolimus AngioInfusion Balloon (Virtue SAB) for the treatment of atherosclerotic artery disease, the leading cause of mortality worldwide. The Company develops bioelectronic therapies based on patented Cardiac Neuromodulation Therapy (CNT) technology. The AVIM is a bioelectronic therapy candidate designed to substantially and persistently lower blood pressure. Its Virtue SAB is a proprietary drug/device combination product candidate for the treatment of artery disease that is designed to deliver a proprietary, investigational, extended-release formulation of sirolimus (SirolimusEFR) to the vessel wall during balloon angioplasty without the need for balloon coating or a permanent implant.
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Events Timeline

(ET)
2026-05-06
09:11:00
Orchestra BioMed Receives $15M Payment from Ligand
select
2026-04-30 (ET)
2026-04-30
10:00:00
Orchestra BioMed Receives Second Breakthrough Device Designation from FDA
select
2026-03-12 (ET)
2026-03-12
16:20:00
Major Averages Drop Over 1% Amid Iran War
select
2026-03-12
12:00:00
Markets Volatile Amid Iran War, Oil Prices Surge Over 10%
select
2026-03-12
08:30:00
Orchestra BioMed Reports FY25 Revenue of $33.482M
select
2026-01-12 (ET)
2026-01-12
09:10:00
Orchestra BioMed Expects $21 Million Cash from Vivasure Acquisition
select

News

Newsfilter
9.0
04-30Newsfilter
Orchestra BioMed Secures FDA Breakthrough Device Designation for AVIM Therapy
  • FDA Breakthrough Designation: Orchestra BioMed has received a second Breakthrough Device Designation from the FDA for AVIM Therapy, covering over 7.7 million adults with uncontrolled hypertension despite medication, marking a significant advancement in cardiovascular treatment.
  • Clinical Trial Support: This designation aligns with the ongoing BACKBEAT global pivotal trial aimed at evaluating the safety and efficacy of AVIM Therapy in hypertensive patients, further strengthening the strategic partnership with Medtronic.
  • Reimbursement Pathway Optimization: The Breakthrough Device Designation supports favorable reimbursement pathways, including New Technology Add-on Payment (NTAP) and Transitional Pass-Through (TPT) payments, which will facilitate timely patient access and provider adoption.
  • Significant Market Potential: As a bioelectronic treatment designed to substantially lower blood pressure in hypertensive patients, AVIM Therapy is expected to generate multi-billion-dollar market opportunities for Orchestra BioMed, further solidifying its leadership position in the medical device market.
Newsfilter
8.5
04-23Newsfilter
AVIM Therapy Shows Significant Blood Pressure Reduction
  • Immediate Blood Pressure Reduction: The MODERATO II trial demonstrated that AVIM Therapy activation resulted in an average reduction of 13.2 mmHg in office systolic blood pressure (oSBP), with 97% of patients achieving a reduction greater than 5 mmHg, highlighting its potential in hypertension management.
  • Sustained Control Effects: At the 6-month follow-up, 89% of patients had an ambulatory systolic blood pressure (aSBP) below 140 mmHg, and 58% below 130 mmHg, indicating that AVIM Therapy effectively maintains blood pressure control in line with European and U.S. treatment goals.
  • Long-Term Efficacy Validation: Sustained reductions in blood pressure were observed over 3.6 years in a sub-cohort of patients, further validating the long-term application value of AVIM Therapy, potentially offering new treatment options for high-risk patients.
  • Strategic Collaboration Outlook: Orchestra BioMed's strategic collaboration with Medtronic is ongoing, with the BACKBEAT global pivotal trial set to evaluate the safety and efficacy of AVIM Therapy in uncontrolled hypertension patients, which is expected to create significant market opportunities for the company.
Globenewswire
3.5
2025-12-08Globenewswire
Orchestra BioMed and Medtronic Collaborate on AVIM Therapy Development for Hypertension
  • Strategic Collaboration: Orchestra BioMed's partnership with Medtronic aims to develop AVIM Therapy, which has received FDA Breakthrough Device Designation, potentially offering a new treatment option for 7.7 million U.S. patients with uncontrolled hypertension, significantly enhancing patient quality of life.
  • Clinical Trial Progress: The MODERATO II study demonstrated that AVIM Therapy reduced 24-hour ambulatory systolic blood pressure by an average of 8.1 mmHg over six months, indicating its effectiveness in hypertension management and potentially opening up multi-billion-dollar market opportunities for the company.
  • Innovative Product: The Virtue® Sirolimus AngioInfusion™ Balloon, as the first non-coated drug delivery system, has also received FDA Breakthrough Device Designation, aimed at treating coronary in-stent restenosis, which is expected to transform the treatment landscape for cardiovascular diseases.
  • Market Potential: The successful development of AVIM Therapy and Virtue SAB will position Orchestra BioMed prominently in the global cardiovascular market, particularly in hypertension and atherosclerosis, driving long-term growth for the company.
Newsfilter
3.5
2025-12-08Newsfilter
Orchestra BioMed and Medtronic Collaborate on AVIM Therapy Development
  • Strategic Collaboration Highlight: Orchestra BioMed's partnership with Medtronic aims to develop AVIM Therapy, which has received FDA Breakthrough Device Designation, potentially offering new treatment options for 7.7 million U.S. patients with uncontrolled hypertension, significantly enhancing patient quality of life.
  • Clinical Trial Progress: In the MODERATO II trial, AVIM Therapy demonstrated an average reduction of 8.1 mmHg in 24-hour ambulatory systolic blood pressure over six months, showcasing its efficacy in hypertension management and potentially transforming treatment paradigms.
  • Innovative Product Introduction: Virtue SAB, as the first non-coated drug delivery system, has also received FDA Breakthrough Device Designation for treating coronary in-stent restenosis, highlighting its potential in cardiovascular disease treatment and opening new market opportunities.
  • Industry Impact: The three presentations at the Innovation in Cardiology Intervention meeting in Israel underscore Orchestra BioMed's leadership in biomedical innovation, further solidifying its strategic collaboration with Medtronic and advancing the commercialization of high-impact technologies.
Newsfilter
5.0
2025-11-26Newsfilter
Orchestra BioMed Grants 151,250 Stock Options to 12 New Employees
  • Employee Incentive Program: On November 24, 2025, Orchestra BioMed granted a total of 151,250 stock options to 12 new employees under the 2025 New Hire Inducement Plan, aimed at attracting talent and enhancing the company's competitive edge in the biomedical sector.
  • Vesting Structure: Each new employee will have 25% of their options vest on their first anniversary, with the remainder vesting quarterly over the next three years, which not only incentivizes long-term retention but also enhances team stability and execution capabilities.
  • Strategic Partnership Context: Orchestra BioMed's collaboration with Medtronic, a global medical device leader, accelerates the development of its AVIM therapy, expected to provide innovative solutions for uncontrolled hypertension patients, representing a multi-billion-dollar market opportunity.
  • Product Innovation Outlook: The company's Virtue SAB balloon system has received FDA Breakthrough Device Designation for treating atherosclerotic artery disease, highlighting its significance in the global medical market and the potential to significantly improve patient outcomes.
Newsfilter
1.0
2025-11-11Newsfilter
Orchestra BioMed to Attend Upcoming Conferences for Institutional Investors
  • Upcoming Investor Conferences: Orchestra BioMed will participate in the 2025 Jefferies London Healthcare Conference from November 17-20 and the Piper 37th Annual Healthcare Conference from December 2-4, hosting one-on-one meetings and a live fireside chat.

  • Company Overview: Orchestra BioMed focuses on accelerating high-impact biomedical technologies through partnerships with leading medical device companies, with flagship products AVIM Therapy and Virtue® Sirolimus AngioInfusion™ Balloon currently in pivotal clinical trials.

  • AVIM Therapy Details: AVIM Therapy is a bioelectronic treatment for hypertension, designed to be delivered via a firmware upgrade to pacemakers, and has received FDA Breakthrough Device Designation for patients with uncontrolled hypertension.

  • Virtue SAB Overview: The Virtue SAB is a novel drug delivery angioplasty balloon system aimed at treating atherosclerotic artery disease, also granted Breakthrough Device Designation by the FDA for specific coronary and peripheral artery conditions.

Wall Street analysts forecast OBIO stock price to rise
4 Analyst Rating
Wall Street analysts forecast OBIO stock price to rise
4 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
10.00
Averages
14.25
High
20.00
Current: 0.000
sliders
Low
10.00
Averages
14.25
High
20.00
Barclays
Matt Miksic
maintain
$11 -> $12
AI Analysis
2026-01-09
Reason
Barclays
Matt Miksic
Price Target
$11 -> $12
AI Analysis
2026-01-09
maintain
Reason
Barclays analyst Matt Miksic raised the firm's price target on Orchestra BioMed to $12 from $11 and keeps an Overweight rating on the shares. The firm updated the company's model.
TD Cowen
Joshua Jennings
Buy
initiated
$15
2025-12-10
Reason
TD Cowen
Joshua Jennings
Price Target
$15
2025-12-10
initiated
Buy
Reason
TD Cowen analyst Joshua Jennings initiated coverage of Orchestra BioMed with a Buy rating and $15 price target. Orchestra BioMed is building a differentiated, royalty-based Med Tech model anchored by Atrioventricular Interval Modulation therapy for hypertension and Virtue SAB for arterial atherosclerotic disease, with both programs targeting large, underserved markets, leverage blue-chip partners, and offering scalable, high-margin economics as pivotal data and commercialization milestones approach, the analyst tells investors in a research note. These two assets position Orchestra BioMed at the leading edge of cardiovascular device innovation, the firm argues.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for OBIO
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Valuation Metrics

The current forward P/E ratio for Orchestra Biomed Holdings Inc (OBIO.O) is 0.00, compared to its 5-year average forward P/E of -2.91. For a more detailed relative valuation and DCF analysis to assess Orchestra Biomed Holdings Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-2.91
Current PE
0.00
Overvalued PE
-0.44
Undervalued PE
-5.38

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-2.83
Current EV/EBITDA
445.61
Overvalued EV/EBITDA
84.18
Undervalued EV/EBITDA
-89.84

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
81.11
Current PS
262.28
Overvalued PS
157.07
Undervalued PS
5.14

Financials

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Whales Holding OBIO

M
Medtronic plc
Holding
OBIO
-11.21%
3M Return

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Frequently Asked Questions

What is Orchestra Biomed Holdings Inc (OBIO) stock price today?

The current price of OBIO is 4.04 USD — it has increased 2.8

What is Orchestra Biomed Holdings Inc (OBIO)'s business?

Orchestra BioMed Holdings, Inc. is a biomedical innovation company. The Company’s lead product candidates include Atrioventricular Interval Modulation (AVIM) therapy for the treatment of hypertension (HTN), the leading risk factor for death worldwide and the Virtue Sirolimus AngioInfusion Balloon (Virtue SAB) for the treatment of atherosclerotic artery disease, the leading cause of mortality worldwide. The Company develops bioelectronic therapies based on patented Cardiac Neuromodulation Therapy (CNT) technology. The AVIM is a bioelectronic therapy candidate designed to substantially and persistently lower blood pressure. Its Virtue SAB is a proprietary drug/device combination product candidate for the treatment of artery disease that is designed to deliver a proprietary, investigational, extended-release formulation of sirolimus (SirolimusEFR) to the vessel wall during balloon angioplasty without the need for balloon coating or a permanent implant.

What is the price predicton of OBIO Stock?

Wall Street analysts forecast OBIO stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for OBIO is14.25 USD with a low forecast of 10.00 USD and a high forecast of 20.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Orchestra Biomed Holdings Inc (OBIO)'s revenue for the last quarter?

Orchestra Biomed Holdings Inc revenue for the last quarter amounts to 30.92M USD, increased 12120.16

What is Orchestra Biomed Holdings Inc (OBIO)'s earnings per share (EPS) for the last quarter?

Orchestra Biomed Holdings Inc. EPS for the last quarter amounts to 0.10 USD, decreased -123.81

How many employees does Orchestra Biomed Holdings Inc (OBIO). have?

Orchestra Biomed Holdings Inc (OBIO) has 86 emplpoyees as of May 10 2026.

What is Orchestra Biomed Holdings Inc (OBIO) market cap?

Today OBIO has the market capitalization of 241.92M USD.