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OBIO Overview

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$
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0.000(0.000%)
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0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
4.005
Open
3.990
VWAP
3.94
Vol
193.00K
Mkt Cap
234.13M
Low
3.890
Amount
759.45K
EV/EBITDA(TTM)
--
Total Shares
59.88M
EV
168.03M
EV/OCF(TTM)
--
P/S(TTM)
6.55
Orchestra BioMed Holdings, Inc. is a biomedical innovation company. The Company’s lead product candidates include Atrioventricular Interval Modulation (AVIM) therapy for the treatment of hypertension (HTN), the leading risk factor for death worldwide and the Virtue Sirolimus AngioInfusion Balloon (Virtue SAB) for the treatment of atherosclerotic artery disease, the leading cause of mortality worldwide. The Company develops bioelectronic therapies based on patented Cardiac Neuromodulation Therapy (CNT) technology. The AVIM is a bioelectronic therapy candidate designed to substantially and persistently lower blood pressure. Its Virtue SAB is a proprietary drug/device combination product candidate for the treatment of artery disease that is designed to deliver a proprietary, investigational, extended-release formulation of sirolimus (SirolimusEFR) to the vessel wall during balloon angioplasty without the need for balloon coating or a permanent implant.
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Events Timeline

(ET)
2026-05-12
16:30:00
Orchestra BioMed Reports Q1 Revenue of $110,000
select
2026-05-06 (ET)
2026-05-06
09:11:00
Orchestra BioMed Receives $15M Payment from Ligand
select
2026-04-30 (ET)
2026-04-30
10:00:00
Orchestra BioMed Receives Second Breakthrough Device Designation from FDA
select
2026-03-12 (ET)
2026-03-12
16:20:00
Major Averages Drop Over 1% Amid Iran War
select
2026-03-12
12:00:00
Markets Volatile Amid Iran War, Oil Prices Surge Over 10%
select
2026-03-12
08:30:00
Orchestra BioMed Reports FY25 Revenue of $33.482M
select

News

seekingalpha
9.5
05-12seekingalpha
Orchestra BioMed Reports Q1 Earnings with Mixed Results
  • Earnings Performance: Orchestra BioMed's Q1 GAAP EPS of -$0.33 exceeded expectations by $0.10, yet revenue of $0.11M fell short by $0.05M, reflecting significant challenges in revenue growth with an 87.4% year-over-year decline.
  • Cash Position: As of March 31, 2026, the company reported cash and cash equivalents totaling $94.4 million, indicating a relatively stable liquidity position, although future capital efficiency remains a concern.
  • Funding Developments: On May 1, 2026, the company secured $35 million, including $20 million from Medtronic and $15 million from Ligand, which will support operational and R&D activities despite the overall revenue weakness.
  • Historical Performance Comparison: Orchestra BioMed's previous GAAP EPS was -$1.11 with revenue of $33.48M, highlighting significant performance volatility over the past year and reflecting uncertainties and challenges in market competition.
Newsfilter
2.0
05-12Newsfilter
Orchestra BioMed Updates BACKBEAT Trial Timeline
  • Trial Enrollment Target: Orchestra BioMed aims to complete enrollment for the BACKBEAT trial by the end of Q3 2026, targeting 316 patients to ensure data validity and reliability, thereby laying the groundwork for subsequent FDA approval.
  • Data Submission Plan: The company and Medtronic plan to submit primary endpoint data to a major cardiology conference in Q2 2027, which, if successful, will provide strong clinical evidence for the market launch of AVIM Therapy.
  • Sample Size Adjustment: The FDA approved a reduction in the trial sample size to 284 evaluable randomized subjects, ensuring the ability to detect at least a 5 mmHg difference in systolic blood pressure at the 3-month follow-up, enhancing the trial's statistical power.
  • Strategic Collaboration Outlook: The partnership between Orchestra BioMed and Medtronic aims to promote AVIM Therapy for hypertension patients, which, if successful, could offer new treatment options for millions of patients globally, representing significant market potential.
Newsfilter
9.0
04-30Newsfilter
Orchestra BioMed Secures FDA Breakthrough Device Designation for AVIM Therapy
  • FDA Breakthrough Designation: Orchestra BioMed has received a second Breakthrough Device Designation from the FDA for AVIM Therapy, covering over 7.7 million adults with uncontrolled hypertension despite medication, marking a significant advancement in cardiovascular treatment.
  • Clinical Trial Support: This designation aligns with the ongoing BACKBEAT global pivotal trial aimed at evaluating the safety and efficacy of AVIM Therapy in hypertensive patients, further strengthening the strategic partnership with Medtronic.
  • Reimbursement Pathway Optimization: The Breakthrough Device Designation supports favorable reimbursement pathways, including New Technology Add-on Payment (NTAP) and Transitional Pass-Through (TPT) payments, which will facilitate timely patient access and provider adoption.
  • Significant Market Potential: As a bioelectronic treatment designed to substantially lower blood pressure in hypertensive patients, AVIM Therapy is expected to generate multi-billion-dollar market opportunities for Orchestra BioMed, further solidifying its leadership position in the medical device market.
Newsfilter
8.5
04-23Newsfilter
AVIM Therapy Shows Significant Blood Pressure Reduction
  • Immediate Blood Pressure Reduction: The MODERATO II trial demonstrated that AVIM Therapy activation resulted in an average reduction of 13.2 mmHg in office systolic blood pressure (oSBP), with 97% of patients achieving a reduction greater than 5 mmHg, highlighting its potential in hypertension management.
  • Sustained Control Effects: At the 6-month follow-up, 89% of patients had an ambulatory systolic blood pressure (aSBP) below 140 mmHg, and 58% below 130 mmHg, indicating that AVIM Therapy effectively maintains blood pressure control in line with European and U.S. treatment goals.
  • Long-Term Efficacy Validation: Sustained reductions in blood pressure were observed over 3.6 years in a sub-cohort of patients, further validating the long-term application value of AVIM Therapy, potentially offering new treatment options for high-risk patients.
  • Strategic Collaboration Outlook: Orchestra BioMed's strategic collaboration with Medtronic is ongoing, with the BACKBEAT global pivotal trial set to evaluate the safety and efficacy of AVIM Therapy in uncontrolled hypertension patients, which is expected to create significant market opportunities for the company.
Globenewswire
3.5
2025-12-08Globenewswire
Orchestra BioMed and Medtronic Collaborate on AVIM Therapy Development for Hypertension
  • Strategic Collaboration: Orchestra BioMed's partnership with Medtronic aims to develop AVIM Therapy, which has received FDA Breakthrough Device Designation, potentially offering a new treatment option for 7.7 million U.S. patients with uncontrolled hypertension, significantly enhancing patient quality of life.
  • Clinical Trial Progress: The MODERATO II study demonstrated that AVIM Therapy reduced 24-hour ambulatory systolic blood pressure by an average of 8.1 mmHg over six months, indicating its effectiveness in hypertension management and potentially opening up multi-billion-dollar market opportunities for the company.
  • Innovative Product: The Virtue® Sirolimus AngioInfusion™ Balloon, as the first non-coated drug delivery system, has also received FDA Breakthrough Device Designation, aimed at treating coronary in-stent restenosis, which is expected to transform the treatment landscape for cardiovascular diseases.
  • Market Potential: The successful development of AVIM Therapy and Virtue SAB will position Orchestra BioMed prominently in the global cardiovascular market, particularly in hypertension and atherosclerosis, driving long-term growth for the company.
Newsfilter
3.5
2025-12-08Newsfilter
Orchestra BioMed and Medtronic Collaborate on AVIM Therapy Development
  • Strategic Collaboration Highlight: Orchestra BioMed's partnership with Medtronic aims to develop AVIM Therapy, which has received FDA Breakthrough Device Designation, potentially offering new treatment options for 7.7 million U.S. patients with uncontrolled hypertension, significantly enhancing patient quality of life.
  • Clinical Trial Progress: In the MODERATO II trial, AVIM Therapy demonstrated an average reduction of 8.1 mmHg in 24-hour ambulatory systolic blood pressure over six months, showcasing its efficacy in hypertension management and potentially transforming treatment paradigms.
  • Innovative Product Introduction: Virtue SAB, as the first non-coated drug delivery system, has also received FDA Breakthrough Device Designation for treating coronary in-stent restenosis, highlighting its potential in cardiovascular disease treatment and opening new market opportunities.
  • Industry Impact: The three presentations at the Innovation in Cardiology Intervention meeting in Israel underscore Orchestra BioMed's leadership in biomedical innovation, further solidifying its strategic collaboration with Medtronic and advancing the commercialization of high-impact technologies.
Wall Street analysts forecast OBIO stock price to rise
4 Analyst Rating
Wall Street analysts forecast OBIO stock price to rise
4 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
10.00
Averages
14.25
High
20.00
Current: 0.000
sliders
Low
10.00
Averages
14.25
High
20.00
B. Riley
B. Riley
Buy
downgrade
$12 -> $10
AI Analysis
2026-05-19
Reason
B. Riley
B. Riley
Price Target
$12 -> $10
AI Analysis
2026-05-19
downgrade
Buy
Reason
B. Riley lowered the firm's price target on Orchestra BioMed (OBIO) to $10 from $12 and keeps a Buy rating on the shares. Orchestra BioMed reported Q1 results alongside key regulatory and trial updates for its BACKBEAT program, including FDA approval of a reduced Phase 3 sample size, continued targeting of enrollment completion by Q3 and primary endpoint data in 2Q27, while also securing $35M in committed strategic capital and receiving a second Breakthrough Device Designation, the analyst tells investors in a research note. The clarified PMA pathway with its partner Medtronic (MDT) supports a more de-risked regulatory timeline and potential royalty-driven commercialization beginning in 2028, the firm says.
Barclays
Matt Miksic
maintain
$12 -> $13
2026-05-13
Reason
Barclays
Matt Miksic
Price Target
$12 -> $13
2026-05-13
maintain
Reason
Barclays analyst Matt Miksic raised the firm's price target on Orchestra BioMed to $13 from $12 and keeps an Overweight rating on the shares. The company's better than expected Q1 report included a positive update on the BACKBEAT pivotal trial, the analyst tells investors in a research note.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for OBIO
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Valuation Metrics

The current forward P/E ratio for Orchestra Biomed Holdings Inc (OBIO.O) is 0.00, compared to its 5-year average forward P/E of -2.95. For a more detailed relative valuation and DCF analysis to assess Orchestra Biomed Holdings Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-2.95
Current PE
0.00
Overvalued PE
-0.48
Undervalued PE
-5.41

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-1.69
Current EV/EBITDA
-1.60
Overvalued EV/EBITDA
88.31
Undervalued EV/EBITDA
-91.69

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
86.22
Current PS
360.48
Overvalued PS
167.61
Undervalued PS
4.84

Financials

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Whales Holding OBIO

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Holding
OBIO
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Frequently Asked Questions

What is Orchestra Biomed Holdings Inc (OBIO) stock price today?

The current price of OBIO is 3.91 USD — it has decreased -1.76

What is Orchestra Biomed Holdings Inc (OBIO)'s business?

Orchestra BioMed Holdings, Inc. is a biomedical innovation company. The Company’s lead product candidates include Atrioventricular Interval Modulation (AVIM) therapy for the treatment of hypertension (HTN), the leading risk factor for death worldwide and the Virtue Sirolimus AngioInfusion Balloon (Virtue SAB) for the treatment of atherosclerotic artery disease, the leading cause of mortality worldwide. The Company develops bioelectronic therapies based on patented Cardiac Neuromodulation Therapy (CNT) technology. The AVIM is a bioelectronic therapy candidate designed to substantially and persistently lower blood pressure. Its Virtue SAB is a proprietary drug/device combination product candidate for the treatment of artery disease that is designed to deliver a proprietary, investigational, extended-release formulation of sirolimus (SirolimusEFR) to the vessel wall during balloon angioplasty without the need for balloon coating or a permanent implant.

What is the price predicton of OBIO Stock?

Wall Street analysts forecast OBIO stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for OBIO is14.25 USD with a low forecast of 10.00 USD and a high forecast of 20.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Orchestra Biomed Holdings Inc (OBIO)'s revenue for the last quarter?

Orchestra Biomed Holdings Inc revenue for the last quarter amounts to 110.00K USD, decreased -87.33

What is Orchestra Biomed Holdings Inc (OBIO)'s earnings per share (EPS) for the last quarter?

Orchestra Biomed Holdings Inc. EPS for the last quarter amounts to -0.33 USD, decreased -32.65

How many employees does Orchestra Biomed Holdings Inc (OBIO). have?

Orchestra Biomed Holdings Inc (OBIO) has 86 emplpoyees as of May 31 2026.

What is Orchestra Biomed Holdings Inc (OBIO) market cap?

Today OBIO has the market capitalization of 234.13M USD.