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LYEL Should I Buy

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Intellectia

Should You Buy Lyell Immunopharma Inc (LYEL) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Hold
Latest Price
23.700
1 Day change
-0.59%
52 Week Range
45.000
Analysis Updated At
2026/04/17
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Lyell Immunopharma Inc (LYEL) is not a strong buy at the moment for a beginner investor with a long-term focus. While the technical indicators show some bullish momentum, the company's financial performance is weak, with significant declines in revenue, net income, and EPS. Additionally, there are no recent positive news catalysts or significant trading trends to support immediate investment. Analysts have a positive outlook with high price targets, but the lack of strong proprietary trading signals and the absence of recent congress or influential trading data suggest a cautious approach. Holding off for now is recommended.

Technical Analysis

The MACD is positive at 0.444, indicating bullish momentum, but it is contracting. RSI is neutral at 59.639. Moving averages are bullish (SMA_5 > SMA_20 > SMA_200). Key resistance levels are R1: 24.751 and R2: 26.042, while support levels are S1: 20.572 and S2: 19.281.

Options Data

Bullish
Open Interest Put-Call Ratio
Bullish
Option Volume Put-Call Ratio

Technical Summary

StrongSellSellNeutralBuyStrongBuydotted line Image
Sell
1
Buy
9

Positive Catalysts

  • and a positive outlook on the company's lead product, ronde-cel, in the CAR-T therapy space. The stock has bullish moving averages and a positive MACD.

Neutral/Negative Catalysts

  • The company's financial performance in Q4 2025 shows significant declines in revenue (-45.45% YoY), net income (-26.68% YoY), and EPS (-49.96% YoY). No recent news or significant trading trends from hedge funds, insiders, or congress. The stock has a low probability of significant short-term gains based on historical candlestick patterns.

Financial Performance

In Q4 2025, revenue dropped by 45.45% YoY to 6000. Net income decreased by 26.68% YoY to -140,723,000, and EPS fell by 49.96% YoY to -6.86. Gross margin remained stable at 100%.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

Analysts have a positive outlook with Buy and Outperform ratings. Price targets range from $34 to $44, with the potential for significant upside in a bull case scenario.

Wall Street analysts forecast LYEL stock price to rise
2 Analyst Rating
Wall Street analysts forecast LYEL stock price to rise
1 Buy
0 Hold
1 Sell
Hold
Current: 23.840
sliders
Low
12
Averages
28.5
High
45
Current: 23.840
sliders
Low
12
Averages
28.5
High
45
Needham
initiated
$44
AI Analysis
2026-04-10
Reason
Needham
Price Target
$44
AI Analysis
2026-04-10
initiated
Reason
Needham initiated coverage of Lyell Immunopharma with a Buy rating and $44 price target. The firm says the company's ronde-cel is in the "pole position" for second-line diffuse large B-cell lymphoma. Lyell's "bold head-to-head development strategy" has the potential to make ronde-cel the CAR-T of choice in second-line DLBCL, the analyst tells investors in a research note. Needham views the company as an "under-the-radar name with undervalued assets."
Lucid Capital
Christopher Liu
Buy
maintain
$32 -> $39
2026-03-13
Reason
Lucid Capital
Christopher Liu
Price Target
$32 -> $39
2026-03-13
maintain
Buy
Reason
Lucid Capital analyst Christopher Liu raised the firm's price target on Lyell Immunopharma to $39 from $32 and keeps a Buy rating on the shares following the fiscal 2025 results. The cites lower estimated dilutive financing this year for the target increase.
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