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LONA Overview

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0.000
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0.000(0.000%)Aft-market
ET
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0.000
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ET
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Intellectia

Loading chart...

High
9.790
Open
8.900
VWAP
9.41
Vol
125.93K
Mkt Cap
90.37M
Low
8.760
Amount
1.19M
EV/EBITDA(TTM)
--
Total Shares
9.34M
EV
913.64K
EV/OCF(TTM)
--
P/S(TTM)
--
LeonaBio, Inc., formerly Athira Pharma, Inc., is a clinical-stage biopharmaceutical company dedicated to the development of novel therapeutics for diseases with high unmet medical needs, including treatment-resistant metastatic breast cancer and amyotrophic lateral sclerosis (ALS). The Company's lead drug candidates, lasofoxifene and ATH-1105, are novel, small molecule therapies with the potential to address devastating diseases where current treatment options are limited or ineffective. ATH-1105 is a novel, orally available, brain-penetrant, next-generation small-molecule drug candidate designed to positively modulate the neurotrophic HGF system for potential treatment of neurodegenerative diseases, including ALS, Alzheimer's disease, and Parkinson's disease. Lasofoxifene is a novel, nonsteroidal SERM with a binding profile, designed to confer potent activity against both wild-type and mutant estrogen receptors, including the clinically significant ESR1 mutations.
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Events Timeline

(ET)
2026-02-03
07:10:00
LeonaBio Appoints Mark Kubik as Chief Business Officer
select
2026-01-20 (ET)
2026-01-20
16:50:00
LeonaBio Files to Sell 5.5M Shares of Common Stock
select

News

seekingalpha
9.5
10:11 AMseekingalpha
PinnedLeonaBio Reports FY 2025 Financial Results
  • Earnings Loss: LeonaBio reported a GAAP EPS of -$24.70 for FY 2025, indicating significant challenges in profitability that could negatively impact investor confidence and stock performance.
  • Improved Cash Position: As of December 31, 2025, the company's cash, cash equivalents, and investments totaled $88.3 million, a substantial increase from $51.3 million in 2024, suggesting enhanced financial management and increased operational flexibility for future endeavors.
  • Reduced Operating Cash Flow: The net cash used in operations for FY 2025 was $45.7 million, a significant decrease from $97.2 million in 2024, reflecting progress in cost control and operational efficiency, potentially laying the groundwork for future profitability.
  • Corporate Restructuring: LeonaBio is undergoing a name and ticker symbol change, a strategic move aimed at rebranding and attracting new investors, thereby enhancing market competitiveness and shareholder value.
moomoo
9.0
03-26moomoo
PinnedLEONABIO INC ANTICIPATES COMPLETION OF PHASE 3 LASOFOXIFENE TRIAL ENROLLMENT BY Q4 2026, WITH TOPLINE RESULTS EXPECTED IN SECOND HALF OF 2027
  • Phase 3 Trial Expectations: Leonabiol is anticipating the completion of Phase 3 trials for its product by the second quarter of 2026.
  • Topline Data Release: The company plans to release topline data from the trials in the second half of 2027.
Newsfilter
8.5
03-26Newsfilter
LeonaBio Secures License for Lasofoxifene Development Program
  • Successful Financing: LeonaBio secured $90 million in private placement financing, with cash-exercisable warrants potentially providing an additional $146 million, which will robustly support the development of Lasofoxifene through key clinical and regulatory milestones, ensuring financial stability for the company.
  • Clinical Trial Progress: The company expects to complete enrollment for the Phase 3 clinical trial of Lasofoxifene by Q4 2026, with topline data anticipated in the second half of 2027, offering a new treatment option for patients with ER-positive, HER2-negative, ESR1-mutated metastatic breast cancer, which holds significant market potential.
  • Drug Development Strategy: As a novel selective estrogen receptor modulator, Lasofoxifene aims to target ESR1 mutations in metastatic breast cancer patients, potentially becoming the preferred second-line treatment and altering the standard of care in this field, enhancing the company's competitive position in the biopharmaceutical market.
  • New Drug Candidate ATH-1105: LeonaBio plans to initiate a Phase 2 proof-of-concept study for ATH-1105 in ALS patients in the second half of 2026, demonstrating the company's diversified strategy and innovative capabilities in the neurodegenerative disease sector.
moomoo
4.0
02-19moomoo
LEONABIO INC: MIZUHO UPGRADES RATING TO OUTPERFORM AND INCREASES TARGET PRICE TO $10 FROM $4
  • Company Performance: Leonabi Inc. has reported a significant improvement in its performance, indicating positive growth and operational efficiency.

  • Target Price Increase: The company's target price has been raised to $10 from a previous $4, reflecting increased investor confidence and market expectations.

Wall Street analysts forecast LONA stock price to rise
0 Analyst Rating
Wall Street analysts forecast LONA stock price to rise
0 Buy
0 Hold
0 Sell
Current: 0.000
sliders
Low
Averages
High
Current: 0.000
sliders
Low
Averages
High
Cantor Fitzgerald
Overweight
initiated
$15
AI Analysis
2026-02-26
Reason
Cantor Fitzgerald
Price Target
$15
AI Analysis
2026-02-26
initiated
Overweight
Reason
Cantor Fitzgerald initiated coverage of LeonaBio with an Overweight rating and no price target. The company's lasofoxifene has been re-purposed for the treatment of ER+ metastatic breast cancer patients with ESR1 mutations and is "very potent against such mutations," the analyst tells investors in a research note. Cantor's valuation analysis features a 60% probability of success, which suggests LeonaBio shares might be more fairly valued at $15, contends the firm.
Mizuho
Neutral
to
Outperform
upgrade
$10
2026-02-18
Reason
Mizuho
Price Target
$10
2026-02-18
upgrade
Neutral
to
Outperform
Reason
Mizuho upgraded LeonaBio to Outperform from Neutral with a $10 price target, which implies 120% upside potential. The firm upgraded the shares after introducing projections for LeonaBio's new lead asset lasofoxifene in mutated ESR1/mESR1+ metastatic breast cancer and ATH-1105 for amyotrophic lateral sclerosis. Current investor awareness of LeonaBio "is quite low" following the company's recent rebranding, the analyst tells investors in a research note. Mizuho sees that changing into the company's Phase 3 data for lasofoxifene expected in mid-2027.
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Valuation Metrics

The current forward P/E ratio for LeonaBio Inc (LONA.O) is --, compared to its 5-year average forward P/E of --. For a more detailed relative valuation and DCF analysis to assess LeonaBio Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PE
Current PE
NaN
Overvalued PE
Undervalued PE

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average EV/EBITDA
Current EV/EBITDA
NaN
Overvalued EV/EBITDA
Undervalued EV/EBITDA

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
Current PS
NaN
Overvalued PS
Undervalued PS

Financials

AI Analysis
Annual
Quarterly

Whales Holding LONA

C
Commodore Capital LP
Holding
LONA
+15.47%
3M Return
T
TCG Crossover Management, LLC
Holding
LONA
-0.62%
3M Return
N
New Enterprise Associates, Inc.
Holding
LONA
-4.10%
3M Return

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Frequently Asked Questions

What is LeonaBio Inc (LONA) stock price today?

The current price of LONA is 9.68 USD — it has increased 7.2

What is LeonaBio Inc (LONA)'s business?

LeonaBio, Inc., formerly Athira Pharma, Inc., is a clinical-stage biopharmaceutical company dedicated to the development of novel therapeutics for diseases with high unmet medical needs, including treatment-resistant metastatic breast cancer and amyotrophic lateral sclerosis (ALS). The Company's lead drug candidates, lasofoxifene and ATH-1105, are novel, small molecule therapies with the potential to address devastating diseases where current treatment options are limited or ineffective. ATH-1105 is a novel, orally available, brain-penetrant, next-generation small-molecule drug candidate designed to positively modulate the neurotrophic HGF system for potential treatment of neurodegenerative diseases, including ALS, Alzheimer's disease, and Parkinson's disease. Lasofoxifene is a novel, nonsteroidal SERM with a binding profile, designed to confer potent activity against both wild-type and mutant estrogen receptors, including the clinically significant ESR1 mutations.

What is the price predicton of LONA Stock?

Wall Street analysts forecast LONA stock price to fall over the next 12 months. According to Wall Street analysts, the average 1-year price target for LONA is USD with a low forecast of USD and a high forecast of USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is LeonaBio Inc (LONA)'s revenue for the last quarter?

LeonaBio Inc revenue for the last quarter amounts to -6.87M USD, decreased -73.04

What is LeonaBio Inc (LONA)'s earnings per share (EPS) for the last quarter?

LeonaBio Inc. EPS for the last quarter amounts to -4668000.00 USD, decreased -79.72

How many employees does LeonaBio Inc (LONA). have?

LeonaBio Inc (LONA) has 26 emplpoyees as of March 27 2026.

What is LeonaBio Inc (LONA) market cap?

Today LONA has the market capitalization of 90.37M USD.