INKT

Earnings Reports Overview: Several companies, including Spire Inc., Scholar Rock Holding Corporation, and Twist Bioscience Corporation, are set to report their earnings for the quarter ending September 30, 2025, with varying forecasts for earnings per share (EPS) and growth compared to the previous year.

Spire Inc. Performance: Spire Inc. is expected to report an EPS of $-0.46, reflecting a 14.81% increase year-over-year, with a Price to Earnings (P/E) ratio of 20.08, indicating stronger growth potential than its industry peers.

Scholar Rock Holding Corporation and Twist Bioscience: Scholar Rock is forecasted to have an EPS of $-0.88, a 33.33% decrease from last year, while Twist Bioscience anticipates an EPS of $-0.40, a 32.20% increase, despite missing previous earnings expectations.

Other Notable Companies: Companies like Bit Digital, Sigma Lithium, and SBC Medical Group are also reporting, with SBC Medical expected to show significant growth with a 333.33% increase in EPS, while others like MiNK Therapeutics and Mersana Therapeutics are facing declines in their EPS forecasts.

Clinical Results of agenT-797: MiNK Therapeutics reported promising clinical results for agenT-797, showing durable survival and deep remissions in patients with advanced solid tumors resistant to checkpoint inhibitors, with a median overall survival of approximately 23 months.

Immune Activation and Tumor Remodeling: The therapy demonstrated immune reprogramming within the tumor microenvironment, enhancing immune responses and restoring the immune system's ability to recognize and attack tumors, even in cases of profound treatment resistance.

Safety and Efficacy Profile: agenT-797 exhibited a favorable safety profile with manageable side effects, supporting its potential for combination therapies and repeat-dose regimens in future studies.

Potential Impact on Cancer Treatment: The findings position agenT-797 as a first-in-class iNKT cell therapy that could transform treatment for patients with refractory solid tumors, bridging innate and adaptive immunity to extend the benefits of immunotherapy.