HYFT News & Events

MindWalk Holdings "announced B Cell Llama(TM), a platform for the discovery of VHH nanobodies: the single-domain antibody fragments increasingly recognized as the ideal molecular building blocks for bispecific antibodies, multispecific therapeutics, and CAR-T cell therapies. Bispecific antibody sales alone are projected to reach US$50 billion by 2030, with the broader cell therapy market adding tens of billions more. B Cell Llama is designed to help partners capture this opportunity with better starting material and AI-guided precision at every step of the discovery process. The announcement is anchored by a study published in Biomacromolecules (American Chemical Society, 2026), conducted by MindWalk in a grant-funded collaboration with Eindhoven University of Technology and Radboud University Medical Center. Three findings from the study illustrate what modular VHH design can achieve: Potency amplified through assembly. Nanobodies displayed in multivalent formats achieved sub-nanomolar potency, 10 to 25 times greater than the same nanobody in monovalent form; Modular reconfiguration defeats resistance. A trivalent VHH construct neutralized variants that escaped all monovalent formats and defeated a pair of approved antibody therapies, demonstrating that rational reassembly of the same building block can restore activity where single agents fail; A potential immune-priming effect. VHH-nanoparticle complexes were preferentially internalized by immune cells associated with long-term immune memory, raising the possibility that certain VHH formats may not only neutralize a target but help the immune system recognize it in the future. The study also produced a finding with direct relevance to AI-guided drug discovery: the molecule with the strongest binding affinity delivered zero functional activity. Binding strength is not a reliable proxy for efficacy. Some conventional discovery workflows depend heavily on binding metrics to rank and select candidates. LensAI(TM) is designed to prioritize function directly."

MindWalk announced an advance in its universal influenza program following the identification of a functional constraint that persists across influenza viruses despite continual evolution. MindWalk identified a functional pattern embedded in influenza biology that remains intact beneath surface-level genetic change. When MindWalk examines what does not change, it is not referring to conserved genetic sequences. It refers to preserved biological constraints; the biophysical requirements influenza must satisfy for infection.

MindWalk announced the results of its 2025 annual general meeting. In accordance with the company's majority voting policy, Kamil Isaev, having received approximately 32% of votes in favor and 68% withheld for his re-election, has tendered his resignation to the board. The board has accepted the resignation, effective immediately, and is initiating a search process to fill the vacancy.

MindWalk announced the appointment of industry veteran R. Scott Areglado as CFO, effective October 20. Areglado brings more than 25 years of financial leadership experience across the healthcare, life sciences, and technology sectors. He most recently served as CFO of BrainsWay and before that was CFO at iCAD.