GNTA News & Events

Genenta Science announced that it has entered into a binding offer with Sophia High Tech, under which Genenta will fund Sophia through two reserved capital increases, with the goal of reaching a controlling stake upon the achievement of defined performance milestones. The transaction with Sophia High Tech would be completed in two phases and remains subject to confirmatory due diligence, required approvals, and definitive transaction documentation. Sophia High Tech is an aerospace and defense engineering and manufacturing company, headquartered in Somma Vesuviana, Italy. Genenta expects to fund a total of EUR 6M in two tranches, the second tranche being performance-driven. Sophia High Tech is projecting growing revenues. Sophia HT is already profitable and forecasts continued EBITDA growth in 2026, 2027 and beyond. The funds are expected to be used for materially scaling production capacity, accelerating technological differentiation, and strengthening commercial penetration.

Genenta Science announced that, with respect to its biotechnology platform, Genenta has been and continues to be actively engaged with DC Advisory to explore potential collaboration opportunities for the further development of its original biotechnology platform, which originated from research conducted by founder-scientists, Professor Luigi Naldini and Bernhard Gentner. To date, DC Advisory has not identified, and the company is not in any active discussions with, potential strategic partners regarding Temferon or its biotechnology platform. Genenta nevertheless intends to continue pursuing potential collaboration opportunities. "As a co-founder, I have never sold my shares in Genenta; in fact, I have increased my position by purchasing ADSs during open trading windows," said Pierluigi Paracchi, CEO of Genenta. "The founder-scientists are currently holders of Genenta's ordinary shares and Genenta opposes any sale of shares by the founder-scientists unless and until Temferon receives meaningful third-party validation. Given the current uncertainty surrounding the future development of Temferon, the founder-scientists have been aware of Genenta's need to broaden its strategic path, even if they have not fully shared that view. We are building Genenta into an industrial aggregator operating in some of the most strategically sensitive sectors of the modern economy - biotech, defense, aerospace, and cybersecurity. Think of us as a forge: we identify the most promising scale-ups in sectors that matter for national security, and we provide them with capital, structure, indirect access to the U.S. public markets through our Nasdaq listing, and the industrial capabilities needed to help them become national champions. We are pursuing this strategy not in spite of the market, but ahead of it. Italy produces extraordinary technology and industrial value. Too often, however, it fails to retain them. We believe that this value creation should remain here. Above all, this strategic evolution is intended to serve the best interests of our shareholders, and we remain fully focused on creating long-term shareholder value through disciplined execution and the selective acquisition of high-quality industrial assets."

Genenta Science intends to target majority ownership in companies with established operating profitability, typically generating up to approximately EUR 5M in EBITDA. In this context, Genenta plans to adopt the new corporate name of Saentra Forge with a new Nasdaq ticker symbol of (SAEN). Saentra Forge intends to pursue a strategy by acquiring targets at private-market valuations and integrating these companies under Saentra Forge. Through this integration, the company will seek to enhance these businesses through operational upgrades, institutional-grade governance, and improved financial visibility. Execution has commenced with ATC, a defense-sector company. Genenta has entered into a binding agreement according to which it will provide funding for ATC through a series of reserved capital increases, via a performance-based and staged acquisition to support operations with the ultimate goal of owning a controlling position in ATC upon the achievement of defined performance milestones. The transaction has received the required clearance under the Golden Power regulatory framework. ATC holds UAMA and SeRNI export-control licenses, NATO qualifications, and authorization from the Italian Ministry of Defense, and its platforms are used by special-forces units and include combat-proven systems. Genenta expects to fund a total of EUR 5.1M in several performance-driven tranches. ATC is projecting revenues of approximately EUR 4M in 2026, increasing to around EUR 9M by 2027. The company operates with a solid net cash position and no outstanding bank debt, reflecting a disciplined management structure. On the profitability side, ATC forecasts EBITDA of more than EUR 2M in 2026, with management expecting EBITDA to approximately double in 2027. In addition, ATC anticipates closing 2026 with a cash balance exceeding EUR 2M, and expects to further strengthen its liquidity position by ending 2027 with cash exceeding EUR 5M. At the core of the company's strategic configuration is the Praexidia Foundation, which has become a shareholder. The Praexidia Foundation is a private law foundation bringing together figures from Italian government institutions, the defense industry, and the armed forces. The company, the foundation, and Pierluigi Paracchi, founder and CEO, have entered into a shareholders' agreement that provides for consultation rights on corporate transactions and a renewable five-year lock-up. The company expects its cash, cash equivalents, and marketable securities at December 31, 2025, to be approximately $33M, compared to $17.7M at June 30, 2025. The increase is primarily due to the company's registered direct offering with certain institutional investors.

Genenta Science announced an update from its ongoing TEM-GBM study in newly diagnosed glioblastoma multiforme patients with an unmethylated MGMT gene promoter. As of the November 21, data cut, 25 patients have been treated with Temferon. These data are compared to the previously disclosed April 15 cut, communicated on July 1. More than seven months after the prior update, key survival metrics for the TEM-GBM patients remain consistent. In total, 44% of patients have reached 18-month survival, compared to 38% reported in April. Two-year survival rate continues to be 29% and median overall survival remains at 17 months, both consistent with prior findings. For context, historical cohorts of uMGMT patients treated with standard of care typically show a two-year survival rate of approximately 14% and median overall survival of 13-15 months. The study includes the first patient who has reached three years of survival following Temferon administration. During this period, the patient did not receive additional therapeutic interventions or second-line treatments. At the follow-up visit conducted at three years, imaging indicated disease progression and the patient subsequently underwent a second surgery. The patient has continued on protocol-scheduled assessments and has recently completed the 3.5-year follow-up visit within the long-term surveillance study. This patient is also the second in the study who has not required further therapeutic interventions during the reported follow-up, a period that overlaps with the window in which recurrence is commonly observed in GBM. These observations are descriptive only, occur within a disease setting known for heterogeneous clinical courses, and individual patient outcomes may vary. As the first clinical setting in which the platform is being evaluated, the GBM study also provides early immune observations on Temferon's behavior within the tumor microenvironment. These preliminary findings include indications that bone-marrow-derived myeloid cells can reach the tumor site and deliver immunotherapeutic payloads in situ, in a manner that is consistent with the intended design of the platform. While exploratory in nature and subject to further confirmation in larger controlled studies, these observations are helping to inform the broader development of Temferon - including potential combination approaches - and the evolution of the underlying cell-based delivery technology.