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FULC Overview

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$
0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
7.020
Open
7.020
VWAP
6.61
Vol
3.12M
Mkt Cap
427.79M
Low
6.380
Amount
20.62M
EV/EBITDA(TTM)
--
Total Shares
66.63M
EV
127.79M
EV/OCF(TTM)
--
P/S(TTM)
--
Fulcrum Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases in areas of high unmet medical need. The Company's lead clinical program is pociredir, a small molecule designed to increase expression of fetal hemoglobin for the treatment of sickle cell disease (SCD). It uses technology to identify drug targets that can modulate gene expression to treat the known root cause of gene mis-expression. In addition to its product candidates, the Company has developed a discovery approach that it employs to systematically identify and validate cellular drug targets that can potentially modulate gene expression to treat known root causes of genetically defined rare diseases. The Company continues to advance its program for the potential treatment of inherited aplastic anemias, such as Diamond-Blackfan anemia (DBA), Shwachman-Diamond syndrome, and Fanconi anemia.
Show More

Events Timeline

(ET)
2026-06-01
16:20:00
Fulcrum Discontinues Pociredir Program and Reviews Strategic Alternatives
select

News

stocktwits
8.5
06-01stocktwits
PinnedFulcrum Discontinues pociredir Development, Shares Plunge 49%
  • Regulatory Feedback Impact: On May 28, Fulcrum received meeting minutes from the FDA indicating serious concerns about the benefit-risk profile of pociredir, leading to the decision to discontinue its development, resulting in the loss of its only clinical asset and leaving the company without a near-term pipeline, severely impacting future business prospects.
  • Stock Price Volatility: Following the announcement of the discontinuation, Fulcrum's shares plummeted 49% in after-hours trading, reflecting extreme market pessimism regarding the company's outlook, which could lead to further capital erosion and investor confidence issues.
  • Strategic Review Initiated: Fulcrum has launched a comprehensive strategic review to explore alternatives, including mergers and acquisitions, aimed at maximizing shareholder value, demonstrating the company's response strategy amid significant challenges, though no specific timeline has been set, increasing uncertainty.
  • Market Sentiment Shift: Despite the stock price decline, retail sentiment around Fulcrum on Stocktwits shifted from 'bearish' to 'bullish', with message volume rising from 'low' to 'normal', indicating some investors' optimism about potential future transactions, although overall market sentiment remains cautious.
NASDAQ.COM
2.0
13:04 PMNASDAQ.COM
Biotech Stocks Show Strong Pre-Market Moves
  • Bluejay Diagnostics Surge: Bluejay Diagnostics, Inc. (BJDX) skyrocketed 193% to $6.35 in pre-market trading, indicating strong market demand for its products, which may attract more investor interest in its future developments.
  • Picard Medical Significant Growth: Picard Medical, Inc. (PMI) saw a 95% increase to $0.33, reflecting positive investor sentiment towards its new products or services, potentially providing the company with additional funding support.
  • Sunshine Biopharma Continues Upward Trend: Sunshine Biopharma, Inc. (SBFM) rose 26% to $3.00 in pre-market trading, suggesting optimistic market sentiment regarding its R&D progress, which could facilitate an expansion of its market share.
  • Fulcrum Therapeutics Major Decline: Fulcrum Therapeutics, Inc. (FULC) plummeted 52% to $3.06 in pre-market trading, indicating investor concerns about its financial health, which may limit its ability to secure future financing.
Newsfilter
2.0
11:41 AMNewsfilter
Fulcrum Therapeutics Abandons Sickle-Cell Drug Development Amid FDA Concerns
  • Stock Plunge: Fulcrum Therapeutics' shares plummeted 50% in premarket trading on Tuesday, reflecting strong market reaction to the company's decision to abandon its experimental sickle-cell disease drug following FDA cancer risk concerns, leading to a significant loss of investor confidence.
  • Drug Development Setback: The company aimed to use pociredir to increase fetal hemoglobin levels for treating sickle-cell disease, but the FDA indicated that all drugs targeting the PRC2 protein complex carry similar malignancy risks, compounding the challenges in drug development.
  • Strategic Shift: Fulcrum announced it would explore strategic options, including a potential sale or merger, and has begun cost-cutting measures to preserve cash, with current cash and investments totaling $333.3 million, indicating the company's response strategy amid significant challenges.
  • Clinical Trial Insights: Despite the FDA's safety concerns, Fulcrum emphasized that no new safety issues had emerged in clinical trials, and pociredir demonstrated increases in fetal hemoglobin, which could help alleviate disease severity in sickle-cell patients.
seekingalpha
7.5
11:11 AMseekingalpha
Fulcrum Therapeutics Halts pociredir Development Amid FDA Safety Concerns
  • Development Halted: Fulcrum Therapeutics announced the discontinuation of its lead asset pociredir for sickle cell disease due to safety concerns raised by the FDA, resulting in a nearly 50% drop in stock value during after-hours trading.
  • Regulatory Feedback Impact: The FDA highlighted an unfavorable benefit-risk profile for pociredir during a recent meeting, particularly in light of blood cancer risks associated with Tazverik, leaving no viable regulatory path for further clinical development.
  • Strategic Review Initiated: Concurrently, the company announced a strategic alternatives review program, including a potential sale, to address current financial pressures and plans to sharply cut operating expenditures to preserve capital amid uncertainty.
  • CEO Statement: CEO Alex Sapir stated that after a thorough review of regulatory feedback and available data, the difficult decision to halt pociredir's development reflects significant implications for the company's future trajectory.
NASDAQ.COM
8.5
07:04 AMNASDAQ.COM
Fulcrum Discontinues Pociredir Program Amid FDA Concerns
  • Program Termination: Fulcrum Therapeutics announced the discontinuation of its lead program Pociredir due to FDA feedback regarding concerns over secondary malignancies associated with Tazverik, leading to significant challenges in the company's R&D efforts and a complete withdrawal from the global market.
  • Stock Plunge: Following the announcement, Fulcrum's stock plummeted 51.25% to $3.13 in after-hours trading, reflecting extreme investor pessimism about the company's future prospects, which could adversely affect its ability to raise funds and maintain market confidence.
  • Strategic Review Initiated: Fulcrum stated it will explore strategic alternatives, including mergers, acquisitions, or other strategic transactions, aiming to identify new growth opportunities despite facing significant R&D hurdles, indicating a proactive approach to restore investor confidence through potential restructuring.
  • Financial Position: As of March 31, 2026, Fulcrum had $333.3 million in cash and cash equivalents, providing the company with some financial flexibility to navigate future strategic adjustments despite the pressure from the program termination.
Newsfilter
5.0
05-08Newsfilter
Fulcrum Therapeutics Grants Stock Options to New Employees
  • Stock Option Grant: Fulcrum Therapeutics granted 55,500 stock options to two new employees at an exercise price of $7.02 per share, reflecting the company's commitment to attracting talent to enhance its research and development capabilities.
  • Incentive Plan Context: This grant is made under the company's 2022 Inducement Stock Incentive Plan, complying with Nasdaq Listing Rule 5635(c)(4), demonstrating Fulcrum's strategic planning in talent acquisition to boost overall competitiveness.
  • Option Structure Design: The options have a ten-year term with a four-year vesting schedule, where 25% vests on the first anniversary and 6.25% vests quarterly thereafter, which not only incentivizes long-term employee retention but also ensures team stability to support ongoing business growth.
  • Company Strategic Positioning: Fulcrum focuses on developing small molecules to improve the lives of patients with rare genetic diseases, particularly targeting sickle cell disease, showcasing the company's innovative capabilities and market potential in the biopharmaceutical sector, thereby reinforcing its industry position.
Wall Street analysts forecast FULC stock price to rise
11 Analyst Rating
Wall Street analysts forecast FULC stock price to rise
9 Buy
1 Hold
1 Sell
Moderate Buy
Current: 0.000
sliders
Low
7.00
Averages
16.80
High
25.00
Current: 0.000
sliders
Low
7.00
Averages
16.80
High
25.00
Leerink
Outperform
to
Market Perform
downgrade
$24 -> $4
AI Analysis
2026-06-02
New
Reason
Leerink
Price Target
$24 -> $4
AI Analysis
2026-06-02
New
downgrade
Outperform
to
Market Perform
Reason
Leerink downgraded Fulcrum Therapeutics to Market Perform from Outperform with a price target of $4, down from $24, after the company announced the discontinuation of the pociredir program in sickle cell disease, driven primarily by FDA's concerns surrounding the broader polycomb repressive complex 2 inhibitor class and the potential risk of secondary malignancies. While "surprised by this outcome," the firm sees limited visibility into future value creation beyond strategic alternatives and cost-cutting initiatives, the analyst tells investors.
Leerink
Outperform
to
Market Perform
downgrade
$4
2026-06-02
New
Reason
Leerink
Price Target
$4
2026-06-02
New
downgrade
Outperform
to
Market Perform
Reason
Leerink downgraded Fulcrum Therapeutics to Market Perform from Outperform with a $4 price target.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for FULC
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Valuation Metrics

The current forward P/E ratio for Fulcrum Therapeutics Inc (FULC.O) is 0.00, compared to its 5-year average forward P/E of -6.30. For a more detailed relative valuation and DCF analysis to assess Fulcrum Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-6.30
Current PE
0.00
Overvalued PE
1.51
Undervalued PE
-14.11

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-2.65
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.80
Undervalued EV/EBITDA
-6.11

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
49.69
Current PS
0.00
Overvalued PS
117.74
Undervalued PS
-18.36

Financials

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Whales Holding FULC

B
Braidwell LP
Holding
FULC
+12.38%
3M Return
T
TCG Crossover Management, LLC
Holding
FULC
+12.01%
3M Return
S
Suvretta Capital Management, LLC
Holding
FULC
+11.96%
3M Return
N
Nantahala Capital Management, LLC
Holding
FULC
+9.14%
3M Return
A
Artal Group S.A.
Holding
FULC
+6.99%
3M Return
V
Vestal Point Capital, LP
Holding
FULC
+4.84%
3M Return

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Frequently Asked Questions

What is Fulcrum Therapeutics Inc (FULC) stock price today?

The current price of FULC is 6.42 USD — it has decreased -7.23

What is Fulcrum Therapeutics Inc (FULC)'s business?

Fulcrum Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases in areas of high unmet medical need. The Company's lead clinical program is pociredir, a small molecule designed to increase expression of fetal hemoglobin for the treatment of sickle cell disease (SCD). It uses technology to identify drug targets that can modulate gene expression to treat the known root cause of gene mis-expression. In addition to its product candidates, the Company has developed a discovery approach that it employs to systematically identify and validate cellular drug targets that can potentially modulate gene expression to treat known root causes of genetically defined rare diseases. The Company continues to advance its program for the potential treatment of inherited aplastic anemias, such as Diamond-Blackfan anemia (DBA), Shwachman-Diamond syndrome, and Fanconi anemia.

What is the price predicton of FULC Stock?

Wall Street analysts forecast FULC stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for FULC is16.80 USD with a low forecast of 7.00 USD and a high forecast of 25.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Fulcrum Therapeutics Inc (FULC)'s revenue for the last quarter?

Fulcrum Therapeutics Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Fulcrum Therapeutics Inc (FULC)'s earnings per share (EPS) for the last quarter?

Fulcrum Therapeutics Inc. EPS for the last quarter amounts to -0.25 USD, decreased -10.71

How many employees does Fulcrum Therapeutics Inc (FULC). have?

Fulcrum Therapeutics Inc (FULC) has 55 emplpoyees as of June 02 2026.

What is Fulcrum Therapeutics Inc (FULC) market cap?

Today FULC has the market capitalization of 427.79M USD.