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FULC Overview

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ET
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0.000
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Intellectia

Loading chart...

High
8.070
Open
7.940
VWAP
7.78
Vol
1.06M
Mkt Cap
518.82M
Low
7.490
Amount
8.24M
EV/EBITDA(TTM)
--
Total Shares
66.60M
EV
166.51M
EV/OCF(TTM)
--
P/S(TTM)
--
Fulcrum Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases in areas of high unmet medical need. The Company's lead clinical program is pociredir, a small molecule designed to increase expression of fetal hemoglobin for the treatment of sickle cell disease (SCD). It uses technology to identify drug targets that can modulate gene expression to treat the known root cause of gene mis-expression. In addition to its product candidates, the Company has developed a discovery approach that it employs to systematically identify and validate cellular drug targets that can potentially modulate gene expression to treat known root causes of genetically defined rare diseases. The Company continues to advance its program for the potential treatment of inherited aplastic anemias, such as Diamond-Blackfan anemia (DBA), Shwachman-Diamond syndrome, and Fanconi anemia.
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Events Timeline

(ET)
2026-02-24
07:20:00
Fulcrum Therapeutics Reports Positive Results from PIONEER Trial
select
2026-02-24
07:20:00
Fulcrum CEO Says pociredir Has Great Potential in Sickle Cell Disease Treatment
select
2025-12-10 (ET)
2025-12-10
08:00:00
JPMorgan Increases Deal Size to $175M
select

News

Newsfilter
5.0
03-06Newsfilter
Fulcrum Therapeutics Grants Stock Options to New Employee
  • Stock Option Grant: Fulcrum Therapeutics granted 34,000 stock options to a new employee at an exercise price of $7.81 per share, reflecting the closing price on March 2, 2026, aimed at attracting talent and strengthening the company's team.
  • Incentive Plan Context: This grant is made under Fulcrum's 2022 Inducement Stock Incentive Plan, complying with Nasdaq Listing Rule 5635(c)(4), demonstrating the company's commitment to attracting and retaining key talent.
  • Option Structure: The options have a ten-year term and vest over four years, with 25% vesting on the first anniversary and an additional 6.25% vesting quarterly, ensuring continued employee contribution during their tenure with the company.
  • Company Mission: Fulcrum focuses on developing small molecules to improve the lives of patients with genetically defined rare diseases, with its lead clinical program pociredir aimed at increasing fetal hemoglobin expression to treat sickle cell disease, highlighting the company's strategic positioning in areas of high unmet medical need.
NASDAQ.COM
8.5
02-27NASDAQ.COM
Significant Milestones in Biotech Sector This Week
  • FDA Drug Approvals: Armata Pharmaceuticals' AP-SA02 received FDA's QIDP designation, granting five years of market exclusivity and paving the way for a Phase 3 trial in 2026, which is expected to significantly enhance the company's competitive edge in the antibiotic market.
  • Weight Loss Innovation: Allurion Technologies' gastric balloon system gained FDA approval, offering a non-surgical weight loss option for patients with a BMI of 30-40, which is anticipated to expand the company's market share in the obesity sector.
  • Acquisition Deal: Gilead Sciences is acquiring Arcellx for $115 per share, totaling $7.8 billion, a move that will strengthen Gilead's position in cell therapy and enhance its collaboration with Kite Pharma.
  • Clinical Trial Developments: Novo Nordisk's CagriSema missed key goals in its trial against Zepbound, although it demonstrated a favorable safety profile, which may influence future market strategies.
Benzinga
9.0
02-24Benzinga
Fulcrum Therapeutics Reports Phase 1b Trial Results Amid Stock Decline
  • Clinical Trial Results: Fulcrum Therapeutics reported that in its Phase 1b trial for pociredir, the 20 mg cohort showed a 12.2% increase in mean absolute fetal hemoglobin (HbF) at 12 weeks, significantly outperforming the 8.6% increase in the 12 mg cohort, indicating the drug's potential in enhancing HbF levels.
  • Safety Analysis: The trial reported no serious adverse events, although one patient discontinued due to an unrelated Grade 5 serious adverse event; overall, the strong safety profile could support future registration trials.
  • Future Plans: Fulcrum intends to initiate a potential registration-enabling trial in the second half of 2026 and plans to engage with the European Medicines Agency in mid-2026 for feedback on the next trial design, demonstrating a proactive approach to development.
  • Financial Position: As of 2025, Fulcrum had $352.3 million in cash and cash equivalents, projected to sustain operations through 2029, despite a 10.01% drop in stock price following the latest announcement, reflecting market caution regarding trial outcomes.
seekingalpha
8.5
02-24seekingalpha
Fulcrum Therapeutics Reports Q4 Earnings and Cash Position
  • Earnings Report: Fulcrum Therapeutics reported a Q4 GAAP EPS of -$0.31, aligning with market expectations, indicating stability in financial management despite ongoing losses.
  • Strong Cash Position: As of 2025, Fulcrum's cash, cash equivalents, and marketable securities totaled $352.3 million, providing a cash runway into 2029, which ensures operational stability for the coming years.
  • Capital Raising Strategy: The company announced the pricing of a $175 million upsized public offering of common stock and pre-funded warrants, reflecting an active approach to fundraising aimed at supporting its R&D and operational needs.
  • Clinical Trial Updates: Fulcrum presented new clinical data from the Phase 1b PIONEER trial at the 44th Annual J.P. Morgan Healthcare Conference, highlighting its ongoing innovation and potential in the treatment of sickle cell disease.
Newsfilter
5.0
02-06Newsfilter
Fulcrum Therapeutics Grants Stock Options to New Employee
  • Stock Options Granted: Fulcrum Therapeutics granted 70,000 stock options to a new employee at an exercise price of $10.72 per share, reflecting the company's commitment to attracting talent and strengthening its team to drive research and development efforts.
  • Incentive Plan Context: The grant is made under the amended 2022 Inducement Stock Incentive Plan, complying with Nasdaq Listing Rule 5635(c)(4), which demonstrates the company's adherence to compliance and transparency in talent acquisition.
  • Options Structure: These options have a ten-year term and vest over four years, with 25% vesting on the first anniversary and an additional 6.25% vesting quarterly, designed to incentivize long-term employee retention and enhance engagement.
  • Strategic Company Positioning: Fulcrum focuses on developing small molecules to improve the lives of patients with genetically defined rare diseases, particularly its lead program pociredir for sickle cell disease, showcasing the company's strategic positioning in areas of high unmet medical need.
Benzinga
6.0
01-12Benzinga
BMO Initiates Medline Coverage with $45 Price Target
  • Medline Coverage Initiation: BMO Capital analyst Sean Dodge initiated coverage on Medline Inc (NASDAQ:MDLN) with an Outperform rating and a price target of $45, indicating an approximate 11% upside from the current share price of $40.52, reflecting confidence in the company's growth prospects.
  • Hims & Hers Rating Update: Evercore ISI Group analyst Mark Mahaney initiated coverage on Hims & Hers Health Inc (NYSE:HIMS) with an In-Line rating and a price target of $33, suggesting a stable growth outlook as the current share price stands at $31.69.
  • Andersen Group Coverage Initiation: UBS analyst Kevin Mcveigh initiated coverage on Andersen Group Inc (NYSE:ANDG) with a Buy rating and a price target of $28, indicating significant upside potential from the current price of $24.29, reflecting optimism about its market performance.
  • Netflix Rating Update: HSBC analyst Mohammed Khallouf initiated coverage on Netflix Inc (NASDAQ:NFLX) with a Buy rating and a price target of $107, suggesting an approximate 19% upside from the current share price of $89.44, indicating confidence in its content strategy and market position.
Wall Street analysts forecast FULC stock price to rise
11 Analyst Rating
Wall Street analysts forecast FULC stock price to rise
9 Buy
1 Hold
1 Sell
Moderate Buy
Current: 0.000
sliders
Low
7.00
Averages
16.80
High
25.00
Current: 0.000
sliders
Low
7.00
Averages
16.80
High
25.00
Truist
Buy
maintain
$18
AI Analysis
2026-02-24
Reason
Truist
Price Target
$18
AI Analysis
2026-02-24
maintain
Buy
Reason
After Fulcrum Therapeutics disclosed full Cohort 4 data from the Phase Ib PIONEER study for pociredir in sickle cell disease, Truist notes that mean absolute HbF was 19.3% and treatment delta was 12%, striking management's anticipated outcomes. "Encouragingly," oral pociredir continues to show a consistent safety and tolerability profile, adds the analyst, who would remain buyers of shares on any weakness and maintains a Buy rating and $18 price target on the "under-the-radar story."
Stifel
James Condulis
Buy
maintain
$25
2026-02-24
Reason
Stifel
James Condulis
Price Target
$25
2026-02-24
maintain
Buy
Reason
Stifel analyst James Condulis tells investors that the move lower in Fulcrum Therapeutics this morning "surprises us" and looks "overdone." While the firm believes some thought total mean HbF may comfortably be greater than 20% given the strength of the initial cut at ASH, the firm thinks "overly nitpicking 19.3% is splitting hairs and misses the bigger picture" as these data surpassed the physician "bar" and that pociredir is reaching HbF levels expected to be highly protective of disease. Even with a rebound this morning, shares significantly discount a soon-to-be late-stage asset with a validated mechanism of action in the white-space sickle cell disease market, argues the analyst, who has a Buy rating and $25 price target on Fulcrum shares.
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Valuation Metrics

The current forward P/E ratio for Fulcrum Therapeutics Inc (FULC.O) is -9.06, compared to its 5-year average forward P/E of -6.19. For a more detailed relative valuation and DCF analysis to assess Fulcrum Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-6.19
Current PE
-9.06
Overvalued PE
1.44
Undervalued PE
-13.83

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-2.64
Current EV/EBITDA
-5.74
Overvalued EV/EBITDA
0.73
Undervalued EV/EBITDA
-6.02

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
48.73
Current PS
0.00
Overvalued PS
115.29
Undervalued PS
-17.84

Financials

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Whales Holding FULC

A
Artal Group S.A.
Holding
FULC
+7.65%
3M Return
V
Vestal Point Capital, LP
Holding
FULC
+6.42%
3M Return
T
TCG Crossover Management, LLC
Holding
FULC
+2.13%
3M Return
S
Suvretta Capital Management, LLC
Holding
FULC
+1.43%
3M Return
R
RA Capital Management, L.P.
Holding
FULC
+1.17%
3M Return
B
Braidwell LP
Holding
FULC
+0.39%
3M Return

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Frequently Asked Questions

What is Fulcrum Therapeutics Inc (FULC) stock price today?

The current price of FULC is 7.79 USD — it has decreased -2.75

What is Fulcrum Therapeutics Inc (FULC)'s business?

Fulcrum Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases in areas of high unmet medical need. The Company's lead clinical program is pociredir, a small molecule designed to increase expression of fetal hemoglobin for the treatment of sickle cell disease (SCD). It uses technology to identify drug targets that can modulate gene expression to treat the known root cause of gene mis-expression. In addition to its product candidates, the Company has developed a discovery approach that it employs to systematically identify and validate cellular drug targets that can potentially modulate gene expression to treat known root causes of genetically defined rare diseases. The Company continues to advance its program for the potential treatment of inherited aplastic anemias, such as Diamond-Blackfan anemia (DBA), Shwachman-Diamond syndrome, and Fanconi anemia.

What is the price predicton of FULC Stock?

Wall Street analysts forecast FULC stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for FULC is16.80 USD with a low forecast of 7.00 USD and a high forecast of 25.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Fulcrum Therapeutics Inc (FULC)'s revenue for the last quarter?

Fulcrum Therapeutics Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Fulcrum Therapeutics Inc (FULC)'s earnings per share (EPS) for the last quarter?

Fulcrum Therapeutics Inc. EPS for the last quarter amounts to -0.31 USD, increased 14.81

How many employees does Fulcrum Therapeutics Inc (FULC). have?

Fulcrum Therapeutics Inc (FULC) has 55 emplpoyees as of March 12 2026.

What is Fulcrum Therapeutics Inc (FULC) market cap?

Today FULC has the market capitalization of 518.82M USD.