What’s Behind the 75% Surge in Phio Pharmaceuticals Stock Today?
Stock Rally: Phio Pharmaceuticals (PHIO) stock surged 76.59% in pre-market trading after announcing positive results from a Phase 1b trial of its INTASYL gene-silencing technology aimed at treating cancer.
Clinical Trial Results: The trial showed significant cancer elimination in three patients with cutaneous squamous cell carcinoma, with one patient achieving 100% elimination and others showing 90% and 50% reductions.
CEO Statement: Robert Bitterman, CEO of Phio Pharmaceuticals, highlighted the trial's outcomes as a promising step towards a non-surgical treatment alternative for cutaneous carcinomas.
Analyst Ratings: Wall Street analysts have a consensus rating of Moderate Buy for PHIO, with a price target of $14, indicating a potential upside of nearly 583% for the stock.
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Phio Pharmaceuticals Initiates Toxicology Study for PH-762, Aiming for 2026 Market Launch
- Critical Research Initiation: Phio Pharmaceuticals has commenced a toxicology study for PH-762, a crucial step mandated by the FDA that aims to pave the way for human pivotal trials, thereby accelerating the drug development process and enhancing market competitiveness.
- Clear Commercialization Goals: The company plans to launch a commercially viable product that meets FDA current Good Manufacturing Practices by 2026, a target supported by recent financing, demonstrating Phio's proactive response to market demands.
- Clinical Trial Progress: In the ongoing Phase 1b trial, 6 out of 18 skin cancer patients achieved 100% tumor clearance, indicating PH-762's potential as a non-surgical treatment option for skin cancers, which could significantly impact treatment paradigms.
- Strengthened Strategic Partnerships: Phio has entered into a comprehensive drug substance development services agreement with a U.S. manufacturing company, ensuring that clinical supplies for PH-762 meet cGMP standards, which will enhance production capabilities and expedite the product's market entry.
Three Penny Stocks to Keep an Eye on as of November 4, 2025
Penny Stocks to Watch: Generation Essentials Group, Phio Pharmaceuticals, and Caribou Biosciences are highlighted as top penny stocks to monitor on November 4, 2025, based on their high Dollar Volume and market activity.
Generation Essentials Group: This France-based media company saw a Dollar Volume of $308 million and a 123% stock price increase after announcing a share repurchase program and plans to acquire hotels globally.
Phio Pharmaceuticals: The biotech firm experienced a Dollar Volume of $301.44 million despite a 9.3% decline in stock price, following positive trial results for its cancer treatment, which initially surged by nearly 75%.
Caribou Biosciences: With a Dollar Volume of $166.10 million, Caribou's stock reached a 52-week high after positive analyst ratings and promising data on its CRISPR gene-editing therapies for difficult-to-treat cancers.
