TransCode's TTX-MC138 Set to Begin Phase 2a Trial Within Quantum Leap PRE-I-SPY Initiative
Collaboration Announcement: TransCode Therapeutics and Quantum Leap Healthcare Collaborative are collaborating to evaluate TTX-MC138 in a Phase 2a dose-expansion trial, following positive results from a Phase 1 study.
Therapeutic Candidate Details: TTX-MC138 is designed to inhibit microRNA-10b, a biomarker associated with metastatic cancers, and has shown safety and a recommended dose in its initial trials.
Phase 2a Study Plans: The upcoming Phase 2a study will involve up to 45 colorectal cancer patients with minimal residual disease, aiming to assess the drug's biological and clinical activity in this critical treatment setting.
Market Reaction: Following the announcement, TransCode's stock rose by 20.74% to $10.42 but experienced a decline in pre-market trading, dropping to $9.92.
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TransCode Publishes TTX-MC138 Research for Glioblastoma Treatment
- Research Publication: TransCode Therapeutics, in collaboration with Michigan State University, published preclinical research on TTX-MC138 for glioblastoma treatment, demonstrating significant survival improvements, marking a crucial advancement in addressing treatment-resistant cancers.
- Efficacy Validation: The study showed that TTX-MC138 effectively delivered to human glioblastoma in murine models, inducing a five-fold increase in apoptotic activity, further validating its potential to overcome drug delivery barriers.
- Clinical Trial Progress: TTX-MC138 has completed IND studies and toxicity testing, showing good safety in Phase I trials for non-CNS cancers, with a Phase II trial anticipated to begin in the first half of 2026, advancing its clinical application.
- Strategic Implications: This research not only provides robust biological support for TransCode's RNA therapeutic platform but also showcases its broad potential in treating metastatic tumors, potentially transforming the treatment landscape for glioblastoma.

TransCode's TTX-MC138 Significantly Extends Survival in Glioblastoma Mouse Models
- Survival Extension: TTX-MC138 successfully delivered via intravenous injection in glioblastoma mouse models significantly extends survival, indicating its potential in treating this highly aggressive cancer.
- Target Mechanism Validation: The study demonstrates that TTX-MC138 effectively suppresses miR-10b, resulting in a five-fold increase in apoptotic activity in tumors, thereby enhancing therapeutic efficacy and supporting its clinical development.
- Preclinical Research Findings: Conducted in collaboration with Michigan State University and published in the Journal of Functional Biomaterials, this study lays the groundwork for the clinical application of TTX-MC138, which is expected to drive future clinical trials.
- Future Clinical Trial Plans: Currently undergoing Phase 1 clinical trials, TTX-MC138 is anticipated to enter Phase 2 trials in the first half of 2026, further validating its potential application in metastatic diseases.









