TransCode and Quantum Leap Collaborate to Evaluate TTX-MC138
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 11 2025
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TransCode Therapeutics and Quantum Leap Healthcare Collaborative announce a new collaboration to evaluate TransCode's therapeutic candidate TTX-MC138 as part of the Quantum Leap PRE-I-SPY clinical trial platform. The PRE-I-SPY program will incorporate TTX-MC138 in a Phase 2a dose-expansion clinical trial enrolling up to 45 patients with colorectal cancer who have completed standard curative-intent therapy and are ctDNA positive. The Phase 2a portion of the trial is planned to begin in the first half of 2026 and will be led by Principal Investigator Dr. Paula Pohlmann of MD Anderson Cancer Center.
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About RNAZ
TransCode Therapeutics, Inc. is a clinical-stage oncology company focused on treating metastatic disease. It is defeating cancer through the intelligent design and effective delivery of RNA therapeutics based on its proprietary TTX nanoparticle platform. Its lead candidate, TTX-MC138, targets metastatic tumors overexpressing microRNA-10b, a biomarker of metastasis. The Company is also developing a portfolio of RNA therapeutic candidates to overcome delivery challenges and unlock access to novel genetic targets. Its preclinical programs include TTX-siPDL1 (siRNA modulator of PD-L1), TTX-RIGA (RNA agonist of RIG-I for innate immunity activation), and TTX-siMYC (siRNA inhibitor of c-MYC). Additionally, R&D efforts are exploring the combination of TTX-MC138 and seviprotimut-L technologies to enhance therapeutic impact.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
TransCode Publishes TTX-MC138 Research for Glioblastoma Treatment
- Research Publication: TransCode Therapeutics, in collaboration with Michigan State University, published preclinical research on TTX-MC138 for glioblastoma treatment, demonstrating significant survival improvements, marking a crucial advancement in addressing treatment-resistant cancers.
- Efficacy Validation: The study showed that TTX-MC138 effectively delivered to human glioblastoma in murine models, inducing a five-fold increase in apoptotic activity, further validating its potential to overcome drug delivery barriers.
- Clinical Trial Progress: TTX-MC138 has completed IND studies and toxicity testing, showing good safety in Phase I trials for non-CNS cancers, with a Phase II trial anticipated to begin in the first half of 2026, advancing its clinical application.
- Strategic Implications: This research not only provides robust biological support for TransCode's RNA therapeutic platform but also showcases its broad potential in treating metastatic tumors, potentially transforming the treatment landscape for glioblastoma.
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TransCode's TTX-MC138 Significantly Extends Survival in Glioblastoma Mouse Models
- Survival Extension: TTX-MC138 successfully delivered via intravenous injection in glioblastoma mouse models significantly extends survival, indicating its potential in treating this highly aggressive cancer.
- Target Mechanism Validation: The study demonstrates that TTX-MC138 effectively suppresses miR-10b, resulting in a five-fold increase in apoptotic activity in tumors, thereby enhancing therapeutic efficacy and supporting its clinical development.
- Preclinical Research Findings: Conducted in collaboration with Michigan State University and published in the Journal of Functional Biomaterials, this study lays the groundwork for the clinical application of TTX-MC138, which is expected to drive future clinical trials.
- Future Clinical Trial Plans: Currently undergoing Phase 1 clinical trials, TTX-MC138 is anticipated to enter Phase 2 trials in the first half of 2026, further validating its potential application in metastatic diseases.
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