Shopify and Eli Lilly Establish New Buy Points as Market Approaches Highs
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 31 2025
0mins
Should l Buy LLY?
Source: Yahoo Finance
- Market Highs: On the final day of 2025, the stock market approaches historical highs, reflecting strong market confidence and investor activity, which may attract more capital inflows.
- New Buy Points: Shopify and Eli Lilly have established new buy signals, indicating that both companies are demonstrating strong growth potential in the current market environment, likely drawing investor interest.
- Investor Sentiment: With the market nearing highs, investor sentiment is optimistic, potentially driving more capital into the technology and pharmaceutical sectors, further enhancing valuations in these areas.
- Technical Analysis Signals: The formation of new buy points may attract the attention of technical analysts, prompting increased trading activity that could influence short-term stock price fluctuations.
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Analyst Views on LLY
Wall Street analysts forecast LLY stock price to rise
20 Analyst Rating
18 Buy
2 Hold
0 Sell
Strong Buy
Current: 1036.050
Low
950.00
Averages
1192
High
1500
Current: 1036.050
Low
950.00
Averages
1192
High
1500
About LLY
Eli Lilly and Company is a medicine company, which discovers, develops, manufactures, markets, and sells pharmaceutical products worldwide. Its cardiometabolic health products include Basaglar; Humalog, Humalog Mix 75/25, Humalog U-100, Humalog U-200, Humalog Mix 50/50, insulin lispro, and others; Humulin, Humulin 70/30, and others; Jardiance; Mounjaro; Trulicity; Zepbound; VERVE-102; VERVE-201, and VERVE-301. Its oncology products include Cyramza, Erbitux, Tyvyt, and Verzenio. Its immunology products include Ebglyss, Olumiant, Omvoh, and Taltz. Its neuroscience products include Emgality and Kisunla. The Company is also engaged in radiopharmaceutical discovery, development, and manufacturing efforts, and clinical and pre-clinical radioligand therapies in development for the treatment of cancer. It is also developing an oral small molecule inhibitor of a4b7 integrin for inflammatory bowel disease (IBD). It is evaluating its novel gene therapy candidate, ixoberogene soroparvovec.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Eli Lilly's Combination Therapy Shows Significant Improvement in Psoriasis and Obesity
- Clinical Trial Results: Eli Lilly's TOGETHER-PsO Phase 3b trial revealed that 27.1% of participants receiving the combination of Taltz and Zepbound achieved complete skin clearance and at least 10% weight loss, significantly outperforming the 5.8% in the Taltz monotherapy group, indicating the efficacy of the combination therapy.
- Side Effects Analysis: Common adverse events in the Taltz and Zepbound group included nausea, diarrhea, and injection site reactions, yet the overall efficacy remains superior to monotherapy, highlighting the potential benefits of combination treatment despite the side effects.
- Partnership with CSL: Eli Lilly has entered into an agreement with Australian company CSL, which will receive an upfront payment of $100 million and potential milestone payments, as well as royalties on global net sales, facilitating the development of clazakizumab for cardiovascular event prevention.
- Market Performance Analysis: Although Eli Lilly's stock is currently trading below its 20-day and 50-day simple moving averages, indicating short-term weakness, it remains above its 100-day and 200-day moving averages, suggesting a positive long-term trend, with analysts maintaining an optimistic outlook on its future performance.
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Eli Lilly's Late-Stage Trial Achieves Key Goals
- Trial Success: Eli Lilly announced that its TOGETHER-PsO open-label Phase 3b trial successfully met both primary and key secondary endpoints, demonstrating the efficacy of its weight loss therapy Zepbound combined with psoriasis therapy Taltz, marking a significant advancement for obese or overweight patients with plaque psoriasis.
- Significant Weight Loss: Over 36 weeks, 27% of patients receiving the combination therapy achieved at least a 10% weight loss and complete skin clearance, showcasing the potential of this combination therapy to improve patient quality of life, far exceeding the 5.8% achieved with Taltz alone.
- Efficacy Comparison: The key secondary endpoint revealed that patients on the combination regimen were 40% more likely to achieve PASI 100 compared to those receiving Taltz alone, further validating the advantages of using Zepbound with Taltz, which could enhance future market acceptance.
- Safety Profile: The trial reported mostly mild to moderate adverse events consistent with the known tolerability profiles of each drug, indicating the acceptability of this combination therapy in terms of safety, laying the groundwork for future regulatory discussions.
See More
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- Clinical Trial Results: In the TOGETHER-PsO study, the combination of Taltz and Zepbound achieved complete skin clearance (PASI 100) and ≥10% weight loss in 27.1% of patients at 36 weeks, significantly higher than the 5.8% in the Taltz monotherapy group (p<0.001), indicating the importance of combination therapy in improving patient quality of life.
- Significant Relative Advantage: Patients in the combination therapy group were 40% more likely to achieve PASI 100 compared to those on monotherapy, with rates of 40.6% versus 29.0% (p<0.05), demonstrating the positive impact of obesity treatment on psoriasis and providing new directions for future treatment strategies.
- High BMI Patient Population: The average BMI of study participants exceeded 39 kg/m², highlighting the high disease burden in this group and emphasizing the need for comprehensive treatment approaches for obesity and psoriasis, which could change clinical practice standards.
- Good Safety Profile: Adverse events in the combination therapy were generally mild to moderate, primarily including nausea, diarrhea, and injection site reactions, consistent with known safety profiles, indicating the feasibility and safety of this treatment regimen in clinical applications.
See More
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- Increased Disease Awareness: As awareness of juvenile idiopathic arthritis rises, the total cases in the 7MM are expected to increase from 141,800 in 2025 to 173,000 by 2036, with a CAGR of 1.8%, driving demand for new treatment options.
- Emerging Therapies Launch: Emerging therapies such as SOTYKTU from Bristol-Myers Squibb and BIMZELX from UCB Biopharma are in clinical trials and are expected to transform the market landscape by providing more effective treatment options, thereby enhancing patient quality of life.
- Intensifying Market Competition: With multiple pharmaceutical companies like Novartis and AbbVie entering the juvenile idiopathic arthritis treatment space, competition will intensify, driving innovation and R&D investment, further accelerating rapid market development.
See More
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- License Transaction Value: Eli Lilly will pay Australian biopharma CSL $100 million for a license to explore additional indications for the anti-IL-6 monoclonal antibody clazakizumab, reflecting Lilly's recognition of the drug's potential market.
- Clinical Development Stage: Clazakizumab is currently in phase 3 development aimed at preventing cardiovascular events in individuals with end-stage kidney disease, with CSL retaining rights for this indication, indicating its ongoing investment and commitment in this area.
- Milestone Payments and Royalties: The agreement allows CSL to be eligible for milestone payments and royalties on global net sales for clazakizumab indications that Lilly gains approval for, providing CSL with a continuous revenue stream and enhancing its financial stability.
- Immuno-inflammatory Treatment Potential: CSL noted that by inhibiting IL-6 from binding with its receptor, clazakizumab could treat immuno-inflammatory conditions, which may open new opportunities for the company's future product line expansion.
See More
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- Impact of Weight-Loss Drugs: Analysts suggest that the rising popularity of GLP-1 weight-loss drugs could lead to lighter passengers and significant fuel savings for airlines, although this overly optimistic view may inflate investor expectations for airline stocks.
- Food Stocks Market Reaction: Despite significant declines in food stocks due to fears surrounding GLP-1, analysts note that while dividends may be attractive, the lack of growth potential limits rebound opportunities, as seen with Conagra Brands.
- AI Market Influence: Comments from Anthropic CEO Dario Amodei have sparked widespread discussions about the future of AI, although the justification for the company's $350 billion valuation is questioned, and the impact on companies like Adobe, Workday, and Salesforce may lead to declining valuations.
- Challenges in Data Center Construction: Analysts emphasize that the cost of building data centers must decrease and power supply must be reliable to achieve profitability in the coming years, although they remain optimistic about the long-term prospects for companies like Amazon, Microsoft, and Alphabet.
See More
Eli Lilly's Combination Therapy Shows Significant Improvement in Psoriasis and Obesity
- Clinical Trial Results: Eli Lilly's TOGETHER-PsO Phase 3b trial revealed that 27.1% of participants receiving the combination of Taltz and Zepbound achieved complete skin clearance and at least 10% weight loss, significantly outperforming the 5.8% in the Taltz monotherapy group, indicating the efficacy of the combination therapy.
- Side Effects Analysis: Common adverse events in the Taltz and Zepbound group included nausea, diarrhea, and injection site reactions, yet the overall efficacy remains superior to monotherapy, highlighting the potential benefits of combination treatment despite the side effects.
- Partnership with CSL: Eli Lilly has entered into an agreement with Australian company CSL, which will receive an upfront payment of $100 million and potential milestone payments, as well as royalties on global net sales, facilitating the development of clazakizumab for cardiovascular event prevention.
- Market Performance Analysis: Although Eli Lilly's stock is currently trading below its 20-day and 50-day simple moving averages, indicating short-term weakness, it remains above its 100-day and 200-day moving averages, suggesting a positive long-term trend, with analysts maintaining an optimistic outlook on its future performance.
See More
Eli Lilly's Late-Stage Trial Achieves Key Goals
- Trial Success: Eli Lilly announced that its TOGETHER-PsO open-label Phase 3b trial successfully met both primary and key secondary endpoints, demonstrating the efficacy of its weight loss therapy Zepbound combined with psoriasis therapy Taltz, marking a significant advancement for obese or overweight patients with plaque psoriasis.
- Significant Weight Loss: Over 36 weeks, 27% of patients receiving the combination therapy achieved at least a 10% weight loss and complete skin clearance, showcasing the potential of this combination therapy to improve patient quality of life, far exceeding the 5.8% achieved with Taltz alone.
- Efficacy Comparison: The key secondary endpoint revealed that patients on the combination regimen were 40% more likely to achieve PASI 100 compared to those receiving Taltz alone, further validating the advantages of using Zepbound with Taltz, which could enhance future market acceptance.
- Safety Profile: The trial reported mostly mild to moderate adverse events consistent with the known tolerability profiles of each drug, indicating the acceptability of this combination therapy in terms of safety, laying the groundwork for future regulatory discussions.
See More
Taltz and Zepbound Combination Therapy Significantly Outperforms Monotherapy
- Clinical Trial Results: In the TOGETHER-PsO study, the combination of Taltz and Zepbound achieved complete skin clearance (PASI 100) and ≥10% weight loss in 27.1% of patients at 36 weeks, significantly higher than the 5.8% in the Taltz monotherapy group (p<0.001), indicating the importance of combination therapy in improving patient quality of life.
- Significant Relative Advantage: Patients in the combination therapy group were 40% more likely to achieve PASI 100 compared to those on monotherapy, with rates of 40.6% versus 29.0% (p<0.05), demonstrating the positive impact of obesity treatment on psoriasis and providing new directions for future treatment strategies.
- High BMI Patient Population: The average BMI of study participants exceeded 39 kg/m², highlighting the high disease burden in this group and emphasizing the need for comprehensive treatment approaches for obesity and psoriasis, which could change clinical practice standards.
- Good Safety Profile: Adverse events in the combination therapy were generally mild to moderate, primarily including nausea, diarrhea, and injection site reactions, consistent with known safety profiles, indicating the feasibility and safety of this treatment regimen in clinical applications.
See More
Analysis of Growth in Juvenile Idiopathic Arthritis Market
- Market Size Growth: According to DelveInsight's analysis, the juvenile idiopathic arthritis market is projected to reach USD 2.3 billion by 2025, indicating stable growth potential over the next decade, reflecting increasing demand for new therapies.
- Increased Disease Awareness: As awareness of juvenile idiopathic arthritis rises, the total cases in the 7MM are expected to increase from 141,800 in 2025 to 173,000 by 2036, with a CAGR of 1.8%, driving demand for new treatment options.
- Emerging Therapies Launch: Emerging therapies such as SOTYKTU from Bristol-Myers Squibb and BIMZELX from UCB Biopharma are in clinical trials and are expected to transform the market landscape by providing more effective treatment options, thereby enhancing patient quality of life.
- Intensifying Market Competition: With multiple pharmaceutical companies like Novartis and AbbVie entering the juvenile idiopathic arthritis treatment space, competition will intensify, driving innovation and R&D investment, further accelerating rapid market development.
See More
Eli Lilly Pays $100M for Clazakizumab License from CSL
- License Transaction Value: Eli Lilly will pay Australian biopharma CSL $100 million for a license to explore additional indications for the anti-IL-6 monoclonal antibody clazakizumab, reflecting Lilly's recognition of the drug's potential market.
- Clinical Development Stage: Clazakizumab is currently in phase 3 development aimed at preventing cardiovascular events in individuals with end-stage kidney disease, with CSL retaining rights for this indication, indicating its ongoing investment and commitment in this area.
- Milestone Payments and Royalties: The agreement allows CSL to be eligible for milestone payments and royalties on global net sales for clazakizumab indications that Lilly gains approval for, providing CSL with a continuous revenue stream and enhancing its financial stability.
- Immuno-inflammatory Treatment Potential: CSL noted that by inhibiting IL-6 from binding with its receptor, clazakizumab could treat immuno-inflammatory conditions, which may open new opportunities for the company's future product line expansion.
See More
Impact of Weight-Loss Drugs on Airline Stocks
- Impact of Weight-Loss Drugs: Analysts suggest that the rising popularity of GLP-1 weight-loss drugs could lead to lighter passengers and significant fuel savings for airlines, although this overly optimistic view may inflate investor expectations for airline stocks.
- Food Stocks Market Reaction: Despite significant declines in food stocks due to fears surrounding GLP-1, analysts note that while dividends may be attractive, the lack of growth potential limits rebound opportunities, as seen with Conagra Brands.
- AI Market Influence: Comments from Anthropic CEO Dario Amodei have sparked widespread discussions about the future of AI, although the justification for the company's $350 billion valuation is questioned, and the impact on companies like Adobe, Workday, and Salesforce may lead to declining valuations.
- Challenges in Data Center Construction: Analysts emphasize that the cost of building data centers must decrease and power supply must be reliable to achieve profitability in the coming years, although they remain optimistic about the long-term prospects for companies like Amazon, Microsoft, and Alphabet.
See More
