Prime Medicine Publishes Phase 1/2 Data for PM359, Demonstrating Significant Efficacy
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 07 2025
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Source: Newsfilter
- Clinical Data Release: Prime Medicine published Phase 1/2 clinical data for PM359 in the New England Journal of Medicine, demonstrating that two patients achieved 69% and 83% neutrophil engraftment by Day 30, significantly exceeding the 20% minimum threshold for clinical benefit, marking the first human validation of Prime Editing's safety and efficacy.
- Sustained Efficacy: Both patients remained free of new CGD-related complications post-treatment, with Patient 1 stopping mesalamine without CAC flare-ups and Patient 2 showing a substantial decrease in fecal calprotectin levels, indicating PM359's potential to enhance patient quality of life.
- Safety Assessment: No clinically significant adverse events attributable to PM359 were observed during treatment, with all noted toxicities consistent with busulfan-based conditioning, further supporting the safety profile of Prime Editing technology.
- Future Development Potential: This data release not only showcases PM359's early clinical efficacy but also provides critical insights into the broad applicability of Prime Editing technology in gene editing, potentially opening new avenues for treating various genetic and immunological diseases.
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Analyst Views on PRME
Wall Street analysts forecast PRME stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for PRME is 6.06 USD with a low forecast of 4.25 USD and a high forecast of 9.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
7 Analyst Rating
4 Buy
3 Hold
0 Sell
Moderate Buy
Current: 4.030
Low
4.25
Averages
6.06
High
9.00
Current: 4.030
Low
4.25
Averages
6.06
High
9.00
About PRME
Prime Medicine, Inc. is a biotechnology company engaged in creating and delivering gene editing therapies to patients. It deploys its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated one-time curative genetic therapies. It is advancing a set of high-value programs across its core areas of focus (hematology, immunology and oncology, liver, and lung). These include ex vivo hematopoietic stem cell (HSC) programs for the treatment of p47phox chronic granulomatous disease CGD and X-linked CGD; a lipid nanoparticle (LNP) Prime Editor for the treatment of Wilson’s Disease; a LNP or adeno-associated virus Prime Editors for the treatment of cystic fibrosis; and ex vivo T-cell therapies. PM359, its product candidate within its hematology, immunology and oncology area of focus, targets the p47phox variant of CGD. Its PM577 comprises a Prime Editor encapsulated as RNA cargo in a liver-targeted LNP.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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