POWER1 Study Results Fail to Meet Primary Success Measure
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jun 01 2026
0mins
Source: Newsfilter
- Study Results Analysis: The POWER1 study did not meet its primary success measure; however, a 50% response rate was achieved in the higher dose (30mg) group, indicating a more pronounced reduction in seizures during the latter half of the study, despite overall results falling short of expectations.
- Safety Assessment: Vormatrigine was generally well-tolerated, with adverse event-related discontinuations below 10%, suggesting a high safety profile that may enhance patient adherence to treatment.
- Patient Transition Status: Approximately 90% of patients from the vormatrigine arm transitioned to the open-label extension (OLE) study, indicating sustained interest and potential long-term efficacy of the drug among participants.
- Study Adjustment Plans: Praxis is pausing enrollment in the POWER2 study to reassess the vormatrigine program and consider potential modifications, reflecting the company's cautious approach to research direction and aiming to optimize future clinical development strategies.
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Analyst Views on PRAX
Wall Street analysts forecast PRAX stock price to rise
15 Analyst Rating
14 Buy
0 Hold
1 Sell
Strong Buy
Current: 270.010
Low
95.00
Averages
456.71
High
843.00
Current: 270.010
Low
95.00
Averages
456.71
High
843.00
About PRAX
Praxis Precision Medicines, Inc. is an integrated, central nervous system (CNS) precision neuroscience biopharmaceutical company, translating insights from genetic epilepsies into the development of therapies for CNS disorders characterized by neuronal excitation-inhibition imbalance. The Company is applying genetic insights to the discovery and development of therapies for neurological disorders through two platforms. Its platform includes Cerebrum, a small-molecule platform, which utilizes deep understanding of neuronal excitability and neuronal networks and applies a series of computational and experimental tools to develop orally available precision therapies, and Solidus, an antisense oligonucleotide platform, is a targeted precision medicine discovery and development engine anchored on a proprietary, computational methodology. The Company's product candidates include Ulixacaltamide, Vormatrigine, Relutrigine, PRAX-080, Elsunersen, and others.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Long-term Revenue Prospects: Timashev also mentioned that Praxis could achieve over $7.8 billion in revenue by 2035, which is attractive to investors and suggests strong growth potential in future market competition.
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See More
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- Need for Dose Adjustment: Although a more pronounced seizure reduction was observed at the 30mg dose, it still did not meet the prespecified endpoint, leading Praxis to pause enrollment in the POWER2 study to reassess potential modifications, indicating a cautious approach to future research directions.
- Positive Outlook for IDEAYA: Wedbush reaffirmed its Outperform rating on IDEAYA Biosciences with a price target of $58, based on positive results from the OptimUM-02 study, which demonstrated significant improvement in progression-free survival with Darovasertib plus Crizotinib compared to the control group.
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See More
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See More
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