OmniAb Raises 2026 Revenue Guidance to $28M-$33M
OmniAb revises 2026 financial guidance and now expects revenue to be in the range of $28 million to $33 million, versus $25 million to $30 million previously, and costs and operating expenses to be in the range of $83 million to $88 million, versus $80 million to $85 million previously. Cash costs and operating expenses remain unchanged and are expected to be in the range of $50 million to $55 million (see note regarding "Use of Non-GAAP Financial Measure" below for further discussion of this non-GAAP measure). The Company now expects to end the year with cash and cash equivalents in the range of $33 million to $38 million, versus $30 million to $35 million previously. The full-year 2026 effective tax rate is expected to be approximately 0%.
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- Significant Revenue Growth: OmniAb reported total revenue of $14.4 million for Q1 2026, exceeding expectations by $8.8 million, reflecting strong progress in partner programs that is expected to drive future milestones and new royalty income.
- Expanded Partner Base: As of the end of Q1, OmniAb had 107 active partners and 409 active programs, with total contracted milestones exceeding $3 billion and an average royalty rate of approximately 3.4%, laying a solid foundation for future revenue diversification.
- Upgraded Financial Outlook: The company raised its total revenue guidance for 2026 to a range of $28 million to $33 million, primarily driven by a milestone achieved by a partner that was not included in the original guidance, while maintaining cash operating expense expectations unchanged at $50 million to $55 million.
- Ongoing Clinical Progress: By the end of Q1, OmniAb had 32 active clinical programs, with Ramantamig advancing from Phase I to Phase III, demonstrating strong development potential in the clinical stage and further enhancing market competitiveness.
- Partner Growth: By the end of 2025, OmniAb had 107 partners and 407 active programs, reflecting a net increase of 44 programs compared to 2024, demonstrating the company's ongoing expansion in its partner base and program portfolio, despite a decline in overall revenue, laying a foundation for sustained future growth.
- Innovation Platform Launch: OmniUltra, the industry's first transgenic chicken platform, was launched in December 2025, aimed at driving new partner additions and program starts, expected to generate near-term revenue opportunities and extend into peptide discovery applications.
- Financial Performance: Total revenue for 2025 was $18.4 million, down from $26.4 million in 2024, primarily due to a decrease in license revenue, although milestone revenue increased, indicating the company's efforts in cost control and operational optimization.
- Future Outlook: The company expects revenue in 2026 to range from $25 million to $30 million, with operating expenses controlled between $80 million and $85 million, indicating a trajectory towards positive cash flow while continuing to invest in technological innovation and market expansion.
- Partner Growth: By the end of 2025, OmniAb increased its partner count from 104 to 107 and active programs from 399 to 407, demonstrating strong momentum in expanding partnerships and projects, which is expected to support future revenue growth.
- OmniUltra Launch: The introduction of OmniUltra at the Antibody Engineering Conference, touted as the industry's first transgenic chicken platform for ultra-long CDRH3 on a human antibody framework, is anticipated to attract new partners and enhance near-term revenue opportunities, further solidifying the company's market position.
- Financial Performance: Q4 2025 total revenue was reported at $8.4 million, down from $10.8 million in the same period in 2024, primarily due to decreased license revenue, although milestone revenue increased, reflecting the company's efforts in revenue diversification.
- 2026 Outlook: The CFO projected 2026 revenue to range between $25 million and $30 million, with operating expenses expected to be between $80 million and $85 million, indicating a positive outlook for future growth while maintaining operational efficiency.
- Earnings Miss: OmniAb's Q4 GAAP EPS of -$0.11 falls short by $0.02, indicating challenges in profitability that could negatively impact investor confidence.
- Revenue Decline: The company reported revenue of $8.4 million, a 22.2% year-over-year decrease, missing expectations by $0.6 million, reflecting weak market demand and increased competition that may affect future market share.
- Future Outlook: OmniAb expects 2026 revenue to range between $25 million and $30 million, with operating costs projected at $80 million to $85 million, highlighting pressure on cost control that could impact profitability.
- Cash Flow Status: The company anticipates ending the year with cash and cash equivalents between $30 million and $35 million, indicating stable cash flow; however, high operating costs may limit investment capacity and growth potential.

- Platform Innovation: OmniAb launched the OmniUltra™ platform at the Antibody Engineering & Therapeutics Conference in San Diego, marking the industry's first transgenic chicken platform capable of expressing ultralong CDRH3 domains, significantly broadening therapeutic applications.
- Technical Advantages: The platform generates antibodies and picobodies™ with high specificity and structural stability, accelerating the drug discovery process, particularly showcasing immense potential in bispecific and multispecific drug development.
- Market Prospects: The launch of the OmniUltra platform is expected to attract strong interest from industry partners, further solidifying OmniAb's leadership in next-generation drug discovery and facilitating entry into new markets.
- Industry Engagement: OmniAb is conducting two presentations at the conference, highlighting the broad applicability of its technology and emphasizing the platform's significance in the discovery of novel mini-proteins and structured peptides, enhancing interaction with potential customers.








