Kura Oncology and Kyowa Kirin Update KOMET-007 Trial Results
Written by Emily J. Thompson, Senior Investment Analyst
Updated: May 12 2026
0mins
Should l Buy KURA?
Kura Oncology, (KURA) and Kyowa Kirin (KYKOF) announced that updated results from the frontline arm of the Phase 1 KOMET-007 clinical trial evaluating ziftomenib in combination with cytarabine plus daunorubicin in patients with newly diagnosed NPM1-mutant or KMT2A-rearranged acute myeloid leukemia have been accepted for an oral presentation on Sunday, June 14, 2026, at the upcoming 2026 European Hematology Association Congress in Stockholm, Sweden. The oral presentation will highlight updated results in 99 patients with newly diagnosed NPM1-m or KMT2A-r AML treated with ziftomenib 600 mg once daily in combination with 7+3. These results represent one of the largest datasets reported to date for the evaluation of a menin inhibitor in combination with intensive chemotherapy in frontline AML. As of the abstract data cut-off on January 16, 2026: High response rates across both molecular subtypes; Composite complete response rates of 96% for NPM1-m and 90% for KMT2A-r AML; Deep molecular responses; Measurable residual disease-negativity rates among CRc responders of 83% for NPM1-m and 82% for KMT2A-r AML; Encouraging durability with extended follow-up; Median follow-up of 14.9 months and 9.3 months; Median duration of CRc not reached and 11.2 months; Consistent and manageable safety profile; Safety profile consistent across the NPM1-m and KMT2A-r groups with no new safety signals observed with long-term treatment; Updated analyses with longer median follow-up, central MRD assessment, durability outcomes, and deeper characterization of safety and hematologic recovery will be included at the time of the oral presentation. "With nearly 100 patients treated as well as extended follow-up, ziftomenib in combination with 7+3 continues to demonstrate consistently high response rates, deep MRD negativity, and encouraging durability across genetically defined AML subsets," said Mollie Leoni, CMO. "These data support our belief ziftomenib has potential to serve as a foundational backbone for frontline AML therapy, and we are advancing this regimen in our ongoing Phase 3 registrational program."
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Analyst Views on KURA
Wall Street analysts forecast KURA stock price to rise
10 Analyst Rating
9 Buy
1 Hold
0 Sell
Strong Buy
Current: 9.200
Low
16.00
Averages
29.71
High
40.00
Current: 9.200
Low
16.00
Averages
29.71
High
40.00
About KURA
Kura Oncology, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on precision medicine for the treatment of cancer. Its pipeline consists of small molecule product candidates that target cancer signaling pathways. Its product candidates include KOMZIFTI (Ziftomenib), Tipifarnib, and Darlifarnib (KO-2806). Ziftomenib, is a potent, selective, reversible and oral small molecule inhibitor that blocks the interaction of two proteins, menin and the protein expressed by the Lysine K-specific Methyl Transferase 2A gene, or KMT2A gene. Ziftomenib is a selective investigational inhibitor of the menin-KMT2A protein-protein interaction for the treatment of genetically defined subsets of acute leukemias. Tipifarnib is a potent, selective and orally bioavailable farnesyl transferase inhibitor (FTI). The KO-2806 is an FTI, is being evaluated in a Phase I first-in-human trial as a monotherapy and in combination with other targeted therapies.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Kura Oncology Reports Strong Q1 2026 Earnings with $5.8M Revenue
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- Significant Coverage Improvement: The company secured coverage for over 93% of insured lives at parity or better without label restrictions, greatly enhancing its competitive position and facilitating sales growth.
- Increased R&D Spending: R&D expenses reached $65.3 million, with selling and administrative expenses at $31.6 million in Q1, yet the company maintains its guidance for collaboration revenue of $45 million to $55 million in 2026, reflecting confidence in future growth.
- Optimistic Future Outlook: Kura expects collaboration revenue to reach $90 million to $110 million from 2026 to 2028, with cash and short-term investments totaling $580.8 million, sufficient to support its AML program through anticipated top-line results from KOMET-017 in 2028.
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- R&D Expenses Increase: Research and development expenses rose to $65.3 million in Q1 2026, up from $56 million in Q1 2025, primarily driven by ziftomenib combination trials, reflecting the company's ongoing commitment to innovative drug development.
- Widening Net Loss: Kura's net loss for Q1 2026 was $73.3 million, significantly higher than the $57.4 million loss in Q1 2025, indicating increased financial pressure during commercialization that could impact future financing capabilities.
- Cash Reserves Decline: As of March 31, 2026, the company's cash and short-term investments decreased to $580.8 million from $667.2 million at the end of 2025, highlighting financial strain from operational and R&D expenditures that may limit future expansion plans.
See More
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- Revenue Decline: The company generated $18.26 million in revenue for Q1, falling short of the $24.92 million forecast, primarily due to collaboration revenue dropping to $12.5 million from $14.1 million year-over-year, reflecting weak market demand.
- Increased R&D Expenses: R&D expenses rose to $65.3 million compared to $56.0 million last year, driven by advancements in ziftomenib combination trials, which may offer potential breakthroughs in the long term but add financial strain in the short term.
- Cash Flow Status: As of March 31, 2026, Kura had $580.8 million in cash and short-term investments, down from $667.2 million at the end of 2025; while the anticipated $180 million from the collaboration with Kyowa Kirin is expected to support future clinical trials, careful cash management is essential.
See More
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- Durability of Efficacy: With a median follow-up of approximately 15 months for NPM1-mutant patients, the median duration of complete response has not yet been reached, indicating the potential for long-term efficacy that could redefine treatment standards for AML.
- FDA Accelerated Review Prospects: The ongoing Phase 3 KOMET-017 trial is currently enrolling patients, with the potential for accelerated FDA review in 2028, which could positively impact Kura Oncology's market outlook and expedite the introduction of new therapies.
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See More
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- Earnings Estimate Fluctuations: Over the past three months, EPS estimates have seen one upward revision and three downward adjustments, while revenue estimates experienced five upward revisions and four downward changes, reflecting market uncertainty regarding the company's future performance.
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See More
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- Stock Option Grant: On May 1, 2026, Kura Oncology granted 133,750 nonstatutory stock options to five new employees, aimed at attracting and retaining talent, thereby enhancing the company's competitive position in the biopharmaceutical sector.
- Exercise Price Setting: Each stock option has an exercise price of $8.77 per share, equal to the closing price on the grant date, a strategy that aligns employee interests with those of shareholders.
- Vesting Arrangement: The stock options will vest over four years, with 25% vesting on the one-year anniversary and the remainder vesting monthly, ensuring continued contributions from new employees during their tenure with the company.
- Incentive Plan Context: This grant is made in accordance with Nasdaq Listing Rule 5635(c)(4), reflecting the company's commitment to talent and its long-term development in the precision medicine field.
See More
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- Revenue Exceeds Expectations: Kura Oncology generated $5.8 million in net product revenue in Q1 2026, surpassing expectations, with 85 new patient starts indicating growing acceptance of KOMZIFTI in the market.
- Significant Coverage Improvement: The company secured coverage for over 93% of insured lives at parity or better without label restrictions, greatly enhancing its competitive position and facilitating sales growth.
- Increased R&D Spending: R&D expenses reached $65.3 million, with selling and administrative expenses at $31.6 million in Q1, yet the company maintains its guidance for collaboration revenue of $45 million to $55 million in 2026, reflecting confidence in future growth.
- Optimistic Future Outlook: Kura expects collaboration revenue to reach $90 million to $110 million from 2026 to 2028, with cash and short-term investments totaling $580.8 million, sufficient to support its AML program through anticipated top-line results from KOMET-017 in 2028.
See More
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- Product Revenue Growth: Kura Oncology reported $5.8 million in product revenue from KOMZIFTI in Q1 2026, exceeding expectations and indicating strong physician adoption and repeat prescriptions, thereby enhancing the company's market position across treatment centers.
- R&D Expenses Increase: Research and development expenses rose to $65.3 million in Q1 2026, up from $56 million in Q1 2025, primarily driven by ziftomenib combination trials, reflecting the company's ongoing commitment to innovative drug development.
- Widening Net Loss: Kura's net loss for Q1 2026 was $73.3 million, significantly higher than the $57.4 million loss in Q1 2025, indicating increased financial pressure during commercialization that could impact future financing capabilities.
- Cash Reserves Decline: As of March 31, 2026, the company's cash and short-term investments decreased to $580.8 million from $667.2 million at the end of 2025, highlighting financial strain from operational and R&D expenditures that may limit future expansion plans.
See More
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- Disappointing Earnings: Kura Oncology reported a Q1 GAAP EPS of -$0.83, missing expectations by $0.01, indicating ongoing challenges in profitability that may affect investor confidence.
- Revenue Decline: The company generated $18.26 million in revenue for Q1, falling short of the $24.92 million forecast, primarily due to collaboration revenue dropping to $12.5 million from $14.1 million year-over-year, reflecting weak market demand.
- Increased R&D Expenses: R&D expenses rose to $65.3 million compared to $56.0 million last year, driven by advancements in ziftomenib combination trials, which may offer potential breakthroughs in the long term but add financial strain in the short term.
- Cash Flow Status: As of March 31, 2026, Kura had $580.8 million in cash and short-term investments, down from $667.2 million at the end of 2025; while the anticipated $180 million from the collaboration with Kyowa Kirin is expected to support future clinical trials, careful cash management is essential.
See More
Kura Oncology Presents AML Clinical Trial Data with Promising Results
- Clinical Trial Highlights: Kura Oncology will present data from 99 patients with newly diagnosed NPM1-mutant or KMT2A-rearranged acute myeloid leukemia (AML) at the 2026 European Hematology Association Congress, showcasing a complete response rate of up to 96% and over 80% deep molecular negativity, providing new hope for AML treatment.
- Durability of Efficacy: With a median follow-up of approximately 15 months for NPM1-mutant patients, the median duration of complete response has not yet been reached, indicating the potential for long-term efficacy that could redefine treatment standards for AML.
- FDA Accelerated Review Prospects: The ongoing Phase 3 KOMET-017 trial is currently enrolling patients, with the potential for accelerated FDA review in 2028, which could positively impact Kura Oncology's market outlook and expedite the introduction of new therapies.
- Virtual Investor Call: Kura will host a virtual investor call on June 3 to discuss the latest developments from the KOMET-007 study, further enhancing investor confidence in the company's future growth.
See More
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- Earnings Announcement: Kura Oncology is set to release its Q1 earnings on May 12 after market close, with consensus EPS estimates at -$0.78 and revenue expectations at $25.92 million, indicating financial pressure on the company.
- Earnings Estimate Fluctuations: Over the past three months, EPS estimates have seen one upward revision and three downward adjustments, while revenue estimates experienced five upward revisions and four downward changes, reflecting market uncertainty regarding the company's future performance.
- Cancer Treatment Developments: Kura Oncology discussed updated data on the combination of Darlifarnib and Cabozantinib in advanced renal cell carcinoma, showcasing the company's ongoing R&D efforts in cancer treatment, which may pave the way for future market opportunities.
- Market Opportunity Outlook: Kura Oncology anticipates a $7 billion market opportunity with the launch of KOMZIFTI in acute myeloid leukemia (AML), and advancing combination strategies could significantly enhance the company's growth potential.
See More
Kura Oncology Grants Stock Options to New Employees
- Stock Option Grant: On May 1, 2026, Kura Oncology granted 133,750 nonstatutory stock options to five new employees, aimed at attracting and retaining talent, thereby enhancing the company's competitive position in the biopharmaceutical sector.
- Exercise Price Setting: Each stock option has an exercise price of $8.77 per share, equal to the closing price on the grant date, a strategy that aligns employee interests with those of shareholders.
- Vesting Arrangement: The stock options will vest over four years, with 25% vesting on the one-year anniversary and the remainder vesting monthly, ensuring continued contributions from new employees during their tenure with the company.
- Incentive Plan Context: This grant is made in accordance with Nasdaq Listing Rule 5635(c)(4), reflecting the company's commitment to talent and its long-term development in the precision medicine field.
See More
