Innovent Biologics Announces Preliminary Results of IBI363 Clinical Study
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jun 01 2026
0mins
Innovent Biologics announced the preliminary results from a PoC clinical study of its global first-in-class PD-1/IL-2alpha-bias bispecific fusion protein IBI363 plus chemotherapy in the first-line treatment of advanced non-small cell lung cancer, NSCLC. The detailed data was presented today at the 2026 American Society of Clinical Oncology, ASCO, Annual Meeting. Key highlights: IBI363 in combination with chemotherapy demonstrated encouraging efficacy signals and manageable safety in the first-line treatment of NSCLC with PD-L1 negative or low expression. The 3 to 1.5 mg/kg dose group showed ORR of 86.4%, confirmed ORR of 81.8% and DCR of 100%; The second stage of the PoC study is ongoing in head-to-head comparison vs. pembrolizumab plus chemotherapy in the first-line treatment of advanced NSCLC; Innovent and Takeda (TAK) are co-developing IBI363 globally.
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Current: 15.420
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About TAK
Takeda Pharmaceutical Co Ltd is a Japan-based company mainly engaged in the research, development, manufacturing and global sales of a wide range of pharmaceuticals. Its main business areas are divided into six, including gastroenterology, rare diseases, plasma-derived therapies, oncology (cancer), vaccines, and neuroscience (neuropsychiatric disorders). In research and development, the Company focuses on three priority disease areas, including gastroenterology and inflammatory diseases, neuroscience, and oncology, and also focuses on plasma-derived therapies.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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See More
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See More
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- Cognitive Function Enhancement: Oveporexton demonstrated a notable improvement in cognitive symptoms associated with narcolepsy, with approximately 70% of patients across all doses reporting no significant cognitive difficulties compared to about 15% in the placebo group, highlighting the drug's potential to enhance patients' quality of life.
- Nighttime Sleep Quality Improvement: The studies revealed that Oveporexton significantly improved nighttime sleep quality, with most patients reporting no hallucinations or sleep paralysis, particularly those on the 2mg dose, who experienced meaningful reductions in disturbed nighttime sleep, thus providing a better sleep experience for patients.
- Regulatory Review Progress: The New Drug Application for Oveporexton has been accepted by the FDA for Priority Review, with a goal date in the third quarter of this year, marking a significant milestone for Takeda in the narcolepsy treatment landscape and potentially offering revolutionary treatment options for patients.
See More
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- Market Application Plans: Takeda intends to submit marketing applications for zasocitinib to the U.S. FDA and other regulatory agencies within this fiscal year, aiming to capitalize on its promising results in psoriasis treatment.
- Future Data Presentation: The company plans to present full LATITUDE trial data at an upcoming medical event, which will provide deeper insights for investors and the medical community, thereby enhancing market confidence.
See More
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